ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell graft infiltration"

  • 2022 American Transplant Congress

    p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts

    H. Tsuda1, A. Valujskikh2, R. Fairchild3

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2The Cleveland Clinic Fdn, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
  • 2022 American Transplant Congress

    The Impact of Early Graft Infiltrating TCF-1LowPD-1HighCD8+ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model

    T. Ota1, R. Goto1, T. Harada1, Y. Ganchiku1, M. Zaitsu1, A. Forgioni1, N. Kawamura2, M. Watanabe2, M. Fukai1, T. Shimamura3, A. Taketomi1

    1Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, 2Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan

    *Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
  • 2022 American Transplant Congress

    Presence of Infiltrating Regulatory T Cells in the Cardiac Xenografts and Their Potential Role in Graft Survival

    A. K. Singh1, C. E. Goerlich1, G. Braileanu1, A. Hershfeld1, T. Zhang1, I. Tatarov1, B. Lewis1, F. Sentz1, D. Ayares2, B. Griffith1, M. M. Mohiuddin1

    1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor Inc, Blacksburg, WV

    *Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
  • 2022 American Transplant Congress

    Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets

    R. Matsumoto

    Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan

    *Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
  • 2022 American Transplant Congress

    Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response

    Z. Solhjou1, H. Zhang1, N. Younis1, J. Choi1, C. Deban1, A. Saad1, A. Halawi1, Z. Jing1, R. Bucala2, J. Azzi1

    1Brigham and Women's Hospital, Boston, MA, 2Yale University School of Medicine, New Haven, CT

    *Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
  • 2022 American Transplant Congress

    Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey

    H. Sakai1, E. Berglund1, S. Chaudhry1, Y. Kato1, E. Duggan1, J. Weiner1, P. Alonso-Guallart1, N. Llore1, K. Brustle1, J. Stern1, B. Piegari1, D. Ekanayake-Alper1, M. Martinez2, G. Pierre1, M. Danton1, S. Kofman1, D. Ordanes1, D. Hajosi1, J. Lefkowitch3, A. Iuga1, T. Kato4, A. Griesemer1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Departments of Pathology and Cell Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
  • 2022 American Transplant Congress

    Role of CD8+T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft

    J. Ge1, E. Szuter1, T. Yokose1, I. Rosales2, A. Cuenca3, P. Russell1, J. Madsen1, R. Colvin2, A. Alessandrini1

    1Center of Transplant Science, Massachusetts General Hospital, Boston, MA, 2Department of Pathology, Massachusetts General Hospital, Boston, MA, 3Department of Surgery, Boston Children's Hospital, Boston, MA

    *Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…
  • 2022 American Transplant Congress

    Effector T Cells Potentiate Treg Migration to Allografts

    H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand

    Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    *Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…
  • 2022 American Transplant Congress

    Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation

    S. Han1, X. Lai2, J. Wang1, L. VanOsdol3, C. Chen1, J. Mathew1, J. R. Leventhal4, Z. Zhang5

    1Northwestern University, Chicago, IL, 2Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, 3Comprehensive Transplant Center, Northwestern University, Chicago, IL, 4Surgery, Northwestern Medicine, Chicago, IL, 5Northwestern University Transplant Surgery, Chicago, IL

    *Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
  • 2022 American Transplant Congress

    Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts

    T. Salinas1, C. Li1, C. Snopkowski1, K. Chen1, S. Albakry1, S. P. Salvatore2, S. Seshan2, J. R. Lee1, M. Thangamani1, D. Dadhania1, M. Suthanthiran1

    1Nephrology, Weill Cornell-NYPH, New York, NY, 2Pathology, Weill Cornell-NYPH, New York, NY

    *Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…
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