2019 American Transplant Congress
α -1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.
Duke Transplant Center, Durham, NC
*Purpose: Previously, we observed that sera from rhesus macaques contained preformed antibodies against wild type (WT) swine splenocytes. In the context of xenotransplantation, preformed xenoantibodies…2019 American Transplant Congress
AMD3100 and Low-Dose FK506 Prevent De Novo Donor Specific Antibody Formation and Rejection in a Sensitized Kidney Transplantation Model
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: De novo donor specific antibody (DSA) formation and antibody mediated rejection (AMR) are the main cause of allograft failure long-term. We have developed a…2019 American Transplant Congress
BCMA Expression by Alloreactive B Cells Increases during De Novo Alloantibody Responses
Comprehensive Transplant Center, Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: BCMA(TNFRSF17) belongs to tumor necrosis factor receptor superfamily. It is selectively expressed during B/plasma cell differentiation while being nearly absent on naive and memory…2019 American Transplant Congress
Should Kidney Retransplants Be Performed From Either Extended Criteria Donor Or Donation After Cardio Circulatory Death Donors?
Wake Forest Baptist Medical Center, Winston-Salem, NC
*Purpose: Donation after brain death expanded criteria donors (ECD) and donation after cardiocirculatory death (DCD) standard criteria donors (DCD/SCD) increase the donor organ pool but…2019 American Transplant Congress
Single Center Deceased Donor Renal Transplant (DDRTx) Outcomes in Sensitized Patients after Implementation of the Kidney Allocation System (KAS)
Columbia University Irving Medical Center, New York, NY
*Purpose: Introduction of KAS in 2014 prioritized access to DDRTx for highly-sensitized candidates although it was unclear whether the outcomes would be acceptable in this…2019 American Transplant Congress
Transplantation of the Highly Sensitized Renal Transplant Candidate in the Post-KAS Era: Who is Left Out?
*Purpose: Highly sensitized kidney transplant candidates are given high priority under the new kidney allocation system (KAS), but it is unclear if all sensitized candidates…2019 American Transplant Congress
Could Intravenous Iron Strengthen The Chances Of Heart Transplantation For Patients With Left Ventricular Assist Devices?
*Purpose: Iron deficiency anemia (IDA) is prevalent in patients supported by left ventricular assist devices (LVADs), is associated with functional limitations, and often warrants blood…2019 American Transplant Congress
Long-Term Outcomes of Eculizumab-Treated Positive Crossmatch Recipients: Allograft Survival, Histologic Findings, and Natural History of the Donor-Specific Antibodies
*Purpose: We aimed to determine long-term outcomes for eculizumab-treated, positive crossmatch (+XM) kidney transplant recipients as compared with +XM and age-matched negative crossmatch (−XM) control…2019 American Transplant Congress
Alemtuzumab versus Antithymocyte Globulin Induction Immunosuppression in Highly Sensitized Kidney Transplant Recipients
1Tampa General Hospital, Tampa, FL, 2Florida Kidney Physicians, Tampa, FL
*Purpose: Lymphocyte depleting agents such as rabbit anti-thymocyte globulin (rATG) and alemtuzumab are used for induction in highly sensitized (PRA ≥30%) kidney transplant recipients (KTRs).…2019 American Transplant Congress
The Effects of Anti-BAFF Monoclonal Antibody in the HLA-A2 Sensitized Mouse Model
*Purpose: B-cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B-cells. The aim of this study…
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