2019 American Transplant Congress
The Adapter Protein TSAd Regulates Mitochondrial Lck Activity and is Potent to Enhance Immunoregulation Following Transplantation
*Purpose: T cell Specific Adaptor Protein (TSAd, encoded by the SH2D2A gene) is an intracellular adapter molecule that binds Lck and functions to elicit T…2019 American Transplant Congress
BTLA Suppressed Acute Rejection by Regulating T Cell Receptor Downstream Signal Pathways and Cytokine Production in Renal Transplant and Contributed to Prolongation of Allograft Survival
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: The present study aimed to investigate the role of BTLA in the progress of acute rejection after kidney transplantation.*Methods: In human allograft renal transplanted…2019 American Transplant Congress
The Immunomodulatory Role of Type I Interferons in Alloimmunity
Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Despite a growing body of work on type 1 interferon (IFNAR1) signaling, there is a lack of consensus on the immunological properties of type…2019 American Transplant Congress
Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation
*Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…2019 American Transplant Congress
A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation
*Purpose: Tregs play a critical role in immune tolerance. If Tregs can be administered to patients suffering from immune disorders, most therapies employing existing immunosuppressants…2018 American Transplant Congress
Activity Nanosensors for Early and Noninvasive Detection of Acute Organ Transplant Rejection
Purpose: We engineered activity nanosensors that sense anti-allograft T cell activity in vivo to noninvasively detect the onset of acute cellular rejection from urine.Methods: Granzyme…2018 American Transplant Congress
Belatacept-Refractory CD8+CD28–CD38hi Effector/Memory T Cells Are Targeted by mTOR Inhibition Leading to a Preferential Loss of CD40L
Calcineurin inhibitors (CNIs) and corticosteroids (CSS) have substantial untoward side effects, most notably nephrotoxicity. Consequently, the FDA approved belatacept for maintenance immunosuppression. We recently completed…2018 American Transplant Congress
Recipient IFNAR1 Signaling Supports Costimulation Independent Rejection by Promoting T Cell Activation
Department of Surgery, Emory University, Atlanta, GA.
Costimulation blockade (CoB) is a promising strategy for more targeted/less toxic transplant immunosuppression which has led to the first improvement in long-term outcomes for transplant…2018 American Transplant Congress
Bone Marrow Derived Myeloid Suppressor Cell (BM-MDSCs) Prolongs the Graft Survival in Murine Heart Transplantation
Atopy(Allergy) Research Center, Juntento University, Tokyo, Japan.
Purpose: To investigate the impact of BM-MDSCs on murine heart transplantationMaterial and Methods:Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and…2018 American Transplant Congress
Lymph Node Stromal Laminins Affect Graft Survival through Regulation of CD4 T Cell Proliferation and Migration
University of Maryland, Baltimore, MD.
Background: Our prior studies demonstrated that tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511),…
- « Previous Page
- 1
- …
- 8
- 9
- 10
- 11
- 12
- …
- 20
- Next Page »