ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal injury"

  • 2022 American Transplant Congress

    Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection

    A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg

    University of Maryland, Baltimore, MD

    *Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
  • 2022 American Transplant Congress

    Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration

    Y. Shim1, R. Fan2, N. Dvorina2, K. McCrae1, B. William2

    1Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 2Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH

    *Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
  • 2022 American Transplant Congress

    CD38 Knockout Mice Demonstrate Decreased Neutrophil Infiltration Following Renal Ischemia Reperfusion Injury

    I. Woelfel1, A. Ruffing1, I. El-Ayachi1, K. Washburn2, S. Black1, A. Schenk1

    1Ohio State University, Columbus, OH, 2The Ohio State University, Columbus, OH

    *Purpose: Ischemia reperfusion injury (IRI) perpetuates inflammation and causes significant organ injury in solid organ transplantation. CD38 is a ectoenzyme widely expressed on lymphocytes with…
  • 2022 American Transplant Congress

    Early Post-Operative Thrombotic Microangiopathy in Deceased Donor Kidney Transplant: A Retrospective Case Series

    R. Seneriz1, A. Mattiazzi1, G. Guerra1, T. Harrington2, M. Velasquez3

    1Miami Transplant Institute, Miami, FL, 2University of Miami, Miami, FL, 3Jackson Memorial Hospital, Miami, FL

    *Purpose: Transplant associated thrombotic microangiopathy (TA-TMA) is characterized by endothelial injury along with thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and kidney graft dysfunction. It can be…
  • 2022 American Transplant Congress

    Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation

    E. Hafiz1, W. H. El-Maadawy2, M. Hassan3, M. H. Badawy4, S. Eldahshan4, A. AbuSeada5

    1Clinical Research Laboratory Department, Theodor Bilharz Research Institute, Giza, Egypt, 2Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt, 3Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt, 4Urology Department, Theodor Bilharz Research Institute, Giza, Egypt, 5Anesthesia Department, Theodor Bilharz Research Institute, Giza, Egypt

    *Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…
  • 2022 American Transplant Congress

    Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids

    A. Kumar Gupta1, E. Minocha1, J. A. Wertheim1, L. Gallon2

    1Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
  • 2022 American Transplant Congress

    The Impact of COVID-19 on Renal Function of Kidney Transplant Recipients: A Three-Month Prospective Study

    R. D. Foresto1, H. Fagundes2, V. Lafico2, H. Tedesco Silva Junior2, M. P. Cristelli1, J. Pestana1

    1Hospital do Rim, Sao Paulo, Brazil, 2Hospital do Rim, Universidade Federal de São Paulo, SAo Paulo, Brazil

    *Purpose: This study aimed to assess changes in renal function during the acute disease and up to three months after the onset of symptoms among…
  • 2022 American Transplant Congress

    Cell-Free DNA Concentration in Hypothermic Machine Perfusate is a Potential Rapid Marker for Kidney Graft Quality

    S. Duarte1, M. Willman1, V. Boominathan1, D. Lewis1, W. De Faria1, G. Vrakas1, A. El-Hinnawi1, T. Beduschi1, N. Battula2, A. Zarrinpar1

    1University of Florida, Gainesville, FL, 2University of Oklahoma Medical College, Oklahoma City, OK

    *Purpose: The successful use of hypothermic machine perfusion (HMP) as a clinical modality for graft preservation prior to kidney transplantation (KTx) has generated a demand…
  • 2022 American Transplant Congress

    Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function

    K. Lee, E. A. Thompson, C. H. Patel, S. Gharaie, J. T. Kurzhagen, S. Noel, P. M. Pierorazio, B. S. Slusher, H. Rabb

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…
  • 2022 American Transplant Congress

    M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod

    M. Zheng1, W. Zijie2, Z. Gui3, R. Tan1, M. Gu3

    1Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2Jiangsu Province Hospital, Nanjing, China, 3Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China

    *Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…
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