Articles tagged "Renal injury"

2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, ³Medical Science, Chungnam National University, Daejeon, Korea, Republic of
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
D. A. Cheung¹, J. Garcia¹, T. Beduschi², A. H. Langshaw¹, K. L. Arheart³, I. A. Gonzalez⁴
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL, ³Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, ⁴Pediatric Infectious Diseases and Immunology, University of Miami, Miami, FL
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…
2018 American Transplant Congress
Comparison of Temperatures for Optimal Preservation of Donor Kidneys during Oxygenated Pulsatile Perfusion
R. Bhattacharjee,¹ M. Richard-Mohamed,² A. Ruthirakanthan,³ R. Mayer,² S. Luke,³ H. Sharma,² M. TunAbraham,² B. Alharbi,² A. Haig,² P. Luke.^1,2,3
¹Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Western University, Canada, London, ON, Canada.
Background. The current methods of preserving DCD renal allografts in either static cold solution or hypothermic pulsatile perfusion are unable to adequately protect the kidney…
2018 American Transplant Congress
The Prognostic Implications of Renal Function Recovery and Delayed Graft Function in Kidney Transplantation
S. Sandal, M. Cantarovich, A. Ramankumar, N. Saberi, C. Saw, D. Baran, P. Chaudhury, S. Paraskevas, J. Tchervenkov.
MUHC, Montreal, Canada.
Introduction: Lack of renal function recovery (RFR), 90 days after acute kidney injury (AKI) is a contributor to inferior renal outcomes and mortality. Ischemia and…
2018 American Transplant Congress
Etiologies and Long-Term Outcomes of Acute Kidney Injury in Older Kidney Transplant Recipients
R. Rodriguez, P. Amechi, V. Rao, D. Taber, M. Posadas Salas.
Medical University of South Carolina, Charleston, SC.
Older kidney transplant recipients face challenges of post-transplant complications related to frailty and comorbidity burden. They are particularly vulnerable to acute kidney injury (AKI) due…
2018 American Transplant Congress
Death-Censored Graft Failure (DCGF) Post Kidney Transplant (KTx) is Usually the Result of Rapid Loss of Function after Periods of Stability
R. Gaston,¹ L. Hunsicker,² A. Fieberg,³ A. Matas,³ The DeKaf Consortium.
¹CTI Clinical Trial & Consulting, Covington, KY; ²Int. Med., U Iowa, Iowa City, IA; ³Biostatistics and Surgery, U Minnesota, Minneapolis, MN.
Late graft dysfunction leading to clinically indicated transplant biopsy (KTxBx) is a better predictor of subsequent DCGF than baseline data and early post-transplant events (Gaston…
2018 American Transplant Congress
The Role of Donor-Derived Cell-Free DNA in Identification of Injury in Kidney Allografts with Antibody-Mediated Rejection and De Novo DSA
H. Zhang,¹ L. Liu,¹ C. Zheng,² X. Li,¹ Q. Fu,¹ J. Li,¹ Q. Su,¹ H. Huang,¹ M. Ye,² C. Wang.¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; ²BGI-Guangzhou Medical Laboratory, BGI-Shenzhen, Guangzhou, China.
Objectives: To evaluate the capacity of donor-derived cell-free DNA (dd-cfDNA) in the identification of injury in kidney allografts with antibody-mediated rejection and de novo DSA.Methods:…
2018 American Transplant Congress
Peri-Operative Hemoglobin, Blood Transfusion and Delayed Graft Function in Kidney Transplant Recipients
S. MacIsaac, A. Ramankumar, C. Saw, V. Naessens, M. Cantarovich, D. Baran, S. Paraskevas, J. Tchervenkov, P. Chaudhury, S. Sandal.
MUHC, Montreal, Canada.
Background: Studies in the non-kidney transplant (KT) literature support an absolute hemoglobin concentration (Hb) threshold of 70 g/L for transfusion, unless otherwise indicated. Some reports…
2018 American Transplant Congress
Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients
M. Pearl,¹ J. Grotts,¹ M. Rossetti,¹ Q. Zhang,¹ P. Weng,¹ E. Reed,¹ E. Tsai Chambers.²
¹University of California, Los Angeles, Los Angeles, CA; ²Duke University, Durham, NC.
Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…
2018 American Transplant Congress
Clinical Analysis of Impact of Intraoperative Hepatic Blood Inflow on Acute Kidney Injury Following Allogeneic Liver Transplantation
J. Zhang, Q. Liu, X. Li, Y. Meng, L. Yang, C. Zhang, N. Sun, A. Jiao, J. Lin.
Hepatobiliary Surgery Department and Unit of Organ Transplantation, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Background Acute kidney injury (AKI) is a major and severe complication following allogeneic liver transplantation and is associated with increased postoperative morbidity and mortality. With…

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