2015 American Transplant Congress
Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation
[Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…2015 American Transplant Congress
MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation
1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria.
[Background] Sensitization before transplantation and de novo alloantibodies affect a significant number of patients awaiting kidney transplantation. The type of anti-HLA antibody varies with subgroups…2015 American Transplant Congress
Sensitization Level at Retransplant Among Non-Sensitized Pediatric Recipients of First Deceased Donor Kidney Transplants Not Affected by DR Mismatch Level
Background. Most pediatric (ped) kidney (KI) recipients (recips) received 1- or 2-DR HLA mistmached (MM) deceased donor (DD) kidneys. The degree of HLA MM between…2015 American Transplant Congress
T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques
[Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…2015 American Transplant Congress
Pancreas After Failed Islet Transplantation; a Successful Strategy to Maintain Insulin Independence
Introduction: As islet transplantation (tx) remains an experimental and uninsured procedure, there are no established protocols to achieve insulin independence following failure of the islet…2015 American Transplant Congress
Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization
[Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…2015 American Transplant Congress
Blocking CD4 T Cell Helper Functions Improves Efficacy of ATG Treatment in Sensitized Transplant Recipients
Immunology, Cleveland Clinic, Cleveland, OH.
Antibody mediated lymphocyte depletion is used in clinical transplantation to improve graft function. While the presence of donor-reactive memory T cells is the primary rationale…2015 American Transplant Congress
Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
[bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…2015 American Transplant Congress
Differential Clinical Outcomes in Kidney Transplant Recipients With De Novo C1q+ and C1q- Donor Specific Antibodies
Background: We investigated the prevalence and clinical significance of C1q binding versus non-C1q binding de novo DSA in kidney transplant recipients.Methods: The study group included…2015 American Transplant Congress
The Use of Bortezomib for Desensitization in ABO Incompatible and Positive Crossmatch Kidney Transplant
Introduction:ABO incompatible (ABOi) and positive crossmatch (PXM) living donor kidney transplantation is a life-saving alternative to dialysis. A variety of protocols exist utilizing plasmapheresis (PP)…
American Transplant Congress abstracts