Articles tagged "T cell graft infiltration"

2022 American Transplant Congress
p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts
H. Tsuda¹, A. Valujskikh², R. Fairchild³
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²The Cleveland Clinic Fdn, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
2022 American Transplant Congress
The Impact of Early Graft Infiltrating TCF-1^LowPD-1^HighCD8⁺ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model
T. Ota¹, R. Goto¹, T. Harada¹, Y. Ganchiku¹, M. Zaitsu¹, A. Forgioni¹, N. Kawamura², M. Watanabe², M. Fukai¹, T. Shimamura³, A. Taketomi¹
¹Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, ²Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
2022 American Transplant Congress
Presence of Infiltrating Regulatory T Cells in the Cardiac Xenografts and Their Potential Role in Graft Survival
A. K. Singh¹, C. E. Goerlich¹, G. Braileanu¹, A. Hershfeld¹, T. Zhang¹, I. Tatarov¹, B. Lewis¹, F. Sentz¹, D. Ayares², B. Griffith¹, M. M. Mohiuddin¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Revivicor Inc, Blacksburg, WV
*Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
2022 American Transplant Congress
Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets
R. Matsumoto
Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan
*Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
2022 American Transplant Congress
Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, E. Duggan¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Brustle¹, J. Stern¹, B. Piegari¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, D. Hajosi¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
2022 American Transplant Congress
Role of CD8⁺T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
J. Ge¹, E. Szuter¹, T. Yokose¹, I. Rosales², A. Cuenca³, P. Russell¹, J. Madsen¹, R. Colvin², A. Alessandrini¹
¹Center of Transplant Science, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA, ³Department of Surgery, Boston Children's Hospital, Boston, MA
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…
2022 American Transplant Congress
Effector T Cells Potentiate Treg Migration to Allografts
H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand
Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…
2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
2022 American Transplant Congress
Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. P. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…

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