2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…2015 American Transplant Congress
Dual PI3K-mTOR Inhibition on Human T Cell Activation, Proliferation, and Differentiation: The First Step in the Development of New Immunosuppressants
Background: Regulatory T lymphocytes (Tregs) contribute to transplant tolerance. We have demonstrated that the inhibition of PI3K-mTOR pathway has a major role in the differentiation…2015 American Transplant Congress
IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections Through Induction of IL-13 Production by CD4+ T Cells
Susceptibility to systemic Candida albicans infection is determined not only by immune resistance but also by the ability to control Candida-induced immunopathologies. We previously showed…2015 American Transplant Congress
Negative Effects of Being Obese or Overweight on T Regulatory (Treg) Cell Suppressive Function in Patients Listed for Lung Transplantation (Tx)
Aim: Obese and overweight patients may be prone to adverse outcomes following lung Tx. We sought to determine the relationship between body mass index (BMI)…2015 American Transplant Congress
A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA
Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…2015 American Transplant Congress
Immunomodulatory Effects of Neuropilin-2 On T Cells
Axonal guidance molecules are expressed within the immune system and elicit anti-inflammatory effects with potential to target auto- and alloimmunity. The neuropilin (NRP) family receptors…2015 American Transplant Congress
Induction of HO-1 High Expression Enhances the Capacity of Immature Dendritic Cells to Modulate Alloimmune Responses
Background: It has been reported that HO-1 is critical for tolerogenic dendritic cells (tolDCs) to suppress T cell responses and tolDCs will lost their immunoregulatory…2015 American Transplant Congress
Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses
Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…2015 American Transplant Congress
Interleukin-17A Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
Interferon-gamma preactivated mesenchymal stem cells (MSC-γ) are highly immunosuppressive but immunogenic in vivo due to their inherent expression of major histocompatibility (MHC) molecules. We modified…2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…
American Transplant Congress abstracts