2019 American Transplant Congress
SIRPα Typing as a Potential Tool for Risk Stratification in Kidney Transplantation
Transplant Immunology Laboratory, Northwestern University, Chicago, IL
*Purpose: To determine if mismatches in the SIRPα receptor, associated with initiate innate alloresponses in animal models, may impact human kidney transplantation outcome.*Methods: To avoid…2019 American Transplant Congress
Evaluating Allo-Specific CD57+ T Cells during Memory and Proliferative Responses
Department of Surgery, Duke University, Durham, NC
*Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…2019 American Transplant Congress
Single Nucleotide Polymorphisms in NFACT1 rs2290154 Associated with the Risk of T Cell-Mediated Rejection of Recipients Following Kidney Transplantation
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to investigate the potential associations between the single nucleotide polymorphisms (SNPs) in NFATC1 and the risk of T cell-mediated rejection (TCMR)…2019 American Transplant Congress
IFNAR Signaling Augments Plasmacytoid Dendritic Cell Activation during Costimulation Independent Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new transplant immunosuppression strategy offering improved long-term patient and allograft survival without the nephrotoxicity of calcineurin inhibitors. However,…2019 American Transplant Congress
Type-1 Interferons Impair the Key Immunoregulatory Activity of IL-10 in the Promotion of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. Despite the identification of type-1 interferons (TI-IFN) as…2019 American Transplant Congress
The Adapter Protein TSAd Regulates Mitochondrial Lck Activity and is Potent to Enhance Immunoregulation Following Transplantation
*Purpose: T cell Specific Adaptor Protein (TSAd, encoded by the SH2D2A gene) is an intracellular adapter molecule that binds Lck and functions to elicit T…2019 American Transplant Congress
BTLA Suppressed Acute Rejection by Regulating T Cell Receptor Downstream Signal Pathways and Cytokine Production in Renal Transplant and Contributed to Prolongation of Allograft Survival
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: The present study aimed to investigate the role of BTLA in the progress of acute rejection after kidney transplantation.*Methods: In human allograft renal transplanted…2019 American Transplant Congress
The Immunomodulatory Role of Type I Interferons in Alloimmunity
Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Despite a growing body of work on type 1 interferon (IFNAR1) signaling, there is a lack of consensus on the immunological properties of type…2019 American Transplant Congress
Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation
*Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…2019 American Transplant Congress
A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation
*Purpose: Tregs play a critical role in immune tolerance. If Tregs can be administered to patients suffering from immune disorders, most therapies employing existing immunosuppressants…
- « Previous Page
- 1
- …
- 6
- 7
- 8
- 9
- 10
- …
- 20
- Next Page »