Articles tagged "Renal ischemia"

2015 American Transplant Congress
Chemokine Receptor 5 Blockade Modulates Inflammation and Immunity in Renal Ischemic Reperfusion Injury
K. Yoo,¹ S. Han,¹ J. Park,¹ E. Bae,¹ J. Park,¹ J. An,¹ J. Lee,¹ D. Kim,¹ Y. Kim,^1,2 S. Yang.²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea.
Macrophages, which exhibit great pliability, are important components of renal ischemic reperfusion injury (IRI) and are closely correlated with loss of renal function. Chemokine Receptor…
2015 American Transplant Congress
Distinct Role of Complement Receptors C5L2 and C5aR in Acute Kidney Injury and Renal Fibrosis
A. Thorenz,¹ R. Chen,¹ K. Hüper,³ B. Hensen,³ C. Klemann,⁵ M. Meier,⁴ A. Klos,² F. Güler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Microbiology, Medical School, Hannover, Germany; ³Radiology, Medical School, Hannover, Germany; ⁴Imaging Center, Medical School, Hannover, Germany; ⁵Pediatric Surgery, Medical School, Hannover, Germany.
ObjectiveAcute kidney injury (AKI) is a relevant complication in solid organ transplantation with incidence rates of ∼50-75 % after lung- and heart transplantation. In addition,…
2015 American Transplant Congress
In Pre-Implantation Biopsies Expression of Micro RNAs Is Not a Good Surrogate for Established mRNA Markers of Kidney Injury
K. Famulski,¹ S. Niederhaus,² J. Reeve,¹ J. Bromberg,² P. Halloran.¹
¹University of Alberta, Edmonton, Canada; ²University of Marlyland, Baltimore.
Kidneys from brain dead donors>50 years old are often discarded based on conventional (clinical and histologic) criteria, despite their poor predictive value for subsequent performance…
2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
B. Yang,¹ K. Hamelin,¹ L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ N. Patey,² M.-J. Hébert.¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montréal, Canada; ²Department of Pathology, CHU Ste-Justine Université de Montréal, Montréal, Canada.
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…
2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
M. Kaisar,^1,2 H. Huang,^1,2 Z. Akhtar,¹ H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, University of Oxford, Oxford, United Kingdom; ³Surgical Research Laboratory, UMC, Groningen, Netherlands.
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…