Articles tagged "Safety"

2015 American Transplant Congress
Interim Safety Experience in Transplant Patients Treated With Belatacept (Nulojix) in the Post-Approval Setting
T. Kou, J. Braga, S. Sibabrata, J. Preston, M. Harler, A. Gomez.
Bristol-Myers Squibb Company, Princeton, NJ.
Purpose: Belatacept is a selective T-cell costimulation blocker indicated for prophylaxis of organ rejection in adult patients receiving a kidney transplant in combination with basiliximab…
2015 American Transplant Congress
Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients
J. Leventhal,¹ A. LeFever,² A. Skaro,¹ L. Gallon,¹ J. Mathew,¹ D. Stare,¹ I. Konieczna,¹ J. He,¹ G. Johnson.³
¹Northwestern University, Chicago; ²Northwestern Memorial Hospital, Chicago; ³TRACT Therapeutics Inc., Chicago.
Therapeutic cell transfer using regulatory T cells (Tregs) in transplant recipients may reduce the need for drug based immunosuppression (IS) and improve long term graft…
2015 American Transplant Congress
Trends in Transplant Patient Safety Situation Reporting
T. Daly,¹ H. Neil,² D. Stewart,² S. Tlusty,² A. Harper,² D. Marshman,³ M. Green.⁴
¹NY-Presbyterian Hosp., New York, NY; ²UNOS, Richmond, VA; ³LifeNet Health, Roanoke, VA; ⁴Children's Hosp. of Pittsburgh, Pittsburgh, PA.
Background: The OPTN Operations & Safety Committee is charged with reviewing aggregated, de-identified safety situation data reported through both the UNet Improving Patient Safety (IPS)…
2015 American Transplant Congress
Role of Universal Decolonization After Kidney Transplant: A Pilot Study
D. Lee,¹ G. Malat,² N. Law,¹ A. Sharma,¹ T. Bias,¹ K. Ranganna,¹ A. Doyle.¹
¹Department of Medicine, Drexel University, College of Medicine, Philadelphia, PA; ²Department of Surgery, Drexel University, College of Medicine, Philadelphia, PA.
IntroductionInfection is a common cause of morbidity and mortality after kidney transplantation. Despite careful pre-transplantation screening of donors and recipients, vaccination, prophylaxis, and antimicrobial use,…
2015 American Transplant Congress
Establishment of Diabetes Modeling in Common Marmoset
W. Yuan,¹ S. Fukuda,¹ T. Inoue,² D. Chujo,¹ H. Okochi,¹ E. Sasaki,² M. Shimoda.¹
¹National Center for Global Health and Medicine, Tokyo, Japan; ²Central Institute for Experimental Animals, Kawasaki, Japan.
Background:Diabetic nonhuman primates (NHPs) are considered as the good models for both diabetes mellitus research and islet transplantation research safely into clinical applications. However, there…
2015 American Transplant Congress
Systematic Medical Record Review to Identify Safety Risks in Living Liver Donors
B. Platt,⁵ D. Woods,⁵ R. Fisher,² J. Guarrera,³ E. Pomfret,⁴ M. Simpson,⁴ A. Daud,¹ T. Curtis,⁵ E. Reyes,⁵ E. Wymore,⁵ A. Skaro,¹ D. Ladner.¹
¹Northwestern University, Chicago, IL; ²Virginia Commonwealth University, Richmond, VA; ³Columbia University, New York, NY; ⁴Lahey Clinic, Boston, MA; ⁵CHS, Northwestern University, Chicago, IL.
BACKGROUNDPrevention of adverse events (AEs) is important in Living Donor Liver Transplantation (LDLT), as these are healthy volunteers who undergo a major procedure with no…
2015 American Transplant Congress
Somatostatin (Eumedica®) Infusion Allows Modulating Graft Flows and Gradients in Liver Transplantation. Results of a Randomized, Double Blind, Placebo Controlled Trial
R. Troisi,¹ A. Croo,¹ E. Codarin,³ E. De Wolf,¹ J. Van Limmen,⁴ G. Antoniali,³ B. Heyse,⁴ L. De Baerdemaeker,⁴ I. Colle,⁵ G. Tell,³ M. Sainz-Barriga.^1,2
¹General Hepatobiliary Surgery Liver Transplantation Service, Ghent University Hospital Medical School, Ghent, Belgium; ²Digestive Surgery & Liver Transplantation, University of Tours, Tours, France; ³Medical & Biological Sciences, University of Udine, Udine, Italy; ⁴Anesthesiology, Ghent University Hospital Medical School, Ghent, Belgium; ⁵Gastroenterology, Ghent University Hospital Medical School, Ghent, Belgium.
Background: Somatostatin (SST) infusion decrease portal pressure in acute variceal bleeding in cirrhotic patients. Despite liver transplantation (LTx), recipients with portal hypertension (PHT) display different…
2015 American Transplant Congress
Belatacept in a Community Hospital Adult Kidney Transplant Program
D. Nikolaenko, Q. Chaudhry, H. Smith, C. Shadur.
Iowa Methodist Medical Center, Des Moines, IA.
PURPOSE:This is a retrospective look (08/2011-11/2014) on data collected from patients transplanted at Iowa Methodist Transplant Center.METHODS:All patients were EBV positive. They were induced with…
2015 American Transplant Congress
Belatacept Treatment Through Home Infusion as a Safe and Reasonable Alternative to Intitution-Based Treatment: A Retrospective Analysis of Medical Records
T. Kou,¹ A. Deshmukh,¹ J. Preston,¹ A. Gomez,¹ S. Rafanelli,² K. Calderon.¹
¹Bristol-Myers Squibb Company, Princeton, NJ; ²BiologicTx, Totowa, NJ.
Purpose: Belatacept is a selective T-cell costimulation blocker indicated for prophylaxis of organ rejection in adult patients receiving a kidney transplant in combination with basiliximab…