Articles tagged "Renal ischemia"

2019 American Transplant Congress
Endovascular Repair Of Abdominal Aortic Aneurysms In Kidney Transplant Recipients
S. Kwon¹, D. Jung¹, Y. Kim¹, S. Park², S. Yoon²
¹Department of Vascular and Transplant Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Department of Vascular and Transplant Surgery, The Catholic Universtiy of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of
*Purpose: The possibility to diagnosis abdominal aortic aneurysm (AAA) in patients who underwent kidney transplantation (KT) is increasing. Immunosuppressive agents may effect on AAA progression.…
2019 American Transplant Congress
Human Urine-Derived Stem Cells Protect against Renal Ischemia Reperfusion Injury via Releasing Exosomal miR-146a-5p Which Targets IRAK1 in a Rat Model
X. Li, Z. Bi, Q. Su, H. Huang, L. Liu, C. Wang
Organ Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Severe ischemia reperfusion injury (IRI) causes delayed graft function and impaires renal allograft survival. Human urine-derived stem cells (hUSCs) is a new source of…
2019 American Transplant Congress
C1 Esterase Inhibitor (C1INH) Treatment at Kidney Transplant Improves Long-Term Outcomes in Patients at Risk for Ischemia/Reperfusion Injury & Delayed Graft Function
S. Jordan¹, E. Huang², N. Ammerman¹, J. Choi¹, O. Aubert³, S. Kumar¹, A. Loupy⁴, A. Peng¹, I. Kim¹, R. Najjar¹, D. Puliyanda¹, T. Brennan¹, S. Sethi¹, A. Vo¹
¹Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ³Biostatistics Department, Paris Translational Research Center for Organ Transplantation, Paris, France, ⁴Biostatistics, Paris Translational Research Center for Organ Transplantation, Paris, France
*Purpose: Delayed graft function(DGF) is defined as need for dialysis early post-transplant. DGF is related to ischemia reperfusion injury (IRI) that diminishes allograft function and…
2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
D. Aufhauser, D. Murken,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2018 American Transplant Congress
Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model
L. Liu, X. Li, Q. Su, Z. Bi, H. Huang, C. Wang.
Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, New York, NY, China.
Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2017 American Transplant Congress
Evaluation of Outcomes in Renal Transplantation Using Machine Perfusion for the Preservation of Kidneys from Expanded Criteria Donor.
E. Savoye, M. Macher, Kidney Working Group, C. Legeai, C. Antoine.
Agence de la Biomedecine, Saint Denis La Plaine, France
Introduction:The shortage of kidney grafts led to retrieve organs from old donors with one or more co-morbidities, considered as “expanded criteria donors” (ECD). In France,…
2017 American Transplant Congress
The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.
G. Weber,¹ N. Ambrosi,² F. Caro,² S. Beltramino,¹ A. Fernández,¹ I. Cabrera,¹ G. Hilchenbach,¹ D. Fernandez,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; ²CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; ³Fundación GADOR, Buenos Aires, Argentina
A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…

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