Articles tagged "T cell activation"

2015 American Transplant Congress
A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA
G. Furtmüller,¹ M. Fryer,¹ B. Oh,¹ S. Ganguly,² J. Izzi,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ³Department of Research Animal Resources, Johns Hopkins University, Baltimore, MD.
Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…
2015 American Transplant Congress
Immunomodulatory Effects of Neuropilin-2 On T Cells
H. Nakayama,^1,2 N. Kochupurakkal,¹ S. Bruneau,¹ D. Bielenberg,² M. Klagsbrun,² D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA; ²Vascular Biology Program, Boston Children's Hospital, Boston, MA.
Axonal guidance molecules are expressed within the immune system and elicit anti-inflammatory effects with potential to target auto- and alloimmunity. The neuropilin (NRP) family receptors…
2015 American Transplant Congress
Induction of HO-1 High Expression Enhances the Capacity of Immature Dendritic Cells to Modulate Alloimmune Responses
G. Chen, Y. Zhao, L. Wang, S. Chen, X. Huang.
Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Background: It has been reported that HO-1 is critical for tolerogenic dendritic cells (tolDCs) to suppress T cell responses and tolDCs will lost their immunoregulatory…
2015 American Transplant Congress
Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses
V. Agashe,¹ M. Keller,² L. Haynes,¹ E. Jankowska-Gan,¹ J. Sullivan,¹ J. Kernien,¹ H. Suzuki,³ D. Wilkes,⁴ W. Burlingham.¹
¹Surgery, UW Madison, Madison, WI; ²Tulane University, New Orleans, LA; ³Chiba Graduate School of Medicine, Chiba, Japan; ⁴Indiana University School of Medicine, Indianapolis, IN.
Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…
2015 American Transplant Congress
Interleukin-17A Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Grey,⁵ C. Hope,^1,2 R. Carroll,^1,4 S. Gronthos,^3,6 P. Coates.^1,2,3,4
¹Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia; ⁴Central Northern Adelaide Renal Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ⁵Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; ⁶Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Interferon-gamma preactivated mesenchymal stem cells (MSC-γ) are highly immunosuppressive but immunogenic in vivo due to their inherent expression of major histocompatibility (MHC) molecules. We modified…
2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
S. Iida,¹ C. Su,¹ T. Abe,¹ K. Tanabe,² R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…
2015 American Transplant Congress
Tissue Engineering Human Kidneys for Costimulation Blockade
L. Brasile,¹ N. Henry,¹ A. Meyer,¹ B. Stubenitsky.²
¹BREONICS, Inc., Watervliet, NY; ²Surgery, University of Utrecht, Utrecht, Netherlands.
Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…