ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2015 American Transplant Congress

    Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation

    E. Lee, H. Kim, G. Demirci.

    Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA.

    Introduction: Neuropilin-1 (NRP1) is a co-receptor for a variety of ligand families including VEGF, EGF and semaphorins all of which are often produced by malignant…
  • 2015 American Transplant Congress

    Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts

    M. Tonsho,1 G. Benichou,1 R. Smith,2 R. Colvin,2 J. Madsen.1,3

    1MGH Transplant Center, Massachusetts General Hospital, Boston, MA; 2Pathology, Massachusetts General Hospital, Boston, MA; 3Cardiac Surgery, Massachusetts General Hospital, Boston, MA.

    Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
  • 2015 American Transplant Congress

    Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates

    K. Hotta, A. Aoyama, P. Putheti, Y. Yamada, T. Ohura, R. Colvin, B. Cosimi, G. Benichou, T. Strom, T. Kawai.

    Transplant Center, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…
  • 2015 American Transplant Congress

    Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective

    M. Parkes,1 P. Halloran,1 L. Hidalgo.2

    1Department of Medicine, University of Alberta, Edmonton, AB, Canada; 2Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.

    AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…
  • 2015 American Transplant Congress

    2B4 Expression on Human CD4+ Memory T Cells Is Associated With Functional Impairment

    C. Chen, S. Laurie, J. Lyons, C. Coopersmith, M. Ford.

    Emory Transplant Center, Emory University, Atlata, GA.

    The SLAM family receptor 2B4 is expressed primarily on NK cells and memory CD8+ T cells. In prior studies, we found that 2B4 was upregulated…
  • 2015 American Transplant Congress

    IL-17 Production Influenced by Induction Therapy With ATG

    D. Abendroth,1 M. Marzinzig,1 J. Kaden.2

    1Center of Surgery, University of Ulm, Ulm, Germany; 2Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany.

    Introduction Immune-mediated rejection remains the most important cause of graft failure. Recently, a newly identified CD4+ T cell subset, Th17, distinct from Th1 or Th2,…
  • 2015 American Transplant Congress

    Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+ T Cells in Selective Lymphoid Compartments

    S. Laurie, D. Liu, M. Ford.

    Department of Surgery, Emory University, Atlanta, GA.

    2B4 is an immunoglobulin superfamily member expressed constitutively on NK cells, and inducibly on some CD8+ T cells. We recently showed in a murine skin…
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