2022 American Transplant Congress
The Impact of T-Cell Receptor Diversity in Acute Kidney Transplant Rejection
1UCSF, San Francisco, CA, 2Adaptive Biotechnologies, Seattle, WA
*Purpose: Recent developments in T-cell receptor (TCR) immunosequencing allow for analysis of alloreactive human T-cell populations both before and after engraftment. In this study, we…2022 American Transplant Congress
Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis
*Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…2022 American Transplant Congress
Autencoder, a Novel Computational Tool to Score T Cell Clones Demonstrates Biopsy T Cell Clones Are Not Represented in the Peripheral Blood
Washington University, St Louis, MO
*Purpose: Antibody-mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. The generation and…2021 American Transplant Congress
Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring
*Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…2021 American Transplant Congress
Kidney Transplant Rejection Can Be Diagnosed or Even Predicted by Tracking Donor Reactive T Cell Clones in Post-transplant Samples
*Purpose: To test if kidney transplant (KTx) rejection can be diagnosed by monitoring for donor reactive T-cell (DRTC) clones in post-transplant (post-tx) biopsy and non-invasively…2020 American Transplant Congress
Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation
*Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…2019 American Transplant Congress
Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation
*Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…2019 American Transplant Congress
T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection
*Purpose: Tissue infiltration of T-cells is the hallmark of acute cellular graft rejection. Next generation sequencing of T-cell receptors enables in depth analysis of the…2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…2018 American Transplant Congress
Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy
Medicine, Columbia University Medical Center, New York, NY.
Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…
American Transplant Congress abstracts