Articles tagged "T cell graft infiltration"

2022 American Transplant Congress
Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation
B. Rocque¹, D. Sarode², A. Barbetta³, P. Singh⁴, C. Goldbeck⁴, C. Weaver⁵, O. Akbari⁴, R. Kohli⁵, J. Emamaullee⁶
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Keck School of Medicine of University of Southern California, Pasadena, CA, ³Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ⁴Keck School of Medicine of USC, Los Angeles, CA, ⁵Childrens Hospital Los Angeles, Los Angeles, CA, ⁶University of Southern California, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
A. Buxeda¹, L. Llinàs-Mallol¹, J. Gimeno², D. Redondo-Pachón¹, C. Arias-Cabrales¹, C. Burballa¹, A. Puche², M. Pérez-Sáez¹, J. Pascual³, M. Crespo¹
¹Nephrology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ²Pathology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, ³Nephrology Department, Hospital Universitario 12 de Octubre. Institute Mar for Medical Research (IMIM), Madrid, Spain
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…
2022 American Transplant Congress
TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3⁺ Treg
C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
2022 American Transplant Congress
p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts
H. Tsuda¹, A. Valujskikh², R. Fairchild³
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²The Cleveland Clinic Fdn, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
2022 American Transplant Congress
The Impact of Early Graft Infiltrating TCF-1^LowPD-1^HighCD8⁺ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model
T. Ota¹, R. Goto¹, T. Harada¹, Y. Ganchiku¹, M. Zaitsu¹, A. Forgioni¹, N. Kawamura², M. Watanabe², M. Fukai¹, T. Shimamura³, A. Taketomi¹
¹Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, ²Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
2022 American Transplant Congress
Presence of Infiltrating Regulatory T Cells in the Cardiac Xenografts and Their Potential Role in Graft Survival
A. K. Singh¹, C. E. Goerlich¹, G. Braileanu¹, A. Hershfeld¹, T. Zhang¹, I. Tatarov¹, B. Lewis¹, F. Sentz¹, D. Ayares², B. Griffith¹, M. M. Mohiuddin¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Revivicor Inc, Blacksburg, WV
*Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
2022 American Transplant Congress
Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets
R. Matsumoto
Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan
*Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
2022 American Transplant Congress
Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, E. Duggan¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Brustle¹, J. Stern¹, B. Piegari¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, D. Hajosi¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
2022 American Transplant Congress
Role of CD8⁺T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
J. Ge¹, E. Szuter¹, T. Yokose¹, I. Rosales², A. Cuenca³, P. Russell¹, J. Madsen¹, R. Colvin², A. Alessandrini¹
¹Center of Transplant Science, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA, ³Department of Surgery, Boston Children's Hospital, Boston, MA
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…

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