Articles tagged "Renal ischemia"

2019 American Transplant Congress
Histone Deacetylase-8 (HDAC8) Inhibition is Protective in a Murine Model of Renal Ischemia Reperfusion Injury (IRI)
P. T. Hernandez¹, S. J. Concors¹, D. D. Aufhauser¹, L. Krumeich¹, Z. Wang¹, G. Ge¹, A. Beeler², M. Levine¹, W. Hancock³
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Chemistry, Boston University, Boston, MA, ³Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: IRI is a major source of morbidity after renal transplantation, contributing to poor transplant outcomes and decreased graft survival. Histone deacetylases (HDACs) are enzymes…
2019 American Transplant Congress
Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors
M. Doshi¹, I. Hall², S. Mohan³, C. Liu⁴, H. Philbrook⁴, P. Reese⁵, S. Mansour⁶, F. Weng⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, T. Muthukumar¹¹, B. Schroeppel¹², P. Singh¹³, C. Parikh⁴
¹University of Michigan, Ann Arbor, MI, ²University of Utah, Salt Lake City, UT, ³Columbia, New York, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Yale University, New Haven, CT, ⁷St. Barnabas, Livingston, NJ, ⁸Mount Sinai, New York, NY, ⁹University of Maryland, Baltimore, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Cornell, New York, NY, ¹²University of Ulm, Ulm, Germany, ¹³Jefferson, Philadelphia, PA
*Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…
2019 American Transplant Congress
Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury
J. Kim¹, J. Park², K. Yoo², J. Moon¹, J. Jeong¹, C. Lee³, Y. Kim¹, S. Yang⁴
¹Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Dongguk University College of Medicine, Gyeonggi-do, Korea, Republic of, ³Cheju Halla General Hospital, Cheju, Jeju-do, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University, Seoul, Korea, Republic of
*Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…
2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
D. Aufhauser, D. Murken,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2018 American Transplant Congress
Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model
L. Liu, X. Li, Q. Su, Z. Bi, H. Huang, C. Wang.
Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, New York, NY, China.
Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…
2017 American Transplant Congress
Nafamostat Mesilate Ameliorates Ischemia-Reperfusion Renal Injury via Anti-Apoptotic Mechanism.
D. Choi,¹ J. Jeong,² H. Bae,¹ Y. Ham,¹ K. Lee,¹ K. Na.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: It has been reported that nafamostat mesilate inhibits inflammatory injury via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is…
2017 American Transplant Congress
Postoperative Serum Lactate Dehydrogenase Is a "Troponin-Like" Marker of Renal Transplant Distress.
R. Steiner, J. Halldorson.
UCSD Center for Transplantation, University of California at San Diego, San Diego, CA
Lactate dehydrogenase (LDH) is plentiful in renal tubular cells and is released during tubular injury or death. It increases for several days to 1500-2000 U/L…
2017 American Transplant Congress
Living Kidney Transplant: The Influence of Intraoperative Hemodynamics on Delayed Graft Function.
R. Schutt,¹ J. Case,¹ B. Barrick,¹ A. Toll,² C. Marsh.¹
¹Scripps Center for Organ and Cell Transplantation, Scripps Green Hospital, La Jolla, CA; ²Research Department and Analytics, UNOS, Richmond, VA
Despite advantages of living donor kidneys, intraoperative insults may subject these kidneys to poor outcomes. Therefore, we investigated whether intraoperative fluid volumes and hemodynamics in…
2017 American Transplant Congress
Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.
M. Thomas, G. Tardif, A. Melanger, P. Berna.
Balmes Transplantation, Marseille, France
Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…

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