2020 American Transplant Congress
microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3
*Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…2020 American Transplant Congress
Understanding the Molecular Phenotype of Kidney Injury
1University of Alberta, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: The injury status of transplanted organs is a strong predictor of graft loss. We used injury-related gene expression to explore the relationship between function,…2020 American Transplant Congress
Effect of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Induced Acute Kidney Injury in Mice
*Purpose: Livers with mild to moderate steatosis have been used to expand the donor pool for transplantation. However, livers with steatosis have a propensity for…2020 American Transplant Congress
Three Year Post Co-Stimulation Blocking Agent (Belatacept) Switch Outcomes of Kidney Transplant Patients Diagnosed with Post-Transplant Thrombotic Microangiopathy
*Purpose: Thrombotic microangiopathy (TMA) can happen after kidney transplant. It may occur de novo or as a recurrent disease. De novo is usually associated with…2020 American Transplant Congress
ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models
1Angion Biomedica, Uniondale, NY, 2Virginia Commonwealth University, Richmond, VA
*Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…2019 American Transplant Congress
Treprostinil Attenuates Renal Ischemia-Reperfusion Injury in Rat
*Purpose: Kidney transplantation (KTx) is the optimal treatment for end-stage renal diseases. The surgical procedure of KTx inherently requires cold ischemic preservation and warm reperfusion…2019 American Transplant Congress
New Reactive Oxygen Species Scavenger Prevents Injury in Ischemia-Reperfusion Injury Model
University of Wisconsin, Madison, WI
*Purpose: Despite the success of preservation solutions, Ischemia-Reperfusion (IR) injury remains a significant problem for all solid organ transplants. As a result, an important, unmet…2019 American Transplant Congress
Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs
*Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…2019 American Transplant Congress
CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…2019 American Transplant Congress
The Molecular Profile of Kidney Allografts Unveil Specific Biomarkers for Subclinical Acute Rejection (SAR). Towards an Early Detection and a Targeted Treatment
Schena Foundation, Valenzano-Bari, Italy
*Purpose: SAR diagnosed by protocol biopsy is an independent risk factor for chronic allograft injury. We organized a molecular study on 24 AB0 compatible cadaveric…
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