2018 American Transplant Congress
Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality
1Thomas E. Starzl Transplantation Institute, Pittsburgh; 2Adaptive Biotechnologies, Seattle.
Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…2017 American Transplant Congress
Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.
The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…2017 American Transplant Congress
Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.
1Brigham and Women's Hospital, Boston; 2Broad Institute of MIT and Harvard, Cambridge
BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…2017 American Transplant Congress
Recognition of Islet Xenografts In Vivo by Non-Obese Diabetic (NOD) Insulin-Specific CD4 T Cells.
Surgery and Immunology, University of Colorado Denver, Aurora, CO
Xenogeneic islet transplantation has been one ongoing goal for treating autoimmune Type 1 diabetes. Autoimmune diabetes involves a T cell response restricted to the host…2017 American Transplant Congress
Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.
Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…2015 American Transplant Congress
Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)
BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…2015 American Transplant Congress
Changes in Immunophenotypes After Conversion from Calcineurin Inhibitors to mTOR Inhibitors in Renal Transplant Recipients
Chronic toxicity of calcineurin inhibitors (CNI) is one of the major causes of chronic allograft loss. Conversion from CNI to mTOR ((mammalian target of rapamycin)…2015 American Transplant Congress
Chimeric Patients Who Undergo Combined Facilitating Cell-Enriched/HSC/Renal Transplant Exhibit Robust TCR Repertoire
Combined donor kidney plus facilitating cell enriched hematopoietic stem cell (FCRx) transplants (Tx), after low intensity conditioning with fludarabine, 200-cGy total body irradiation and cyclophosphamide…
American Transplant Congress abstracts