ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell graft infiltration"

  • 2022 American Transplant Congress

    TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3+ Treg

    C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford

    Emory University Transplant Center, Emory University, Atlanta, GA

    *Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
  • 2022 American Transplant Congress

    p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts

    H. Tsuda1, A. Valujskikh2, R. Fairchild3

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2The Cleveland Clinic Fdn, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
  • 2022 American Transplant Congress

    The Impact of Early Graft Infiltrating TCF-1LowPD-1HighCD8+ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model

    T. Ota1, R. Goto1, T. Harada1, Y. Ganchiku1, M. Zaitsu1, A. Forgioni1, N. Kawamura2, M. Watanabe2, M. Fukai1, T. Shimamura3, A. Taketomi1

    1Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, 2Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan

    *Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
  • 2021 American Transplant Congress

    Utility of Follow-up Biopsies After Acute Rejection in Pediatric Kidney Transplantation

    S. S. Raza1, V. Hauptfeld-Dolejsek1, F. Rosenblum1, E. C. Mroczek-Musulman2, D. R. Kelly2, M. Seifert1

    1Department of Nephrology, UAB School of Medicine, Birmingham, AL, 2Children’s of Alabama, Birmingham, AL

    *Purpose: Treatment of acute kidney transplant rejection in children is often guided by creatinine-based estimates of GFR (eGFR) that may lack sensitivity to determine the…
  • 2021 American Transplant Congress

    Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model

    K. Bruestle1, R. Tavare2, F. Fredriksson1, E. Duggan1, F. Huang1, B. Bhola1, J. Giurleo2, R. Foster2, P. Krueger2, M. Dobosz2, D. Ekanayake-Alper1, H. Sakai1, B. Piegari1, J. Castrillion1, S. M. Coley1, O. Harari2, A. Mintz1, D. Ma2, A. Griesemer1

    1Columbia University Medical Center, New York City, NY, 2Regeneron Pharmaceuticals, Inc, New York City, NY

    *Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
  • 2021 American Transplant Congress

    Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies

    J. Torrealba, S. Moore, S. Sathirareuangchai, L. De Las Casas, Q. Cai

    Pathology, UTSW Medical Ctr, Dallas, TX

    *Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…
  • 2021 American Transplant Congress

    The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation

    A. Senev, E. Van Loon, M. Emonds, M. Naesens

    Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    *Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
  • 2021 American Transplant Congress

    P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts

    H. Tsuda, A. Valujskikh, R. Fairchild

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
  • 2021 American Transplant Congress

    Dynamic Reconstitution of Recipient Resident Memory T Cell Repertoire After Human Intestinal Transplantation

    W. Jiao, M. Martinez, J. Zuber, A. Obradovic, R. Jones, E. Waffarn, Z. Wang, A. Gorur, K. Rogers, T. Kato, Y. Shen, J. Fu, M. Sykes

    Columbia University, New York, NY

    *Purpose: Our studies in intestinal transplant (ITx) recipients demonstrated that donor T cell blood macrochimerism(peak level ≥4%) is associated with slower graft T cell replacement…
  • 2020 American Transplant Congress

    Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection

    T. Hirai1, A. Mayer2, T. W. Nobashi2, Z. Xiao2, T. Udagawa3, K. Seo4, F. Simonetta5, J. Baker5, A. Cheng3, S. S. Gambhir2, R. S. Negrin5

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Radiology, Stanford University, Stanford, CA, 3Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, 4Division of Cardiovascular Medicine, Stanford University, Stanford, CA, 5Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA

    *Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
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