Articles tagged "Renal failure"

2022 American Transplant Congress
Revolutionizing Clinical Diagnostic Models for Acute Rejection Using Generative Adversarial Networks
W. Yazar¹, R. Nijor¹, R. Sarwal¹, N. Titzler¹, M. Sarwal², S. Ghosh¹
¹Nephrosant, Brisbane, CA, ²NephroSant, Brisbane, CA
*Purpose: Data heterogeneity, incompleteness and class-imbalance, hallmarks of real world healthcare data (RWHD), pose long-standing challenges to the accuracy of AI-based models. This research evaluates…
2022 American Transplant Congress
Meta-Analysis of the Chronic Exposure to Calcineurin Inhibitors and the Risk for Chronic and End-Stage Kidney Disease in Non-Renal Solid Organ Transplant Recipients
A. Alvarez Elias¹, M. Riedl¹, D. Stewart², A. Ruco³, P. Bobos³, S. Maharaj⁴, V. Shah⁵, E. Uleryk⁶, C. Teoh¹, R. Parekh¹
¹Hospital for Sick Children, Toronto, ON, Canada, ²Royal Hospital for Children, Glasgow, United Kingdom, ³St. Michael’s Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Mount Sinai Hospital, Toronto, ON, Canada, ⁶E. M. Uleryk Consulting, Toronto, ON, Canada
*Purpose: Calcineurin inhibitors (CNI) are standard of care immunosuppressants among all solid organ transplant (SOT) recipients, and the most common side effect is nephrotoxicity. There…
2021 American Transplant Congress
A Payer’s Perspective: The Cost of Hemodialysis versus Living Donor Kidney Transplant for Kidney Failure Patients in Nigeria
J. Lang¹, I. James², D. Da Rocha Afodu¹, C. G. Okwuonu³, O. Ekwenna¹
¹University of Toledo College of Medicine and Life Sciences, Toledo, OH, ²Surgical Specialists of Charlotte, Matthews, NC, ³Department of Internal Medicine, Nephrology Unit, Federal Medical Centre, Umuahia, Abia State, Nigeria
*Purpose: To primarily quantify the costs of LDKT and HD in Nigeria from a ‘payer’s perspective’ and secondarily inform future cost-effectiveness studies to guide health…
2021 American Transplant Congress
Simultaneous Heart-Liver-Kidney Transplantation Survival: National and Single-Center Outcomes
U. A. Siddiqi¹, P. S. Combs¹, G. Kim², T. Baker³, Y. Becker¹, V. Jeevanandam¹
¹Section of Cardiac Surgery, University of Chicago Medicine, Chicago, IL, ²Section of Cardiology, University of Chicago Medicine, Chicago, IL, ³University of Chicago Medicine, Chicago, IL
*Purpose: Simultaneous Heart-Liver-Kidney transplantation (SHLKTx) is an incredibly rare, high-risk operation undergone by well-selected patients presenting with multi-organ failure. Our center has performed 10 of…
2021 American Transplant Congress
BK Virus-associated Nephropathy as a Cause of Renal Failure Post-lung Transplantation
A. Arjuna, M. T. Olson, B. Buddhdev, R. Tenorio, A. Omar, S. Tokman
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: BK virus-associated nephropathy (BKVAN) is a common cause of renal dysfunction early after renal transplant. BKVAN is much rarer in non-renal solid organ transplant,…
2021 American Transplant Congress
Impact of Advanced Renal Dysfunction on Post-Transplant Outcomes After Living Donor Liver Transplantation in the United States
T. Bittermann¹, N. Kaur², P. L. Abt¹, K. M. Olthoff¹, J. K. Heimbach³, J. Emamaullee²
¹University of Pennsylvania, Philadelphia, PA, ²University of Southern California, Los Angeles, CA, ³Mayo Clinic College of Medicine, Rochester, MN
*Purpose: Survival after living donor liver transplantation (LDLT) in the U.S. is excellent. However, the significance of pre-transplant kidney disease on outcomes after LDLT is…
2021 American Transplant Congress
Covid-19 in Solid Organ Transplantation (SOT): Results of the National Covid Cohort Collaborative (N3C)
G. Agarwal¹, A. Vinson², R. Dai³, E. French⁴, S. Lee⁵, A. Olex⁴, A. Anzalone⁶, V. Madhira⁷, R. B. Mannon⁸
¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Medicine/Nephrology, Nova Scotia Health Authority, Halifax, NS, Canada, ³Biostatistics, University of Nebraska Medical Center, Omaha, NE, ⁴Wright Center for Clinical and Translational Research, VIrginia Commonwealth University, Richmond, VA, ⁵Medicine/Infectious Disease, University of Saskatchewan, Saskatoon, SK, Canada, ⁶Neurology, University of Nebraska Medical Center, Omaha, NE, ⁷Palia Software, Not sure, OR, ⁸Medicine/Nephrology, University of Nebraska Medical Center, Omaha, NE
*Purpose: SARS-CoV-2 infection has resulted in significant mortality in solid organ transplant (SOT) recipients based on reports from single centers or voluntary registries. The N3C…
2021 American Transplant Congress
Outcomes of Transjugular Intrahepatic Portosystemic Shunts (TIPS) in Dialysis-Dependent ESLD Patients: The ALTA Study
J. Ge¹, J. Boike², M. German³, G. J. Morelli⁴, E. Spengler³, A. Said³, A. S. Lee³, A. Hristov³, A. Desai⁵, T. Couri⁶, S. Paul⁶, C. Frenette⁷, N. Christian-Miller⁷, M. Laurito⁸, E. Verna⁸, U. Rahim⁹, A. Goel⁹, D. Gregory², L. VanWagner², K. P. Kolli¹, J. Lai¹
¹University of California, San Francisco, San Francisco, CA, ²Northwestern Memorial Hospital, Chicago, IL, ³University of Wisconsin, Madison, WI, ⁴University of Florida Health, Gainsville, FL, ⁵Indiana University School of Medicine, Indianapolis, IN, ⁶University of Chicago, Chicago, IL, ⁷The Scripps Clinic, La Jolla, CA, ⁸Columbia University, New York, NY, ⁹Stanford University, Stanford, CA
*Purpose: Data on the outcomes of patients with cirrhosis who require renal replacement therapy (RRT) at the time of transjugular intrahepatic portosystemic shunts (TIPS) is…
2021 American Transplant Congress
Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding
P. Halloran¹, J. Reeve¹, G. Böhmig², O. Viklicky³, M. Myslak⁴, G. Gupta⁵, &. the INTERCOMEX Study Group⁶
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Pomeranian Medical University, Szczecin, Poland, ⁵Virginia Commonwealth University, Richmond, VA, ⁶., ., AB, Canada
*Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…
2021 American Transplant Congress
Post-Transplant Idiopathic Immune Complex Glomerulonephritis
F. Aziz, T. Singh, N. Garg, D. Mandelbrot
University of Wisconsin, Madison, WI
*Purpose: The appropriate treatment for post-kidney transplant immune complex glomerulonephritis (ICGN) of unknown cause is unclear.*Methods: From 01/2004 to 12/2018, 71 patients were diagnosed with…