Articles tagged "Renal injury"

2022 American Transplant Congress
Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection
A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg
University of Maryland, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
Y. Shim¹, R. Fan², N. Dvorina², K. McCrae¹, B. William²
¹Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, ²Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
2022 American Transplant Congress
CD38 Knockout Mice Demonstrate Decreased Neutrophil Infiltration Following Renal Ischemia Reperfusion Injury
I. Woelfel¹, A. Ruffing¹, I. El-Ayachi¹, K. Washburn², S. Black¹, A. Schenk¹
¹Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH
*Purpose: Ischemia reperfusion injury (IRI) perpetuates inflammation and causes significant organ injury in solid organ transplantation. CD38 is a ectoenzyme widely expressed on lymphocytes with…
2022 American Transplant Congress
Early Post-Operative Thrombotic Microangiopathy in Deceased Donor Kidney Transplant: A Retrospective Case Series
R. Seneriz¹, A. Mattiazzi¹, G. Guerra¹, T. Harrington², M. Velasquez³
¹Miami Transplant Institute, Miami, FL, ²University of Miami, Miami, FL, ³Jackson Memorial Hospital, Miami, FL
*Purpose: Transplant associated thrombotic microangiopathy (TA-TMA) is characterized by endothelial injury along with thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and kidney graft dysfunction. It can be…
2022 American Transplant Congress
Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation
E. Hafiz¹, W. H. El-Maadawy², M. Hassan³, M. H. Badawy⁴, S. Eldahshan⁴, A. AbuSeada⁵
¹Clinical Research Laboratory Department, Theodor Bilharz Research Institute, Giza, Egypt, ²Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt, ³Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁴Urology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁵Anesthesia Department, Theodor Bilharz Research Institute, Giza, Egypt
*Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…
2022 American Transplant Congress
Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids
A. Kumar Gupta¹, E. Minocha¹, J. A. Wertheim¹, L. Gallon²
¹Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, ²Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
2022 American Transplant Congress
The Impact of COVID-19 on Renal Function of Kidney Transplant Recipients: A Three-Month Prospective Study
R. D. Foresto¹, H. Fagundes², V. Lafico², H. Tedesco Silva Junior², M. P. Cristelli¹, J. Pestana¹
¹Hospital do Rim, Sao Paulo, Brazil, ²Hospital do Rim, Universidade Federal de São Paulo, SAo Paulo, Brazil
*Purpose: This study aimed to assess changes in renal function during the acute disease and up to three months after the onset of symptoms among…
2022 American Transplant Congress
Cell-Free DNA Concentration in Hypothermic Machine Perfusate is a Potential Rapid Marker for Kidney Graft Quality
S. Duarte¹, M. Willman¹, V. Boominathan¹, D. Lewis¹, W. De Faria¹, G. Vrakas¹, A. El-Hinnawi¹, T. Beduschi¹, N. Battula², A. Zarrinpar¹
¹University of Florida, Gainesville, FL, ²University of Oklahoma Medical College, Oklahoma City, OK
*Purpose: The successful use of hypothermic machine perfusion (HMP) as a clinical modality for graft preservation prior to kidney transplantation (KTx) has generated a demand…
2022 American Transplant Congress
Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function
K. Lee, E. A. Thompson, C. H. Patel, S. Gharaie, J. T. Kurzhagen, S. Noel, P. M. Pierorazio, B. S. Slusher, H. Rabb
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…
2022 American Transplant Congress
M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod
M. Zheng¹, W. Zijie², Z. Gui³, R. Tan¹, M. Gu³
¹Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…

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