Articles tagged "Sensitization"

2016 American Transplant Congress
Early Impact of the New Kidney Allocation System (KAS) in Highly Sensitized Patients.
D. Mompoint-Williams, R. Gaston, G. Jeremy, J. Locke, V. Kumar.
University of Alabama at Birmingham, Birmingham, AL.
PurposeHighly sensitized (HS) patients, defined as a PRA of 99-100% are awarded additional priority points in the new KAS instituted December 2014. We evaluated the…
2016 American Transplant Congress
99% and 100% CPRA Patients Since KAS: A Substantial Increase in Transplants with Strong Evidence of a Bolus Effect.
A. Kucheryavaya,¹ M. Aeder,² N. Turgeon,³ D. Klassen,¹ D. Stewart.¹
¹UNOS, Richmond, VA; ²Univ Hosp Case Med Ctr, Cleveland, OH; ³Emory Univ Hosp, Atlanta, GA.
Background: The Kidney Allocation System (KAS), implemented on 12/4/14, increased allocation priority for candidates with CPRA of 99-100%. Analyses performed on behalf of the OPTN…
2016 American Transplant Congress
Optimizing CPRAs for Sensitized Kidney Waitlist Candidates: The Devil Is in the KAS Details.
J. Houp,¹ R. Vega,¹ B. Lonze,² N. Desai,² R. Montgomery,² A. Jackson.¹
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD.
The new kidney allocation system (KAS) has increased transplant rates for highly sensitized candidates. We hypothesized that increasing unacceptable antigens to transition candidates from 80-98%…
2015 American Transplant Congress
Left Ventricular Assist Device–Associated Allosensitization — Clinical Implications
B.-S. Ko, C. Willis, S. Drakos, D. Hurst, A. Kfoury, G. Snow, J. Delgado, E. Hammond, C. Selzman, R. Alharethi, S. McKellar, J. Nativi-Nicolau, E. Gilbert, P. Revelo, D. Miller, B. Reid, J. Fang, D. Eckles, J. Stehlik.
U.T.A.H. Cardiac Transplant Program, Salt Lake City, UT.
Purpose: Allosensitization has been recognized as a prognostic marker of worse outcome after transplant. It is unclear, however, whether sensitization events that take place shortly…
2015 American Transplant Congress
Are DQA Antibodies Real?
J. Jones, D. Lucas, M. Leffell, A. Zachary.
Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…
2015 American Transplant Congress
Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation
C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ A. Gibby,¹ F. Leopardi,³ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.^1,3
¹Emory Translant Center, Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…
2015 American Transplant Congress
MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation
C. Burghuber,^1,2 J. Kwun,¹ A. Gibby,¹ N. Iwakoshi,¹ S. Knechtle.¹
¹Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria.
[Background] Sensitization before transplantation and de novo alloantibodies affect a significant number of patients awaiting kidney transplantation. The type of anti-HLA antibody varies with subgroups…
2015 American Transplant Congress
Sensitization Level at Retransplant Among Non-Sensitized Pediatric Recipients of First Deceased Donor Kidney Transplants Not Affected by DR Mismatch Level
W. Cherikh,¹ A. Wilk,¹ H. McGehee,¹ E. Brewer.²
¹United Network for Organ Sharing, Richmond, VA; ²Baylor Coll Med & Texas Children's Hosp, Houston, TX.
Background. Most pediatric (ped) kidney (KI) recipients (recips) received 1- or 2-DR HLA mistmached (MM) deceased donor (DD) kidneys. The degree of HLA MM between…
2015 American Transplant Congress
T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques
C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.¹
¹Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
2015 American Transplant Congress
Pancreas After Failed Islet Transplantation; a Successful Strategy to Maintain Insulin Independence
J. Gardner,¹ G. Roll,¹ S. Wisel,¹ J. Harbell,¹ B. Hynson,¹ D. Kaufman,² A. Posselt,¹ P. Stock.¹
¹Department of Surgery, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, University of Wisconsin, Madison, WI.
Introduction: As islet transplantation (tx) remains an experimental and uninsured procedure, there are no established protocols to achieve insulin independence following failure of the islet…