Articles tagged "Renal injury"

2018 American Transplant Congress
Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)
B. Fuhrmann,^1,5 D. Lian,⁵ Z. Yin,⁵ S. Ma,^4,5 J. Arp,⁵ Z. Zhang,^2,3,4,5 A. Jevnikar.^1,3,4,5
¹Microbiology and Immunology, Western University, London, Canada; ²Pathology, Western University, London, Canada; ³Medicine, Western University, London, Canada; ⁴Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; ⁵Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
2017 American Transplant Congress
The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.
G. Weber,¹ N. Ambrosi,² F. Caro,² S. Beltramino,¹ A. Fernández,¹ I. Cabrera,¹ G. Hilchenbach,¹ D. Fernandez,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; ²CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; ³Fundación GADOR, Buenos Aires, Argentina
A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
2017 American Transplant Congress
Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.
J. Kim,¹ H. Ahn,² D. Kim,¹ S. Jung,¹ E. Park,¹ T. Lee,¹ C. Ihm,¹ S. Lee,¹ J. Moon,¹ Y. Kim,¹ K. Jeong.¹
¹Nephrology, Kyung Hee University Medical Center, Seoul, Korea; ²Surgery, Kyung Hee University Medical Center, Seoul, Korea
Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…
2017 American Transplant Congress
Efficacy of Calcineurin Inhibitors Transferring to Rapamycin in Live Kidney Transplantation from Old Donors to Young Recipients.
G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Calcineurin inhibitor(CNI) nephrotoxicity is one of the major reasons for chronic allograft injury in live kidney transplantation from old donors to young recipients. Therefore…
2017 American Transplant Congress
Pre-OLT CKD-3 Increases Post-OLT ESRD and AKI Impacts Early Post-OLT Survival.
G. Faddoul, L. Liriano-Ward, P. Chang, Y. Azzi, K. Chauhan, G. Nadkarni, V. Nair, R. Kent, S. Lerner, S. Coca, P. Heeger, S. Florman, S. Thomas, M. Menon.
Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, Irvington, NY
Current combined Liver-kidney allocation protocols allocate dual organs based on sustained glomerular filtration rates (eGFR) of 30ml/min or less. It is unclear whether milder renal…
2017 American Transplant Congress
The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.
T. Yagisawa,^1,2 T. Tanaka,¹ N. Dvorina,¹ A. Valujskikh,¹ W. Baldwin 3rd,¹ R. Fairchild.¹
¹Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH; ²Urology, Tokyo Women's Medical University, Tokyo, Japan
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
M. Xu,¹ B. Banan,¹ X. Wang,¹ D. Chirumbole,¹ B. Rabe,¹ S. Garcia-Aroz,¹ D. Nayak,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ J. Gaut,² P. Manning,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Washington University School of Medicine, St. Louis; ²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; ³Tioma Therapeutics, Inc, St. Louis
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
2017 American Transplant Congress
Hepatic Ischemia Reperfusion Injury After Liver Transplantation Is Associated with Acute Kidney Injury.
S. Kubal,¹ M. Anderson,² J. Fridell,¹ B. Ekser,¹ T. Taber,² P. Li,¹ M. Ghabril,³ M. Lacerda,³ R. Mangus.¹
¹Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; ²Department of Nephrology, Indiana University School of Medicine, Indianapolis, IN; ³Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN
Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that severity of IRI correlates with…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…