Articles tagged "T cell graft infiltration"

2022 American Transplant Congress
Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation
B. Rocque¹, D. Sarode², A. Barbetta³, P. Singh⁴, C. Goldbeck⁴, C. Weaver⁵, O. Akbari⁴, R. Kohli⁵, J. Emamaullee⁶
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Keck School of Medicine of University of Southern California, Pasadena, CA, ³Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ⁴Keck School of Medicine of USC, Los Angeles, CA, ⁵Childrens Hospital Los Angeles, Los Angeles, CA, ⁶University of Southern California, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
A. Buxeda¹, L. Llinàs-Mallol¹, J. Gimeno², D. Redondo-Pachón¹, C. Arias-Cabrales¹, C. Burballa¹, A. Puche², M. Pérez-Sáez¹, J. Pascual³, M. Crespo¹
¹Nephrology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ²Pathology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ³Nephrology Department, Hospital Universitario 12 de Octubre. Institute Mar for Medical Research (IMIM), Madrid, Spain
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…
2022 American Transplant Congress
TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3⁺ Treg
C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
2021 American Transplant Congress
P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
2021 American Transplant Congress
Dynamic Reconstitution of Recipient Resident Memory T Cell Repertoire After Human Intestinal Transplantation
W. Jiao, M. Martinez, J. Zuber, A. Obradovic, R. Jones, E. Waffarn, Z. Wang, A. Gorur, K. Rogers, T. Kato, Y. Shen, J. Fu, M. Sykes
Columbia University, New York, NY
*Purpose: Our studies in intestinal transplant (ITx) recipients demonstrated that donor T cell blood macrochimerism(peak level ≥4%) is associated with slower graft T cell replacement…
2021 American Transplant Congress
Utility of Follow-up Biopsies After Acute Rejection in Pediatric Kidney Transplantation
S. S. Raza¹, V. Hauptfeld-Dolejsek¹, F. Rosenblum¹, E. C. Mroczek-Musulman², D. R. Kelly², M. Seifert¹
¹Department of Nephrology, UAB School of Medicine, Birmingham, AL, ²Children’s of Alabama, Birmingham, AL
*Purpose: Treatment of acute kidney transplant rejection in children is often guided by creatinine-based estimates of GFR (eGFR) that may lack sensitivity to determine the…
2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
K. Bruestle¹, R. Tavare², F. Fredriksson¹, E. Duggan¹, F. Huang¹, B. Bhola¹, J. Giurleo², R. Foster², P. Krueger², M. Dobosz², D. Ekanayake-Alper¹, H. Sakai¹, B. Piegari¹, J. Castrillion¹, S. M. Coley¹, O. Harari², A. Mintz¹, D. Ma², A. Griesemer¹
¹Columbia University Medical Center, New York City, NY, ²Regeneron Pharmaceuticals, Inc, New York City, NY
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
J. Torrealba, S. Moore, S. Sathirareuangchai, L. De Las Casas, Q. Cai
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2020 American Transplant Congress
Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection
T. Hirai¹, A. Mayer², T. W. Nobashi², Z. Xiao², T. Udagawa³, K. Seo⁴, F. Simonetta⁵, J. Baker⁵, A. Cheng³, S. S. Gambhir², R. S. Negrin⁵
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Radiology, Stanford University, Stanford, CA, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Division of Cardiovascular Medicine, Stanford University, Stanford, CA, ⁵Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
*Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…