2019 American Transplant Congress
Extracorporeal Photopheresis for Specific Immune Tolerance Responses in Heart Transplant Recipients
*Purpose: Extracorporeal photopheresis (ECP) treatment following heart transplantation (HTx) may induce transplant tolerance. A monitoring tool for successful ECP treatment would allow determination of patient-specific…2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…2019 American Transplant Congress
Resistance of T Follicular Helper Cells to Depletion by Anti-Thymocyte Globulin
*Purpose: T follicular helper (Tfh) cells are a subset of CD4+ T cells that specializes in providing help for germinal center (GC) reactions where B…2019 American Transplant Congress
Implication of Melanocortin Receptors in Alloimmunity
Transplantation Research Center, Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: Recent studies have indicated the importance of the melanocortin pathway in the regulation of immune responses. In particular, the role that melanocortin receptors (MCRs)…2019 American Transplant Congress
A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance
The Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Ikaros is a transcriptional repressor encoded by the Ikzf1 gene that was recently identified as the pharmacologic target of thalidomide analogs in successful therapy…2019 American Transplant Congress
SIRPα Typing as a Potential Tool for Risk Stratification in Kidney Transplantation
Transplant Immunology Laboratory, Northwestern University, Chicago, IL
*Purpose: To determine if mismatches in the SIRPα receptor, associated with initiate innate alloresponses in animal models, may impact human kidney transplantation outcome.*Methods: To avoid…2019 American Transplant Congress
Evaluating Allo-Specific CD57+ T Cells during Memory and Proliferative Responses
Department of Surgery, Duke University, Durham, NC
*Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…2019 American Transplant Congress
Single Nucleotide Polymorphisms in NFACT1 rs2290154 Associated with the Risk of T Cell-Mediated Rejection of Recipients Following Kidney Transplantation
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to investigate the potential associations between the single nucleotide polymorphisms (SNPs) in NFATC1 and the risk of T cell-mediated rejection (TCMR)…2019 American Transplant Congress
IFNAR Signaling Augments Plasmacytoid Dendritic Cell Activation during Costimulation Independent Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new transplant immunosuppression strategy offering improved long-term patient and allograft survival without the nephrotoxicity of calcineurin inhibitors. However,…2019 American Transplant Congress
Type-1 Interferons Impair the Key Immunoregulatory Activity of IL-10 in the Promotion of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. Despite the identification of type-1 interferons (TI-IFN) as…
- « Previous Page
- 1
- …
- 7
- 8
- 9
- 10
- 11
- …
- 20
- Next Page »