Articles tagged "T cell graft infiltration"

2020 American Transplant Congress
Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection
T. Hirai¹, A. Mayer², T. W. Nobashi², Z. Xiao², T. Udagawa³, K. Seo⁴, F. Simonetta⁵, J. Baker⁵, A. Cheng³, S. S. Gambhir², R. S. Negrin⁵
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Radiology, Stanford University, Stanford, CA, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Division of Cardiovascular Medicine, Stanford University, Stanford, CA, ⁵Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
*Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
M. L. Ford, D. Liu
Emory University, Atlanta, GA
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…
2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang³, Y. Xiong¹, V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar⁴, L. Riella⁵, J. Bromberg⁶
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³U of Maryland, Minneapolis, MD, ⁴U of Minnesota, Minneapolis, MA, ⁵Harvard U, Boston, MA, ⁶Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…
2020 American Transplant Congress
CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel
N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…
2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…
2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti
UCSF, San Francisco, CA
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…
2019 American Transplant Congress
p40 Homodimer Indirectly Induce Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High-Risk Allografts via IL-15 Signaling
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4…
2019 American Transplant Congress
Treg Suppressor Function within Allografts is Required for Tolerance
J. Ossart, A. Pena, H. Dai, L. Bauer, A. Williams, G. Camirand
Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The role of regulatory CD4+Foxp3+ T cells (Treg) suppressor function within allografts in tolerance remains unclear. Thus, we sought to directly address: 1) whether…
2019 American Transplant Congress
Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes
K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹
¹Surgery, Medical University of South Carolina, Charleston, SC, ²Pathology, Royal Papworth Hospital NHS Trust, C, SC
*Purpose: Donor and recipient age at the time of lung transplantation (LTx) have been implicated in poor patient outcomes. The underlying mechanisms driving these effects…
2019 American Transplant Congress
Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8⁺T Cell Apoptosis in a Rat Liver Transplantation Model
X. Chen¹, Q. Yang¹, X. Li², Y. Deng¹, G. Chen¹, G. Wang¹
¹Department of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ²Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: In liver transplantation (LT), acute rejection (AR) remains a common complication that significantly shortens recipient survival although various immunosuppressors have been used in clinical…