2020 American Transplant Congress
High Intra-Patient Variability of Tacrolimus in Pediatric and Adolescent Renal Transplant Recipients is Associated with Worse Graft Outcomes
*Purpose: High intra-patient variability (IPV) in tacrolimus (TAC) levels is associated with de novo donor-specific antibodies (dnDSA) and graft loss. We examined the natural history…2020 American Transplant Congress
Outcomes of a Pre-Transplant Desensitization Protocol with Carfilzomib, Plasmapheresis, and IVIG for Broadly Sensitized Lung Transplant Candidates: A Case Series
*Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies in lung transplant candidates leads to increased wait list times and antibody-mediated rejection (AMR) post-transplant. We…2020 American Transplant Congress
Three-Year Post-Transplant Outcome of Desensitized Mechanical Circulatory Support Patients Awaiting Heart Transplantation
*Purpose: Up to 30% of durable mechanical circulatory support (MCS) patients (pts) develop panel reactive antibody (PRA) screen >= 10%. In our program, desensitization (DS)…2020 American Transplant Congress
Outcomes of CPRA 100% Deceased Donor Kidney Transplant Recipients Under the New Kidney Allocation System: A Single-Center Cohort Study
Johns Hopkins Hospital, Baltimore, MD
*Purpose: In light of changes in donor/recipient case-mix and increased cold ischemia times under KAS, there is some concern that cPRA 100% recipients might be…2020 American Transplant Congress
Virtual XM Adversely Affects Access for Highly Sensitized African Americans Awaiting Renal Transplantation
1Surgery, Baylor College of Medicine, Houston, TX, 2Surgery, UT Medical School, Houston, TX
*Purpose: Recent UNOS policy proposals have changed kidney allocation from local Designated Service Areas (DSA) to geographic distribution areas of varying widths. Since crossmatch of…2020 American Transplant Congress
Synergistic Impact of Obesity and Pre-sensitization in Kidney Transplant Recipients on the Long Term Allograft Survival
*Purpose: Obesity is emerging as important health problems worldwide. In recent years, with the development of desensitization therapy, successful kidney transplantation has been performed even…2020 American Transplant Congress
Selective Dual Co-Stimulatory Blockade of CD28/CD80-86 and PD1-PL2 with a Novel Recombinant Bi-Specific Fusion Protein (Hybri-2) Promotes Successful Humoral Desensitization in a Stringent Sensitized Rat Model
*Purpose: Humoral Alloimmune memory is a main barrier for successful kidney transplantation and is orchestrated by a compartmentalized cellular immune response driven by bone-marrow LLPCs…2020 American Transplant Congress
Clazakizumab (Anti-IL-6) Induces Foxp3+ Tregs in Highly HLA Sensitized Patients Desensitized for HLAi Transplantation (NCT03380962)
Cedars Sinai Medical Ctr, West Hollywood, CA
*Purpose: Interleukin-6 is an important inflammatory cytokine. In addition, it acts as a growth factor for B-cells, plasma cells and Th17 cells, inhibiting FoxP3+ Treg…2020 American Transplant Congress
Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized transplant recipients represent a challenging population in part due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection.…2020 American Transplant Congress
Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates Using Serial Dilutions
1Northwestern University, Chicago, IL, 2Mayo Clinic, Rochester, MN
*Purpose: Despite the new Kidney Allocation System and Kidney Paired Donation, renal allograft candidates with a >99.9% cPRA still have extremely low rates of transplantation…
American Transplant Congress abstracts