Articles tagged "T cell activation"

2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
F. Peters,¹ A. Peeters,¹ L. Hofland,² M. Betjes,¹ K. Boer,¹ C. Baan.¹
¹Nephrology and Transplantation, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Endocrinology, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…
2017 American Transplant Congress
Contribution of γδ T-Cell Subsets and IL-17A Release to Ischemia Reperfusion Injury (IRI) and Kidney Allograft Rejection in Mice.
A. Thorenz,¹ S. Rong,¹ N. Völker,¹ R. Chen,¹ J. Bräsen,² H. Haller,¹ C. Klemann,³ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, Hannover Medical School, Hannover, Germany; ³Pediatric Surgery, Hannover Medical School, Hannover, Germany
Ischemia reperfusion injury (IRI) contributes to acute allograft injury and to delayed graft function (DGF) which is a trigger for acute rejection after kidney transplantation…
2017 American Transplant Congress
Evaluation of Function and TCR signaling Profile of CD57⁺ T Cells in Allo-Specific Immunity.
H. Xu,¹ T. Brennan,¹ Q. Li,² A. Kirk.¹
¹Department of Surgery, Duke University School of Medicine, Durham, NC; ²Department of Immunology, Duke University School of Medicine, Durham, NC
Our studies have showed that CD57+ cells are resistant to B7 costimulation blockade (CoB). We hypothesize that CD57+ cells are highly sensitive to T cell…
2016 American Transplant Congress
Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.
N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Costimulation blockade prolongs graft survival but does not induce tolerance in primates, and mechanisms of rejection are incompletely understood. Here we evaluate changes in…
2016 American Transplant Congress
Blockade of the ASC Coreceptor Enhances Hematopoietic Stem Cell Engraftment.
R. Elahimehr, S. Kasimsetti, A. Shigeoka, D. McKay.
UCSD, San Diego.
Purpose: HSC engraftment is essential for successful bone marrow transplantation, and successful HSC engraftment allows for induction of tolerance to solid organ allografts. Engrafted HSCs…
2016 American Transplant Congress
Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.
J. Ruben,¹ G. Garcia-Romo,¹ E. Breman,¹ S. van der Kooij,¹ A. Redeker,² R. Arens,² C. van Kooten.¹
¹Nephrology, Leiden University Medical Centre, Leiden, Netherlands; ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
L. Wang,¹ A. Beeler,² S. Dahiya,¹ R. Han,¹ W. Hancock.¹
¹CHOP & UPenn, Philadelphia, PA; ²Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…
2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Radiology, Medical School, Hannover, Germany; ³Paediatric Surgery, Medical School, Hannover, Germany; ⁴Central Animal Facility, Medical School, Hannover, Germany; ⁵Microbiology, Medical School, Hannover, Germany.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
M. Seyda, H. Li, G. Liu, M. Quante, H. Uehara, J. Schuitenmaker, A. Elkhal, S. Tullius.
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Boston.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…
2016 American Transplant Congress
Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.
T. Thornley,¹ P. Kyriazis,¹ K. Agarwal,¹ Z. Fang,¹ L. Ma,¹ V. Chipashvili,¹ M. Koulmanda,^1,2 T. Strom.^1,2
¹Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA.
We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…