Articles tagged "Renal injury"

2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
D. Aufhauser, D. Murken,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.
M. Menon,¹ L. Liriano-Ward,² N. Philippe,¹ C. Wei,¹ W. Zhang,¹ Z. Yi,¹ K. Keung,² P. O'Connell,² B. Murphy.¹
¹Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, Westmead Millenium Institute, Sydney, NSW, Australia
The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
2017 American Transplant Congress
Postoperative Serum Lactate Dehydrogenase Is a "Troponin-Like" Marker of Renal Transplant Distress.
R. Steiner, J. Halldorson.
UCSD Center for Transplantation, University of California at San Diego, San Diego, CA
Lactate dehydrogenase (LDH) is plentiful in renal tubular cells and is released during tubular injury or death. It increases for several days to 1500-2000 U/L…
2017 American Transplant Congress
Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.
M. Thomas, G. Tardif, A. Melanger, P. Berna.
Balmes Transplantation, Marseille, France
Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2017 American Transplant Congress
Relationship of Liver Extraction Times to Early Allograft Dysfunction and Post-Transplant Kidney Injury.
D. Simpson, M. Gupta, C. McAllister, P. Porrett, D. Goldberg, M. Levine, K. Olthoff, A. Shaked, P. Abt.
Hospital of the University of Pennsylvania, Philadelphia, PA
Background: Donor extraction times for kidney allografts are associated with inferior kidney outcomes. We hypothesized that that longer donor liver extraction times would be associated…
2017 American Transplant Congress
Utility of Electron Microscopy in Kidney Transplant Biopsies.
J. Grodsky,¹ R. Craver,^1,2 I. Ashoor.²
¹LSUHSC, New Orleans, LA; ²Children's Hospital, New Orleans, LA
Background: Banff 2013 criteria recommends performing ultra-structural studies with electron microscopy (EM) in most kidney transplant (KT) biopsies if the technology is available. We aimed…
2017 American Transplant Congress
The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.
G. Weber,¹ N. Ambrosi,² F. Caro,² S. Beltramino,¹ A. Fernández,¹ I. Cabrera,¹ G. Hilchenbach,¹ D. Fernandez,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; ²CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; ³Fundación GADOR, Buenos Aires, Argentina
A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…