2018 American Transplant Congress
Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function
University of Alberta, Edmonton, Canada.
With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…2017 American Transplant Congress
Relationship of Liver Extraction Times to Early Allograft Dysfunction and Post-Transplant Kidney Injury.
Hospital of the University of Pennsylvania, Philadelphia, PA
Background: Donor extraction times for kidney allografts are associated with inferior kidney outcomes. We hypothesized that that longer donor liver extraction times would be associated…2017 American Transplant Congress
Utility of Electron Microscopy in Kidney Transplant Biopsies.
1LSUHSC, New Orleans, LA; 2Children's Hospital, New Orleans, LA
Background: Banff 2013 criteria recommends performing ultra-structural studies with electron microscopy (EM) in most kidney transplant (KT) biopsies if the technology is available. We aimed…2017 American Transplant Congress
The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.
A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…2017 American Transplant Congress
Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.
Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…2017 American Transplant Congress
Efficacy of Calcineurin Inhibitors Transferring to Rapamycin in Live Kidney Transplantation from Old Donors to Young Recipients.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Calcineurin inhibitor(CNI) nephrotoxicity is one of the major reasons for chronic allograft injury in live kidney transplantation from old donors to young recipients. Therefore…2017 American Transplant Congress
Pre-OLT CKD-3 Increases Post-OLT ESRD and AKI Impacts Early Post-OLT Survival.
Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, Irvington, NY
Current combined Liver-kidney allocation protocols allocate dual organs based on sustained glomerular filtration rates (eGFR) of 30ml/min or less. It is unclear whether milder renal…2017 American Transplant Congress
The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
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