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Articles tagged "Renal injury"

  • 2016 American Transplant Congress

    YKL-40 Predicts Renal Recovery in Deceased-Donor Transplantation.

    J. Puthumana,1 I. Hall,1 P. Reese,2 B. Schröppel,3 F. Weng,4 H. Thiessen-Philbrook,1 M. Doshi,5 V. Rao,1 C. Lee,6 J. Elias,6 L. Cantley,1 C. Parikh.1

    1Yale University School of Medicine, New Haven, CT; 2Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; 3Section of Nephrology, University Hospital, Ulm, Germany; 4Saint Barnabas Medical Center, Livingston, NJ; 5Division of Nephrology, Wayne State University School of Medicine, Detroit, MI; 6School of Medicine and Biological Sciences, Brown University, Providence, RI.

    Background Deceased-donor kidneys with acute kidney injury (AKI) are often discarded for fear of poor transplantation outcomes. Donor biomarkers that predict post-transplant renal recovery could…
  • 2016 American Transplant Congress

    Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.

    B. Schroppel,1 P. Heeger,2 I. Hall,3 M. Doshi,4 F. Weng,5 P. Reese,6 C. Parikh.3

    1University Hospital, Ulm, Germany; 2Mount Sinai School of Medicine, New York; 3Program of Applied Translational Research, Yale University School of Medicine, New Haven; 4Wayne State University, Detroit; 5Barnabas Health, Livingston; 6University of Pennsylvania, Philadelphia.

    Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…
  • 2015 American Transplant Congress

    Gradual Warming Up Perfusion Post Static Cold Storage Reduces Renal Injury

    P. Mahboub,3,1 P. Ottens,1 R. Ploeg,2 P. Martins,3 H. Leuvenink.1

    1Surgery, UMCG, Groningen, Netherlands; 2Surgery, University of Oxford, Oxford, United Kingdom; 3Surgery, UMass, Worcester, MA.

    We hypothesize that the sudden warm reperfusion after Cold Storage [CS] is detrimental for the graft and we therefore evaluated different warming-up procedures before reperfusion.Methods:Rat…
  • 2015 American Transplant Congress

    100 Protocol Renal Allograft Biopsies at 10 Years: First Look at the Tacrolimus Era

    M. Stegall,1 W. Park,1 F. Cosio,2 L. Cornell.3

    1Transplant Surgery, Mayo Clinic, Rochester, MN; 2Medicine, Mayo Clinic, Rochester, MN; 3Laboratory Medicine, Mayo Clinic, Rochester, MN.

    This study examined late renal allograft injury in the Tacrolimus era in 10-yr protocol biopsies (Bx).Methods One hundred 10-yr protocol allograft bx were assessed using…
  • 2015 American Transplant Congress

    Banff Criteria Are Inadequate to Assess Chronic Renal Allograft Injury 10 Years Post-Transplantation

    L. Cornell, W. Park, F. Cosio, M. Stegall.

    Mayo Clinic, Rochester, MN.

    Background: The Banff criteria have been developed to assess acute and chronic injury in renal allografts. However, the criteria have been based on biopsies for…
  • 2015 American Transplant Congress

    Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies

    J. Venner, J. Reeve, P. Halloran.

    University of Alberta, Edmonton, Canada.

    Irreversible injury in organ transplants is an important clinical parameter, and is estimated by histology as the observed “ci” lesion, but with considerable inter-observer variability…
  • 2015 American Transplant Congress

    Surgical Error: A Common, Preventable Threat to Deceased Donor Organs

    A. Friedman,1 T. Diflo,2 S. Florman,3 L. Ratner,4 E. Marquez,1 W. Tajik.1

    1New York Organ Donor Network, New York, NY; 2Westchester Medical Center, Valhalla, NY; 3Mount Sinai School of Medicine, New York, NY; 4Columbia Presbyterian Medical Center, New York, NY.

    Deceased donor procurements (N = 340) performed through a single organ procurement organization during a 19 month period from 7/1/13 - 11/30/14 were reviewed through…
  • 2015 American Transplant Congress

    Acute Kidney Injury After Lung Transplantation – Incidence, Risk Factors and Mechanisms

    F. Gueler,1 G. Warnecke,5 M. Peperhove,2 M.-S. Jang,1 C. Schroeder,3 S. Tewes,2 B. Wiese,6 C. Fegbeutel,5 R. Lichtinghagen,7 B. Jüttner,8 F. Wacker,2 D. Hartung,2 B. Akerstrom,4 M. Gram,4 H. Haller,1 A. Haverich,9 K. Hueper.2

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Radiology, Hannover Medical School, Hannover, Germany; 3Proteomics, German Research Cancer Center, Heidelberg, Germany; 4Physiology, Lund University, Lund, Sweden; 5Thoracic and Cardiac Surgery, Hannover Medical School, Hannover, Germany; 6Medical Statistics, Hannover Medical School, Hannover, Germany; 7Laboratory Medicine, Hannover Medical School, Hannover, Germany; 8Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany; 9Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.

    Background: Acute kidney injury (AKI) is a frequent and severe complication after solid organ transplantation. In a retrospective analysis and afterwards in a prospective clinical…
  • 2015 American Transplant Congress

    Renal Tubular Dysfunction Following Donor Nephrectomy and Its Impact On Residual Kidney Function

    Z. Ahmed,1 C. Rooney,3 C. Turner,2 N. Dalton,2 N. Kessaris,1 N. Mamode.1

    1Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom; 2Wellchild Laboratory, St Thomas' Hospital, London, United Kingdom; 3Faculty of Medicine, King's College London, London, United Kingdom.

    Background: Recent publications have described an increasing incidence of end stage renal disease amongst kidney donors. This highlights the paucity of knowledge which exists in…
  • 2015 American Transplant Congress

    Prospective Measurement of Plasma Neutrophil Gelatinase-Associated Lipoprotein in Living Kidney Donors

    Y. Yoon,1 K. Choi,2 D. Joo,3 K. Huh,3 M. Kim,3 S. Kim,3 Y. Kim,3 S. Yang,2 W. Han.1

    1Department of Urology, Yonsei University College of Medicine, Seoul, Korea; 2Department of Urology, CHA University, Seongnam-si, Korea; 3Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.

    Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL…
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