ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2015 American Transplant Congress

    Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 A. Gibby,1 F. Leopardi,3 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory Translant Center, Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…
  • 2015 American Transplant Congress

    MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation

    C. Burghuber,1,2 J. Kwun,1 A. Gibby,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria.

    [Background] Sensitization before transplantation and de novo alloantibodies affect a significant number of patients awaiting kidney transplantation. The type of anti-HLA antibody varies with subgroups…
  • 2015 American Transplant Congress

    Sensitization Level at Retransplant Among Non-Sensitized Pediatric Recipients of First Deceased Donor Kidney Transplants Not Affected by DR Mismatch Level

    W. Cherikh,1 A. Wilk,1 H. McGehee,1 E. Brewer.2

    1United Network for Organ Sharing, Richmond, VA; 2Baylor Coll Med & Texas Children's Hosp, Houston, TX.

    Background. Most pediatric (ped) kidney (KI) recipients (recips) received 1- or 2-DR HLA mistmached (MM) deceased donor (DD) kidneys. The degree of HLA MM between…
  • 2015 American Transplant Congress

    T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
  • 2015 American Transplant Congress

    Pancreas After Failed Islet Transplantation; a Successful Strategy to Maintain Insulin Independence

    J. Gardner,1 G. Roll,1 S. Wisel,1 J. Harbell,1 B. Hynson,1 D. Kaufman,2 A. Posselt,1 P. Stock.1

    1Department of Surgery, University of California, San Francisco, San Francisco, CA; 2Department of Surgery, University of Wisconsin, Madison, WI.

    Introduction: As islet transplantation (tx) remains an experimental and uninsured procedure, there are no established protocols to achieve insulin independence following failure of the islet…
  • 2015 American Transplant Congress

    Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization

    C. Burghuber,1,2 J. Kwun,1,3 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…
  • 2015 American Transplant Congress

    Blocking CD4 T Cell Helper Functions Improves Efficacy of ATG Treatment in Sensitized Transplant Recipients

    K. Ayasoufi, X. Wang, H. Yu, V. Gorbacheva, F. Ran, R. Fairchild, A. Valujskikh.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Antibody mediated lymphocyte depletion is used in clinical transplantation to improve graft function. While the presence of donor-reactive memory T cells is the primary rationale…
  • 2015 American Transplant Congress

    Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization

    N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    [bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
  • 2015 American Transplant Congress

    Differential Clinical Outcomes in Kidney Transplant Recipients With De Novo C1q+ and C1q- Donor Specific Antibodies

    M. Ajaimy,1 A. Colovai,2 S. Calp,1 J. Lindower,1 M. Melamed,3 E. Akalin.1

    1Transplantation, Einstein/Montefiore Transplant Center, Bronx; 2Tissue Typing Laboratory, Einstein/Montefiore Transplant Center, Bronx; 3General Nephrology, Einstein/Montefiore Teaching Hospital, Bronx.

    Background: We investigated the prevalence and clinical significance of C1q binding versus non-C1q binding de novo DSA in kidney transplant recipients.Methods: The study group included…
  • 2015 American Transplant Congress

    The Use of Bortezomib for Desensitization in ABO Incompatible and Positive Crossmatch Kidney Transplant

    J. Benken,1 S. Akkina,2 E. Benedetti.3

    1Pharmacy Practice, Univ. of IL-Chicago, Chicago, IL; 2Dept. of Medicine, Nephrology, Univ. of IL-Chicago, Chicago, IL; 3Dept. of Surgery, Univ. of IL-Chicago, Chicago, IL.

    Introduction:ABO incompatible (ABOi) and positive crossmatch (PXM) living donor kidney transplantation is a life-saving alternative to dialysis. A variety of protocols exist utilizing plasmapheresis (PP)…
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