ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2016 American Transplant Congress

    Characteristics Independently Associated with Kidney Candidates Having CPRA of 99-100%.

    A. Kucheryavaya, D. Klassen, D. Stewart.

    UNOS, Richmond, VA.

    Background: The new Kidney Allocation System (KAS) implemented on 12/4/14 included an increased allocation priority for candidates with CPRA 99-100%. On 11/30/14, just days prior…
  • 2016 American Transplant Congress

    Pregnancy Excludes Women from Successful Living Donor Transplantation.

    P. Porrett,1 B. Bromberger,2 S. Hashmi,1 A. Morrison,1 D. Sawinski.3

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Surgery, Columbia University, New York, NY; 3Medicine, University of Pennsylvania, Philadelphia, PA.

    INTRODUCTION Pregnancy-induced sensitization (PIS) is a barrier to the transplantation of women and contributes significantly to gender disparity in transplantation. We hypothesized that this barrier…
  • 2016 American Transplant Congress

    Bone Allograft: An Unusual Cause of Sensitization.

    J. Bloch,1 V. Elsermans,2 F. Provôt,1 A. Lionet,1 L. Wajbrot-Houzé,3 C. Noel,1 M. Hazzan.1

    1Service de Néphologie et Transplantation, CHRU, Hopital Claude Huriez, Lille, France; 2Institut d'Immunologie, CHRU, Centre de Biologie et Pathologie, Lille, France; 3Service de Néphrologie, Centre Hospitalier de Béthune, Béthune, France.

    We report the case of a 33 year-old female patient who started hemodialysis in 2009 because of end stage renal disease of unknown etiology. When…
  • 2016 American Transplant Congress

    Activation of Alloreactive T Cells by Allogeneic Exosomes and Cells Cross-Dressed with Allogeneic MHC Molecules.

    M. Babiker-Mohamed, J. Marino, P. Crosby, G. Benichou.

    Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital & Harvard Medical School, Boston, MA.

    Our recent studies have documented the presence of high numbers of recipient antigen presenting cells (APCs) displaying donor MHC molecules (cross-dressed) on their surface after…
  • 2016 American Transplant Congress

    Limiting Helper Functions of CD4 T Cells Improves Efficacy of Induction Therapy without Compromising Responses to Third Party Antigens.

    K. Ayasoufi, V. Gorbacheva, F. Ran, A. Valujskikh.

    Cleveland Clinic, Cleveland.

    Antibody mediated lymphocyte depletion is commonly used in clinical transplantation. However, memory T cells undermine the efficacy of lymphoablative induction therapies in sensitized transplant recipients.…
  • 2016 American Transplant Congress

    Frequency and Utility of Donor-Specific Antibody Testing in Simultaneous Liver Kidney Transplant.

    A. Morrison,1 D. Sawinski,2 M. Kamoun,3 P. Porrett.1

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Medicine, University of Pennsylvania, Philadelphia, PA; 3Pathology, University of Pennsylvania, Philadelphia, PA.

    Introduction: The risk of antibody mediated rejection (AMR) in simultaneous liver kidney (SLK) recipients is thought to be lower than in kidney alone patients due…
  • 2016 American Transplant Congress

    Transplanting the Extremely Sensitized Patient: The University of Wisconsin Experience with the New Kidney Allocation System.

    E. Grodstein, R. Bennett, J. Anderson, G. Press, A. Djamali, D. Kaufman, R. Redfield.

    Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, WI.

    Background: The new UNOS kidney allocation system (KAS) prioritizes the transplant of highly sensitized patients with a calculated Panel Reactive Antibody (cPRA) ≥80 and extremely…
  • 2016 American Transplant Congress

    Anti-HLA Antibodies in Allogeneic and Autologous Hematopoietic Stem Cell Transplantation.

    A. Bertocchi, L. Requiao-Moura, M. Torres, E. Tonato, M. Durao Junior, A. de Matos, N. Hamershclak, A. Pacheco-Silva.

    Kidney Transplantation, Hematology, Histocompatibility Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

    Introduction: Anti-HLA antibodies have been associated with graft rejection in solid organ and hematopoietic stem cell transplantation (HSCT). The aim of this study was describe…
  • 2016 American Transplant Congress

    Do All cPRA 100% Candidates Have Equal Access to Organ Allocation?

    H. Gebel,1,2 S. Gustafson,1 D. Segev,1,3 B. Kasiske,1 A. Israni.1

    1Scientific Registry of Transplant Recipients, Minneapolis; 2Pathology, Emory University Hospital, Atlanta; 3Surgery, Johns Hopkins, Baltimore.

    Renal transplant candidates with cPRA values of 98%, 99%, and 100% received local, regional, and national priority, respectively, for deceased donor kidneys with the new…
  • 2016 American Transplant Congress

    Impact of the New Kidney Allocation System on Highly Sensitized Patients: Single Center Report.

    A. Mattiazzi,1 W. Kupin,1 D. Roth,1 L. Chen,2 G. Burke,2 G. Ciancio,2 P. Ruiz,2 R. Vianna,2 G. Guerra.1

    1Department of Medicine, Division of Nephrology, Miami Transplant Institute, Miami, FL; 2Department of Surgery, Miami Transplant Institute, Miami, FL.

    Background: Highly sensitized patients (HSP) with calculated Panel Reactive Antibody (cPRA) >80% are known to have extensive waiting time on UNOS list. The new kidney…
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