Articles tagged "Renal injury"

2020 American Transplant Congress
Urinary APOA4 as a Biomarker for Chronic Renal Allograft Injury and Rapid Renal Function Decline in Kidney Transplant Recipients
H. Jeon¹, D. Shin¹, J. Oh¹, J. Park², K. Ko³, J. Kim³, S. Lee³
¹Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, ²Department of Laboratory Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, ³Department of Surgery, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of
*Purpose: Chronic renal allograft injury (CRAI) remains a major cause of allograft loss in kidney transplant recipients (KTRs). The aim of this study was to…
2020 American Transplant Congress
Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway
Q. Yuan¹, S. Hong¹, E. Szuter¹, Y. Zhao¹, E. Acheampong¹, I. Rosales¹, M. Kronenberg², P. Russell¹, J. Madsen¹, R. Colvin¹, A. Alessandrini¹
¹Massachusetts General Hospital, Boston, MA, ²La Jolla Institute for Allergy & Immunology, La Jolla, CA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2020 American Transplant Congress
Cordycepin Protects Renal Ischemia/Reperfusion Injury Through Regulating Inflammation, Apoptosis and Oxidative Stress
C. Ding, W. Xue
Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
*Purpose: Cordycepin (3’-deoxyadenosine) is a naturally occurring adenosine analogue and onem of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus…
2020 American Transplant Congress
Cyclo(His-Pro) Prevents Against Renal Injury Through Activating Nrf2-Mediated Pathway
J. Moon¹, Y. Kim¹, H. Jung², J. Kim¹, W. Ju³, H. Lee¹, J. Lee⁴, C. Lee⁵, D. Kim¹, Y. Kim¹, S. Yang⁶
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²R&D Center, NovMetaPharma Co., Ltd, Pohang, Gyeongbuk, Korea, Republic of, ³Seoul National University Biomedical Research Institute, Seoul, Korea, Republic of, ⁴Nephrology Clinic, National Cancer Center, Goyang, Korea, Republic of, ⁵Cheju Halla General Hospital, Jeju-do, Korea, Republic of, ⁶Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Cyclic(His-Pro) (CHP) is an endogenous cyclic dipeptide that has antioxidative, anti-inflammatory effect via Nuclear factor erythroid 2-related factor (Nrf2) pathway. Endogenous CHP is distributed…
2020 American Transplant Congress
Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?
N. Parajuli, A. Khakurel
University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
2019 American Transplant Congress
Utilization of Donor Kidneys with Acute Kidney Injury in Pediatric Transplantation
C. S. Hwang¹, B. Tanriover², S. Levea², D. Desai¹, V. Ariyamuthu², P. Vagefi¹, M. MacConmara¹
¹Surgery, UT Southwestern, Dallas, TX, ²Medicine, UT Southwestern, Dallas, TX
*Purpose: Donor kidneys that are otherwise healthy with acute kidney injury (AKI) are increasingly used in adult transplant programs. We sought to examine the experience…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on GFR at 1 Year
R. Heilman, A. Kumar, A. Srinivasan, M. Smith, J. Huskey, H. Khamash, A. Mathur, C. Jadlowiec, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: GFR 1-year after kidney transplantation is a marker for long term graft survival. The aim of this study is to determine the impact of…
2019 American Transplant Congress
Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia
V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on the Outcome of Graft Delayed Graft Function
C. Jadlowiec, A. Kumar, A. Srinivasan, A. Mathur, M. Smith, J. Huskey, A. Moss, H. Khamash, R. L. Heilman, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: Kidneys from deceased donors with acute kidney injury (AKI) have a higher risk of delayed graft function (DGF). The aim of this study was…
2019 American Transplant Congress
Donor Derived Cell Free DNA Initiates De-Novo Donor Specific Antibody (DSA) Responses
S. Jordan¹, D. Sawinski², S. Dholakia³
¹Cedars-Sinai, Los Angeles, CA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³CareDx, Brisbane, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury, may contribute to sensitization of the recipients’ immune system. Antigenic presentation of donor-derived nucleic acids,…

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