Articles tagged "T cell graft infiltration"

2022 American Transplant Congress
Effector T Cells Potentiate Treg Migration to Allografts
H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand
Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…
2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
2022 American Transplant Congress
Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. P. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…
2021 American Transplant Congress
Utility of Follow-up Biopsies After Acute Rejection in Pediatric Kidney Transplantation
S. S. Raza¹, V. Hauptfeld-Dolejsek¹, F. Rosenblum¹, E. C. Mroczek-Musulman², D. R. Kelly², M. Seifert¹
¹Department of Nephrology, UAB School of Medicine, Birmingham, AL, ²Children’s of Alabama, Birmingham, AL
*Purpose: Treatment of acute kidney transplant rejection in children is often guided by creatinine-based estimates of GFR (eGFR) that may lack sensitivity to determine the…
2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
K. Bruestle¹, R. Tavare², F. Fredriksson¹, E. Duggan¹, F. Huang¹, B. Bhola¹, J. Giurleo², R. Foster², P. Krueger², M. Dobosz², D. Ekanayake-Alper¹, H. Sakai¹, B. Piegari¹, J. Castrillion¹, S. M. Coley¹, O. Harari², A. Mintz¹, D. Ma², A. Griesemer¹
¹Columbia University Medical Center, New York City, NY, ²Regeneron Pharmaceuticals, Inc, New York City, NY
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
J. Torrealba, S. Moore, S. Sathirareuangchai, L. De Las Casas, Q. Cai
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2021 American Transplant Congress
P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
2021 American Transplant Congress
Dynamic Reconstitution of Recipient Resident Memory T Cell Repertoire After Human Intestinal Transplantation
W. Jiao, M. Martinez, J. Zuber, A. Obradovic, R. Jones, E. Waffarn, Z. Wang, A. Gorur, K. Rogers, T. Kato, Y. Shen, J. Fu, M. Sykes
Columbia University, New York, NY
*Purpose: Our studies in intestinal transplant (ITx) recipients demonstrated that donor T cell blood macrochimerism(peak level ≥4%) is associated with slower graft T cell replacement…
2020 American Transplant Congress
Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection
T. Hirai¹, A. Mayer², T. W. Nobashi², Z. Xiao², T. Udagawa³, K. Seo⁴, F. Simonetta⁵, J. Baker⁵, A. Cheng³, S. S. Gambhir², R. S. Negrin⁵
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Radiology, Stanford University, Stanford, CA, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Division of Cardiovascular Medicine, Stanford University, Stanford, CA, ⁵Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
*Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…