Articles tagged "Sensitization"

2019 American Transplant Congress
Transplantation of the Highly Sensitized Renal Transplant Candidate in the Post-KAS Era: Who is Left Out?
C. Schinstock, B. Smith, A. Bentall, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: Highly sensitized kidney transplant candidates are given high priority under the new kidney allocation system (KAS), but it is unclear if all sensitized candidates…
2019 American Transplant Congress
Could Intravenous Iron Strengthen The Chances Of Heart Transplantation For Patients With Left Ventricular Assist Devices?
A. Mardis¹, C. Mardis², J. Barham³, A. Poole³, S. Branham³, R. Napier⁴, J. Martin³, P. McCann⁴
¹Department of Pharmacy, Palmetto Health, Columbia, SC, ²Clinical Pharmacy and Outcomes Sciences, University of South Carolina, Columbia, SC, ³Cardiothoracic Surgery, Palmetto Health, Columbia, SC, ⁴Cardiology, Palmetto Health, Columbia, SC
*Purpose: Iron deficiency anemia (IDA) is prevalent in patients supported by left ventricular assist devices (LVADs), is associated with functional limitations, and often warrants blood…
2019 American Transplant Congress
Long-Term Outcomes of Eculizumab-Treated Positive Crossmatch Recipients: Allograft Survival, Histologic Findings, and Natural History of the Donor-Specific Antibodies
C. Schinstock, A. Bentall, S. Byron, L. Cornell, M. Everly, M. Gandhi, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: We aimed to determine long-term outcomes for eculizumab-treated, positive crossmatch (+XM) kidney transplant recipients as compared with +XM and age-matched negative crossmatch (−XM) control…
2019 American Transplant Congress
Alemtuzumab versus Antithymocyte Globulin Induction Immunosuppression in Highly Sensitized Kidney Transplant Recipients
A. Brueckner¹, E. Yanqui¹, C. Truong¹, R. Baliga², L. Bowman¹
¹Tampa General Hospital, Tampa, FL, ²Florida Kidney Physicians, Tampa, FL
*Purpose: Lymphocyte depleting agents such as rabbit anti-thymocyte globulin (rATG) and alemtuzumab are used for induction in highly sensitized (PRA ≥30%) kidney transplant recipients (KTRs).…
2019 American Transplant Congress
The Effects of Anti-BAFF Monoclonal Antibody in the HLA-A2 Sensitized Mouse Model
J. Min¹, H. Lee², B. Kim³, K. Park⁴, K. Doh³, T. Kim⁵, H. Yoon⁶, C. Yang⁷, E. Oh², B. Chung⁷
¹Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon-si, Korea, Republic of, ²Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁴Department of Molecular & Cell Biology, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁵Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁶Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea, Republic of, ⁷Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: B-cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B-cells. The aim of this study…
2019 American Transplant Congress
Outcomes of Induction Therapy with Bortezomib and High-Dose Intravenous Immunoglobulin for Kidney Transplantation with Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibodies
Y. Miyauchi, T. Noda, N. Miura, T. Kikugawa, T. Saika
Department of Urology, Ehime University, Toon, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) are known to increase the risk of antibody-mediated rejection (ABMR) and graft failure. However, effective methods…
2019 American Transplant Congress
Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation
A. Cumpelik¹, G. Varano², D. Heja¹, D. Homann³, S. Lira⁴, D. Dominguez-Sola², P. S. Heeger¹
¹Nephrology, Mount Sinai School of Medicine, New York, NY, ²Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, ³Medicine, Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY, ⁴Clinical Immunology, Mount Sinai School of Medicine, New York, NY
*Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…
2019 American Transplant Congress
Desensitization Protocols vs Kidney Paired Donation to Overcome AB0 Incompatibility and/or Donor Specific Antibodies in Living Donor Kidney Transplantation
F. Vistoli, V. Perrone, L. Gozzini, E. Kauffmann, N. Napoli, S. Iacopi, C. Lombardo, G. Amorese, U. Boggi
Pancreas and Kidney Transplantation Center, University of Pisa, Pisa, Italy
*Purpose: International guidelines indicate Living Donor Kidney Transplantation (LDKT) as the best option for ESRD patients. Immunological barriers like AB0 incompatibility (AB0i) and donor specific…
2019 American Transplant Congress
Epitop Matching Predicts Immunization in Kidney Transplant Recipients with Allograft Failure Leading to Worse Outcomes
F. Halleck¹, M. Merkel¹, P. Bach², D. Schmidt¹, M. Niemann³, N. Lachmann⁴, K. Budde¹
¹Nephrology, Charite, Berlin, Germany, ²Institute of Biometry and Clinical Epidemiology, Charite, Berlin, Germany, ³PIRCHE AG, Berlin, Germany, Berlin, Germany, ⁴Institute for Transfusion Medicine, H&I Laboratory, Charite, Berlin, Germany
*Purpose: The number of immunized patients on the waitlist is increasing worldwide. There is a lack of data about the impact of immunization after transplantation…
2019 American Transplant Congress
Intra-Operative Kinetics of Anti-HLA Antibodies in Simultaneous Liver-Kidney Transplantation
M. Kueht, P. Jindra, M. Cusick, N. Galvan, A. Rana, J. Goss
Baylor College of Medicine, Houston, TX
*Purpose: In simultaneous liver-kidney transplantation (SLKT) in highly-sensitized patients, donor specific anti-HLA antibodies (DSA) can be present prior to transplant leading to positive crossmatch, yet…

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