2020 American Transplant Congress
Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation
*Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…2019 American Transplant Congress
Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation
*Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…2019 American Transplant Congress
T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection
*Purpose: Tissue infiltration of T-cells is the hallmark of acute cellular graft rejection. Next generation sequencing of T-cell receptors enables in depth analysis of the…2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…2018 American Transplant Congress
Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy
Medicine, Columbia University Medical Center, New York, NY.
Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…2018 American Transplant Congress
Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality
1Thomas E. Starzl Transplantation Institute, Pittsburgh; 2Adaptive Biotechnologies, Seattle.
Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…2017 American Transplant Congress
Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.
The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…2017 American Transplant Congress
Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.
1Brigham and Women's Hospital, Boston; 2Broad Institute of MIT and Harvard, Cambridge
BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…2017 American Transplant Congress
Recognition of Islet Xenografts In Vivo by Non-Obese Diabetic (NOD) Insulin-Specific CD4 T Cells.
Surgery and Immunology, University of Colorado Denver, Aurora, CO
Xenogeneic islet transplantation has been one ongoing goal for treating autoimmune Type 1 diabetes. Autoimmune diabetes involves a T cell response restricted to the host…2017 American Transplant Congress
Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.
Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…
American Transplant Congress abstracts