2019 American Transplant Congress
Adjunctive Therapy With Tocilizumab For Treatment Of Acute Antibody Mediated Rejection – 2 Year Experience
Washington University, St. Louis, MO
*Purpose: Reporting our center's experience in use of tocilizumab for treatment of antibody mediated rejection*Methods: We have previously reported the efficacy of Tocilizumab (TCZ), an…2019 American Transplant Congress
Unos Analysis Of Deceased Donor Renal Transplant (ddrtx) Outcomes In Sensitized Patients After Implementation Of The Kidney Allocation System (kas)
Columbia University Irving Medical Center, New York, NY
*Purpose: Introduction of KAS in 2014 prioritized access to DDRTx for highly-sensitized candidates although it was unclear whether the outcomes would be acceptable in this…2019 American Transplant Congress
Novel In Vitro Germinal Center Culture System Demonstrates More Aggressive B Cell to Plasma Blast Differentiation in Allosensitized Nonhuman Primates
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: The allogeneic humoral immune response is largely composed of T cell dependent antibody responses produced after B and T cells interact within the germinal…2019 American Transplant Congress
Memory T Follicular Helper Cell Alloresponse is Memory B Cell Independent and Inhibited by CD28 Costimulation Blockade
Emory University School of Medicine, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but reliable and durable therapeutic options to prevent or eliminate donor-specific antibodies (DSA)…2019 American Transplant Congress
Post-Transplant Cancer Following Living Donor HLA-Incompatible Kidney Transplantation
1Johns Hopkins University, Baltimore, MD, 2University of Alabama, Birmingham, AL
*Purpose: Incompatible living donor kidney transplantation (ILDKT) recipients require increased immunosuppression compared to their compatible living donor kidney transplant (CLDKT) counterparts. This continued exposure to…2018 American Transplant Congress
Clinical Outcomes of Conversion from Calcineurin Inhibitor to Belatacept-Based Immunosuppression in Highly Sensitized Kidney Transplant Recipients
Cedars Sinai Medical Center, Los Angeles.
Introduction:Efficacy of belatacept when converted from calcineurin inhibitors (CNI) in high immunologic risk patients has not been established. We examined the impact of HLA-sensitization on…2018 American Transplant Congress
Many Highly Sensitized Candidates Still Waiting for Transplant Despite the Kidney Allocation System Change: Making the Case for Incompatible Transplantation
Introduction: The rate of kidney transplantation in highly sensitized individuals has increased since the kidney allocation system (KAS) change, but it remains unclear who has…2018 American Transplant Congress
Elevated Skin Specific Non-HLA Antibodies Correlate with Acute Rejection Episodes in Clinical VCA
Introduction: Vascularized composite allotransplantation (VCA) is unique by presence of the skin in the allografts. Due to the high immunogenicity of skin and the presence…2018 American Transplant Congress
Immune Profiling in Highly Sensitized Kidney Transplant Recipients
Surgery, McGill University, Montreal, Canada.
Introduction: Highly sensitized patients (HSP) express foreign HLA antibodies and have poor graft survival due to higher incidences of graft rejection as compared to non-sensitized…2018 American Transplant Congress
Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival
Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…
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