2019 American Transplant Congress
Characterization of Circulating T-cell Specific Exosomes during Acute Rejection in Murine Heart Transplantation Model
*Purpose: Exosomes are nanoparticles (30-200nm) released by many cell types. They carry nucleic acid and proteins that may reflect conditional changes in their tissue counterparts.…2019 American Transplant Congress
The mIR17-92 Cluster Promotes Costimulation Resistant Effector Memory T Cell-Mediated Alloresponses
1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC
*Purpose: CD57 expression has been shown to identify a subset of memory T cells that are resistant to CD28/B7 costimulation blockade (B7CoB). This study was…2019 American Transplant Congress
Immunobiogram, a New IVD Immunoassay to Test the Sensitivity Profile of Kidney Transplant Recipients to Immunosuppressive Drugs: Further Results from BH-Pilot Study
*Purpose: IMBG is an immunoassay developed by Biohope to measure in vitro PBMC sensitivity/resistance profile to a panel of immunosuppressive drugs (IS) in Kidney Transplant…2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…2019 American Transplant Congress
Donor-Recipient HLA Mismatched Peptides Calculated by PIRCHE Algorithm Associate with De Novo Donor-Specific Cellular and Humoral Alloreactivity and Predicts Inferior Graft Outcome
*Purpose: PIRCHE-II algorithm predicts mismatched donor-derived HLA peptides number presented on recipient HLAclass-II molecules to recipient T-cells (indirect pathway of allorecognition) and has been associated…2018 American Transplant Congress
Galangin Promotes Treg Development and Function
Introduction: FoxP3+ Treg cells are central in controlling immune responses and transplant tolerance. CD73 (ecto-5'-nucleotidase), which serves to convert AMP to adenosine, is essential for…2018 American Transplant Congress
Targeting Histone Deacetylase in Renal Tubular Epithelial Cells Inhibits Amplification of TH1 Cell-Mediated Inflammation
Inje University, Busan, Korea.
Background: Objective: More studies are focusing on renal tubular epithelial cells (RTECs) as a new target to restore inflammatory environment as clarifying their immune regulatory…2018 American Transplant Congress
Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis
University of Maryland, Baltimore, MD.
Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…2018 American Transplant Congress
Age-Specific Effects of Tacrolimus Are Associated to Specific Changes of T Cell Metabolism
Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston.
Background: Energy metabolism of immune cells has been identified as critical in driving alloimmunity. While metabolic capacities change with aging, aspects linking age, immunosuppression, and…2018 American Transplant Congress
In Vivo Imaging and Function of Renal Tertiary Lymphoid Organs
Starzl Transplantation Institute, Pittsburgh.
Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues in the setting of chronic inflammation such as organ transplantation. The function…
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