2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…2020 American Transplant Congress
CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…2019 American Transplant Congress
Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8+ T Cell Apoptosis in a Rat Liver Transplantation Model
*Purpose: In liver transplantation (LT), acute rejection (AR) remains a common complication that significantly shortens recipient survival although various immunosuppressors have been used in clinical…2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…2019 American Transplant Congress
Early T Cell Infiltration is Modulated by PD-1/PD-L1 Interactions in Kidney Graft
Inflammation and Immunity, Lerner Research Institute, Cleveland, OH
*Purpose: Allogeneic transplants elicit dynamic T cell responses that are modulated by positive and negative co-stimulatory receptors. We have investigated the impact of PD-1, a…2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…2019 American Transplant Congress
p40 Homodimer Indirectly Induce Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High-Risk Allografts via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4…2019 American Transplant Congress
Treg Suppressor Function within Allografts is Required for Tolerance
Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The role of regulatory CD4+Foxp3+ T cells (Treg) suppressor function within allografts in tolerance remains unclear. Thus, we sought to directly address: 1) whether…
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