Articles tagged "T cell activation"

2015 American Transplant Congress
Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation
J. Marino,¹ P. Crosby Bertorini,¹ M. Uehara,² J. Paster,¹ S. Mordecai,³ W.-H. Liu,¹ L. Liu,¹ R. Abdi,² G. Tocco,¹ J. Kim,¹ J. Markmann,¹ G. Benichou.¹
¹Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA; ²Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA; ³Department of Pathology, Flow and Imaging Cytometry Core, Massachusetts General Hospital, Boston, MA.
We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…
2015 American Transplant Congress
BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses
M. Chen,¹ Q. Li,¹ W. Stohl,² S. Zheng,² X. He,¹ Z. Guo.¹
¹Organ Transplant Center, 1st affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…
2015 American Transplant Congress
Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation
M. Zhang,^1,2 H. Wang,¹ N. Navarro-Alvarez,¹ Y. Zheng,² Y.-G. Yang.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²First Hospital, Jilin University, Changchun, Jilin, China.
Background: The interspecies incompatibility of CD47 is an important mechanism triggering rejection of cellular xenografts, including both hematopoietic and non-hematopoietic cells, by recipient macrophages. Our…
2015 American Transplant Congress
CD27^low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8⁺ T Cell Responses Through Controlling Graft-Derived Donor DCs
A. Kroemer,^1,2 M. Lantow,¹ E. Eggenhofer,¹ M. Sabet-Baktach,¹ P. Renner,¹ H. Schlitt,¹ E. Geissler.¹
¹Department of Surgery, University Hospital Regensburg, Regensburg, Germany; ²Georgetown Transplant Institute, Washington, DC.
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…
2015 American Transplant Congress
Assessment of Viral-Specific Memory T Cell Responses and Infection Rates in HLA-Sensitized (HS) Kidney Transplant Patients (Tx Pts) Treated With Everolimus & Low-Dose Tacrolimus (Eve/Tac)
S. Ge, J. Kahwaji, M. Chu, A. Karasyov, M. Castro, E. Hayrapetyan, D. Lovato, D. Thomas, J. Choi, S. Louie, A. Vo, S. Jordan, M. Toyoda.
Transplant Immunology & Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles.
Background: mTOR inhibitors stimulate viral-specific memory CD8+ T cell differentiation and increase viral clearance in infected Tx pts. HS pts desensitized (DES) with IVIG +…
2015 American Transplant Congress
Th-17 Alloimune Responses in Renal Allograft Biopsies from Recipients of Kidney Transplants Using Extended Criteria Donors During Acute T-Cell Mediated Rejection
M. Matignon,^1,2 A. Aissat,³ F. Canoui-Poitrine,⁴ C. Grondin,² D. Desvaux,⁵ D. Saadoun,⁶ P. Lang,^1,2 J. Cohen,² P. Grimbert.^1,2
¹Nephrology Transplantation, APHP, Créteil, France; ²U955 Team 21, INSERM, Créteil, France; ³U955 Team 11, INSERM, Créteil, France; ⁴Public Health, APHP, Créteil, France; ⁵Anatomopathology, APHP, Créteil, France; ⁶Internal Medicine, APHP Pitié Salpêtrière, Paris, France.
Although renal transplantation using expanded criteria donors has become a common practice, immune responses related to immunosenescence in those kidney allografts have not been studied…
2015 American Transplant Congress
Allo-Stimulated Interferon-γ Release and Natural Killer Cell Function Defines and Risk Stratifies Cancer Development in Kidney Transplant Recipients Who Have Cancer Post-transplantation
C. Hope,^1,2 A. Fuss,^1,2 W. Hanf,¹ P. Coates,^1,2 P. Heeger,³ R. Carroll.^1,2
¹The Centre for Clinical and Experimental Transplantation (CCET), Central Northern Adelaide Renal and Transplantation Services (CNARTS), Adelaide, South Australia, Australia; ²Medicine, The University of Adelaide, Adelaide, South Australia, Australia; ³Icahn School of Medicine, The Recanati-Miller Transplant Institute, New York City, NY.
Reducing immunosuppression is efficacious in primary prevention of cancer in Kidney Transplant Recipients (KTR) but can precipitate graft rejection. Conventional immunosuppressive drug monitoring fails to…