Articles tagged "Sensitization"

2016 American Transplant Congress
Do All cPRA 100% Candidates Have Equal Access to Organ Allocation?
H. Gebel,^1,2 S. Gustafson,¹ D. Segev,^1,3 B. Kasiske,¹ A. Israni.¹
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Pathology, Emory University Hospital, Atlanta; ³Surgery, Johns Hopkins, Baltimore.
Renal transplant candidates with cPRA values of 98%, 99%, and 100% received local, regional, and national priority, respectively, for deceased donor kidneys with the new…
2016 American Transplant Congress
Impact of the New Kidney Allocation System on Highly Sensitized Patients: Single Center Report.
A. Mattiazzi,¹ W. Kupin,¹ D. Roth,¹ L. Chen,² G. Burke,² G. Ciancio,² P. Ruiz,² R. Vianna,² G. Guerra.¹
¹Department of Medicine, Division of Nephrology, Miami Transplant Institute, Miami, FL; ²Department of Surgery, Miami Transplant Institute, Miami, FL.
Background: Highly sensitized patients (HSP) with calculated Panel Reactive Antibody (cPRA) >80% are known to have extensive waiting time on UNOS list. The new kidney…
2016 American Transplant Congress
Early Impact of the New Kidney Allocation System (KAS) in Highly Sensitized Patients.
D. Mompoint-Williams, R. Gaston, G. Jeremy, J. Locke, V. Kumar.
University of Alabama at Birmingham, Birmingham, AL.
PurposeHighly sensitized (HS) patients, defined as a PRA of 99-100% are awarded additional priority points in the new KAS instituted December 2014. We evaluated the…
2016 American Transplant Congress
99% and 100% CPRA Patients Since KAS: A Substantial Increase in Transplants with Strong Evidence of a Bolus Effect.
A. Kucheryavaya,¹ M. Aeder,² N. Turgeon,³ D. Klassen,¹ D. Stewart.¹
¹UNOS, Richmond, VA; ²Univ Hosp Case Med Ctr, Cleveland, OH; ³Emory Univ Hosp, Atlanta, GA.
Background: The Kidney Allocation System (KAS), implemented on 12/4/14, increased allocation priority for candidates with CPRA of 99-100%. Analyses performed on behalf of the OPTN…
2016 American Transplant Congress
Optimizing CPRAs for Sensitized Kidney Waitlist Candidates: The Devil Is in the KAS Details.
J. Houp,¹ R. Vega,¹ B. Lonze,² N. Desai,² R. Montgomery,² A. Jackson.¹
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD.
The new kidney allocation system (KAS) has increased transplant rates for highly sensitized candidates. We hypothesized that increasing unacceptable antigens to transition candidates from 80-98%…
2016 American Transplant Congress
Blindspots in HLA Antibody Testing: Recognition Is First Step to Nirvana.
A. Kher, P. Dorwal, V. Kher.
Medanta-The Medicity, Gurgaon, Haryana, India.
This study was conducted to assess population frequency of alleles missing from single antigen bead (SAB) panels & frequency of allelic antibodies (Abs).Methods: All positive…
2016 American Transplant Congress
Impact of Angiotensin II Type I Receptor Antibody Positivity in Highly-HLA Sensitized (HS) Patients Transplanted After Desensitization (DES).
A. Vo,¹ C. Boutsicaris,¹ X. Zhang,² N. Reinsmoen,² J. Choi,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²HLA Laboratory, Cedars-Sinai Medical Center, LA, CA.
Introduction: Angiotensin II type I receptor antibody (AT1R Ab) is a target for non-HLA antibodies. AT1R ab exert direct effects on endothelial and vascular smooth…
2016 American Transplant Congress
Accumulation of Highly Sensitized Patients in a KPD Registry.
S. Stepkowski, B. Mierzejewska, D. Bekbolsynow, M. Rees.
University of Toledo, Toledo, OH.
Objectives: We analyzed sensitization against HLA among patients in a kidney paired donation (KPD) registry. In particular, three groups of patients were included: 1) all…
2016 American Transplant Congress
Type of Sensitization Does Not Impact Kidney Graft Outcome in Weakly Sensitized Patients.
A. Morrison,¹ D. Sawinski,² M. Lim,² M. Levine,¹ M. Kamoun,³ P. Porrett.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: The impact of low level sensitization on kidney transplant (KTx) outcomes is unclear. While limited data suggest that KTx outcomes are comparable between weakly…
2016 American Transplant Congress
The Effect of Donor-Recipient Relationship on the Immunologic Outcome in Living Kidney Transplantation.
D. Khadzhynov, F. Halleck, L. Lehner, M. Duerr, J. Waiser, K. Budde, O. Staeck.
Nephrology, Charite Campus Mitte, Berlin, Germany.
Background. Presensitization and degree of HLA-matching influences immunologic outcome and kidney graft survival. Thus the donor-recipient relationship may influence incidence of immunologic events and outcome…