Articles tagged "Renal injury"

2019 American Transplant Congress
New Reactive Oxygen Species Scavenger Prevents Injury in Ischemia-Reperfusion Injury Model
N. Bath, W. Fahl, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Despite the success of preservation solutions, Ischemia-Reperfusion (IR) injury remains a significant problem for all solid organ transplants. As a result, an important, unmet…
2019 American Transplant Congress
Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs
A. Longchamp¹, R. P. Meier², N. Colucci³, A. Balaphas³, L. Orci³, A. Nastasi³, G. Longchamp¹, S. Moll⁴, A. Klauser⁵, F. Lazeyras⁵, M. Pascual⁶, J. Corpataux⁷, L. Bühler⁸
¹Department of Vascular Surgery, CHUV, Lausannne, Switzerland, ²Department of Surgery, University of California San Francisco, San Francisco, CA, ³Department of Surgery, HUG, Geneva, Switzerland, ⁴Department of Pathology, HUG, Geneva, Switzerland, ⁵Department of Radiology, HUG, Geneva, Switzerland, ⁶Department of Transplantation, CHUV, Lausannne, Switzerland, ⁷Department of Vascular Surgery, CHUV, Lausanne, Switzerland, ⁸Department of Surgery, CHUV, Lausannne, Switzerland
*Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…
2019 American Transplant Congress
CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury
S. Lee, S. Noel, J. Kurzhagen, M. Sadasivam, A. Hamad, H. Rabb
Johns Hopkins, Baltimore, MD
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…
2019 American Transplant Congress
The Molecular Profile of Kidney Allografts Unveil Specific Biomarkers for Subclinical Acute Rejection (SAR). Towards an Early Detection and a Targeted Treatment
S. N. Cox, S. Chiurlia, F. P. Schena
Schena Foundation, Valenzano-Bari, Italy
*Purpose: SAR diagnosed by protocol biopsy is an independent risk factor for chronic allograft injury. We organized a molecular study on 24 AB0 compatible cadaveric…
2019 American Transplant Congress
Utilization of Donor Kidneys with Acute Kidney Injury in Pediatric Transplantation
C. S. Hwang¹, B. Tanriover², S. Levea², D. Desai¹, V. Ariyamuthu², P. Vagefi¹, M. MacConmara¹
¹Surgery, UT Southwestern, Dallas, TX, ²Medicine, UT Southwestern, Dallas, TX
*Purpose: Donor kidneys that are otherwise healthy with acute kidney injury (AKI) are increasingly used in adult transplant programs. We sought to examine the experience…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on GFR at 1 Year
R. Heilman, A. Kumar, A. Srinivasan, M. Smith, J. Huskey, H. Khamash, A. Mathur, C. Jadlowiec, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: GFR 1-year after kidney transplantation is a marker for long term graft survival. The aim of this study is to determine the impact of…
2019 American Transplant Congress
Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia
V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on the Outcome of Graft Delayed Graft Function
C. Jadlowiec, A. Kumar, A. Srinivasan, A. Mathur, M. Smith, J. Huskey, A. Moss, H. Khamash, R. L. Heilman, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: Kidneys from deceased donors with acute kidney injury (AKI) have a higher risk of delayed graft function (DGF). The aim of this study was…
2019 American Transplant Congress
Donor Derived Cell Free DNA Initiates De-Novo Donor Specific Antibody (DSA) Responses
S. Jordan¹, D. Sawinski², S. Dholakia³
¹Cedars-Sinai, Los Angeles, CA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³CareDx, Brisbane, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury, may contribute to sensitization of the recipients’ immune system. Antigenic presentation of donor-derived nucleic acids,…
2019 American Transplant Congress
Determinants of Allograft Injury during Procurement in Deceased Donors
E. Taber-Hight¹, R. Cauwels², E. Eidbo², A. S. Paramesh³, R. Squires⁴, T. Taber¹
¹Nephrology, Indiana University, Indianapolis, IN, ²AOPO, Vienna, VA, ³Louisiana Organ Procurement Agency, New Orleans, LA, ⁴University of Oklahoma, Oklahoma City, OK
*Purpose: With the ever enlarging list of potential recipients on the transplant list, the need for deceased donor organs has become critical. Avoiding injury to…

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