ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell clones"

  • 2020 American Transplant Congress

    Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation

    C. Aschauer1, K. Jelencsics1, K. Hu1, R. Reindl-Schwaighofer1, J. Vetter2, A. Heinzel1, A. Kainz1, G. Gualdoni1, S. Schaller2, S. Winkler2, R. Oberbauer1

    1Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, 2Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg im Muehlkreis, Austria

    *Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…
  • 2019 American Transplant Congress

    Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation

    J. Fu1, J. Zuber1, B. Shonts1, A. Obradovic1, K. Frangaj1, E. E. Waffarn1, S. Lau1, T. M. Savage1, S. Yang1, K. Rogers1, P. Satwani2, S. Ho1, Y. Shen3, A. Griesemer4, M. Martinez2, T. Kato4, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Systems Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…
  • 2019 American Transplant Congress

    T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection

    R. Reindl-Schwaighofer1, J. Vetter2, J. Weinberger3, S. Schaller2, A. Heinzel1, G. Gualdoni1, C. Aschauer1, K. Jelencsics1, K. Hu1, S. Winkler2, R. Oberbauer1

    1Nephrology, Medical University of Vienna, Vienna, Austria, 2University of Applied Sciences Upper Austria, Hagenberg, Austria, 3Austrian Red Cross, Vienna, Austria

    *Purpose: Tissue infiltration of T-cells is the hallmark of acute cellular graft rejection. Next generation sequencing of T-cell receptors enables in depth analysis of the…
  • 2019 American Transplant Congress

    Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy

    M. V. Habal1, A. Myung2, H. Yan2, S. Rao2, S. Lin2, S. See2, P. Roy2, R. Shihab2, C. Marboe3, S. Restaino1, A. Han2, M. Givertz4, J. C. Madsen5, L. Addonizio1, M. Farr1, E. Zorn2

    1Cardiology, Columbia University Medical Center, New York, NY, 2Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 3Pathology, Columbia University Medical Center, New York, NY, 4Cardiology, Brigham and Women's Hospital, Boston, MA, 5Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…
  • 2018 American Transplant Congress

    Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy

    M. Habal, A. Myung, H. Yan, S. Rao, S. Lin, P. Colombo, C. Marboe, S. Restaino, A. Han, M. Farr, E. Zorn.

    Medicine, Columbia University Medical Center, New York, NY.

    Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…
  • 2018 American Transplant Congress

    Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality

    C. Macedo,1 M. Yamada,1 X. Gu,1 M. Suchoroski,2 D. Hamm,2 M. Kaplan,2 D. Metes.1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh; 2Adaptive Biotechnologies, Seattle.

    Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…
  • 2017 American Transplant Congress

    Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.

    P. Szabolcs,1,2 X. Chen,1 M. Hill.1

    1BMT and Cell Therapy, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; 2Immunology, University of Pittsburgh, Pittsburgh, PA

    The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…
  • 2017 American Transplant Congress

    Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.

    T. Win,1 N. Murakami,2 I. Avraham-Davidi,1 J. Teague,1 E. Lowry,1 R. Lopdrup,1 E. Bueno,1 A. Chandraker,1 L. Riella,1 B. Pomahac,1 R. Clark.1

    1Brigham and Women's Hospital, Boston; 2Broad Institute of MIT and Harvard, Cambridge

    BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…
  • 2017 American Transplant Congress

    Recognition of Islet Xenografts In Vivo by Non-Obese Diabetic (NOD) Insulin-Specific CD4 T Cells.

    R. Gill, W. Dale, M. Crawford.

    Surgery and Immunology, University of Colorado Denver, Aurora, CO

    Xenogeneic islet transplantation has been one ongoing goal for treating autoimmune Type 1 diabetes. Autoimmune diabetes involves a T cell response restricted to the host…
  • 2017 American Transplant Congress

    Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.

    H. Zhang,1 Y. Zhao,1 Q. Tang,3 A. Thomson.1,2

    1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 3Department of Surgery, UCSF, San Francisco, CA

    Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…
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