Th-17 Alloimune Responses in Renal Allograft Biopsies from Recipients of Kidney Transplants Using Extended Criteria Donors During Acute T-Cell Mediated Rejection
1Nephrology Transplantation, APHP, Créteil, France
2U955 Team 21, INSERM, Créteil, France
3U955 Team 11, INSERM, Créteil, France
4Public Health, APHP, Créteil, France
5Anatomopathology, APHP, Créteil, France
6Internal Medicine, APHP Pitié
Salpêtrière, Paris, France.
Meeting: 2015 American Transplant Congress
Abstract number: 457
Keywords: Kidney transplantation, T cell activation, Transcription factors
Session Information
Session Name: Concurrent Session: Kidney: Acute Cellular Rejection
Session Type: Concurrent Session
Date: Tuesday, May 5, 2015
Session Time: 4:00pm-5:30pm
Presentation Time: 4:36pm-4:48pm
Location: Room 121-AB
Although renal transplantation using expanded criteria donors has become a common practice, immune responses related to immunosenescence in those kidney allografts have not been studied yet in humans. We performed a retrospective molecular analysis of the T cell immune response in 43 kidney biopsies from patients with acute T-cell mediated rejection including 25 from recipients engrafted with a kidney from expanded criteria donor and 18 from recipients grafted with optimal kidney allograft. The clinical, transplant and acute T-cell mediated rejection characteristics of both groups were similar at baseline. The expression of RORγt, Il-17 and T-bet mRNA was significantly higher in the elderly than in the optimal group (p=0.02, p=0.036 and p=0.01, respectively). Foxp3 mRNA levels were significantly higher in elderly patients experiencing successful acute T-cell mediated rejection reversal (p=0.03). The presence of IL-17 mRNA was strongly associated with non-successful reversal in elderly patients (p=0.008). Patients with mRNA IL17 expression detection and low mRNA Foxp3 expression experiencing significantly more treatment failure (87.5%) than patients with no mRNA IL17 expression and/or high mRNA Foxp3 (26.7%; p=0.017). Our study suggests that Th17 pathway is involved in pathogenesis and prognosis of acute T-cell mediated rejection in recipients of ECD allograft.
To cite this abstract in AMA style:
Matignon M, Aissat A, Canoui-Poitrine F, Grondin C, Desvaux D, Saadoun D, Lang P, Cohen J, Grimbert P. Th-17 Alloimune Responses in Renal Allograft Biopsies from Recipients of Kidney Transplants Using Extended Criteria Donors During Acute T-Cell Mediated Rejection [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/th-17-alloimune-responses-in-renal-allograft-biopsies-from-recipients-of-kidney-transplants-using-extended-criteria-donors-during-acute-t-cell-mediated-rejection/. Accessed December 2, 2024.« Back to 2015 American Transplant Congress