Articles tagged "Renal dysfunction"

2015 American Transplant Congress
Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation
O. Bestard,^1,2 E. Crespo,¹ T. Sigdel,² S. Roedder,² Y. Ng,² J. Cruzado,¹ M. Lúcia,¹ S.-C. Hsieh,¹ T. Tran,¹ J. Grinyó,¹ M. Sarwal.¹
¹Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, CAT, Spain; ²Department of Transplant Surgery, UCSF, San Francisco, CA.
Subclinical allograft rejection (sc-AR) is still a main cause of allograft loss that can only be assessed through invasive surveillance biopsies. We sought to investigate…
2015 American Transplant Congress
Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy
D. Toki,¹ H. Ishida,¹ M. Okumi,¹ T. Shimizu,¹ H. Shirakawa,¹ M. Inui,¹ K. Omoto,¹ K. Unagami,¹ T. Kanzawa,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Pathology, Tama Hospital, Kanagawa, Japan.
PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…
2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
2015 American Transplant Congress
Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney
R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.
Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland.
EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
2015 American Transplant Congress
Calcineurin Inhibitors (CNI) Minimization Associated With Mammalian Target of Rapamycin Inhibitors (i-mTOR) to Improve Renal Function in Renal Grafts from Uncontrolled Donation After Cardiac Death Donors (UDCDD)
M. Molina,¹ E. Gutierrez,¹ S. González-Sanchidrian,² E. González,¹ J. Cabrera,¹ N. Polanco,¹ A. Hernández,¹ A. Sevillano,¹ M. Praga,¹ A. Andres.¹
¹Nephrology, Hospital 12 de Octubre, Madrid, Spain; ²Nephrology, Hospital San Pedro de Alcántara, Caceres, Spain.
INTRODUCTION: Ischemia injury in kidneys grafts from UDCDD could produce a poor renal function. Minimized blood levels of CNI associated with i-mTOR therapy could avoid…
2015 American Transplant Congress
Correlation of Serum Creatinine-Based Equations With Radionuclide GFR in Candidates for Liver Transplantation
A. Alqallaf, A. Alam, P. Ghali, M. Cantarovich.
McGill University Health Centre, Montreal, QC, Canada.
Background: Renal dysfunction is common prior to liver transplantation (LTx); however, the best way to determine the glomerular filtration rate (GFR) pre-LTx is unclear. Our…
2015 American Transplant Congress
Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies
J. Venner, J. Reeve, P. Halloran.
University of Alberta, Edmonton, Canada.
Irreversible injury in organ transplants is an important clinical parameter, and is estimated by histology as the observed “ci” lesion, but with considerable inter-observer variability…
2015 American Transplant Congress
Long-Term Results After Heart Transplantation – A Randomized Trial Comparing Tacrolimus Versus Cyclosporine A in Combination With Mycophenolate Mofetil After a Mean Duration of 15 Years
S. Guethoff,¹ C. Grinninger,¹ B. Reichart,² P. Ueberfuhr,¹ C. Hagl,¹ B. Meiser.²
¹Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; ²Transplantation Center, Ludwig-Maximilians University, Munich, Germany.
Purpose. Development of cardiac allograft vasculopathy (CAV), renal dysfunction and malignancies are the main risks due to long-term immunosuppressive therapy after heart transplantation (HTx). We…
2015 American Transplant Congress
Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease
S. Gonzalez,¹ J. Trotter,¹ H. Szerlip,² M. Levy,³ A. Chandrakantan,⁴ A. Yango,⁴ A. Rajagopal,⁴ Y. Barri,⁴ K. Rice,⁴ M. Saim,² L. Melton,⁴ M. Emmett,² G. Klintmalm,³ B. Fischbach.⁴
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Nephrology, Baylor University Medical Center, Dallas, TX; ³Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; ⁴Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.
Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…
2015 American Transplant Congress
A Joint Survival Longitudinal Approach to Better Assess the Etiological Role of Risk Factors of Kidney Transplant Graft Failure
M.-C. Fournier,^1,2 E. Dantan,¹ Y. Foucher,^1,2 M. Giral.²
¹EA 4275 - SPHERE - Biostatistique, Pharmacoépidémiologie et Mesures Subjectives en Santé, Université de Nantes, Nantes, France; ²INSERM CR1064 Centre pour la Recherche en Transplantation et Immunointervention (CRTI), Institut Transplantation-Urologie-Néphrologie (ITUN), Nantes, France.
Background. Although risk factors of graft failure after renal transplantation have been widely considered, it is difficult to distinguish their etiological role: a direct association…