Articles tagged "Rejection"

2018 American Transplant Congress
Impact of Psychosocial Variables on Renal Allograft Rejection Risk: A Multivariate Analysis
D. Chernobylsky, K. Carsky, C. McDermott, P. Ferrin, R. Fernandez, I. Gaines, M. Killackey, R. Zhang, A. Paramesh, J. Buell.
Transplant Surgery, Tulane University School of Medicine, New Orleans, LA.
Transplant-specific risk factors for rejection are well documented, yet psychosocial variable correlation with rejection risk is not; this analysis seeks to determine the relationship between…
2018 American Transplant Congress
Reassessment of Virtual Crossmatch: The Clinical Meaning of Cell-Based Actual Crossmatch for Kidney Transplantation
B. Peng,^1,2 M. Yu,^1,2 Q. Zhuang,^1,2 H. Liu,^1,2 L. Zhu,^1,2 Y. Liu,^1,2 K. Cheng,^1,2 Y. Ming.^1,2
¹Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; ²Engineering & Technology Research Center for Transplantation Medicine, National Ministry of Health, Changsha, Hunan, China.
Background: Due to the high sensitivity and specificity of Luminex technique, the Luminex single antigen beads (LSAB) assays are widely used in detecting the HLA…
2018 American Transplant Congress
Clinical Significance of Tacrolimus Trough Level at the Early Period after Kidney Transplantation
W. Park,^1,2 S. Yeo,¹ S. Kang,^1,2 H. Park,¹ K. Jin,^1,2 S. Park,^1,2 S. Han.^1,2
¹Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; ²Keimyung University Kidney Institute, Daegu, Republic of Korea.
Background:The stable immunosuppressant level at the early period after kidney transplantation (KT) is one of the most important factors to decide the prognosis of KT.…
2018 American Transplant Congress
Does DGF Result in Worse Outcomes in a Second Transplant?
B. Muth,¹ B. Astor,^1,2 J. Blazel,¹ J. Turk,¹ D. Mandelbrot,¹ A. Djamali,¹ S. Parajuli.¹
¹Department of Medicine, University of Wisconsin, Madison, WI; ²Department of Population Health, University of Wisconsin, Madison, WI.
Delayed graft function (DGF) is a risk factor for patient death, kidney allograft loss, reduced allograft function and acute rejection after kidney transplantation. Prior transplant…
2018 American Transplant Congress
Single-Dose Basiliximab Induction in Liver Transplant Recipients with Delayed CNI Initiation
D. Salerno,¹ N. Lange,¹ R. Rosenblatt,² C. Sammons,³ B. Fortune.²
¹Pharmacy, NewYork-Presbyterian Hospital, New York, NY; ²Medicine, Weill Cornell Medicine, New York, NY; ³Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA.
Liver transplant recipients (LTR) with peri-operative renal injury benefit from a delayed CNI protocol using basiliximab (IL2RA) induction to reduce early CNI exposure. Existing literature…
2018 American Transplant Congress
Belatacept in Kidney Transplant Recipients with Preformed Donor Specific Anti-HLA Antibodies: Results of the BELACOR Trial
C. Leibler,¹ F. Canoui,² M. Matignon,¹ E. Rondeau,³ A. Zarour,² A. Durrbach,⁴ S. Malard,⁵ P. Grimbert.¹
¹Nephrology Transplantation, APHP Henri Mondor, Creteil, France; ²Public Health, APHP Henri Mondor, Creteil, France; ³Nephrology Transplantation, APHP Tenon, Paris, France; ⁴Nephrology Transplantation, APHP Bicêtre, Le Kremlin Bicêtre, France; ⁵Histocompatibility, APHP Saint Louis, Paris, France.
IntroductionAntibody-mediated rejection (ABMR) is currently a critical question in kidney transplant recipient with immunological risk factors such as pre transplant donor-specific anti HLA antibodies (DSA).…
2018 American Transplant Congress
Chronic Antibody Mediated Rejection in Renal Allografts Shows RNA Transcript Patterns That Evolve with Stage
A. Rosales,¹ B. Adam,² M. Mengel,² T. Oura,¹ M. Matsunami,¹ T. Kawai,¹ A. Cosimi,¹ R. Smith,¹ R. Colvin.¹
¹Massachusetts General Hospital, Boston, MA; ²University of Alberta, Edmonton, AB, Canada.
Purpose. Four stages of chronic antibody mediated rejection (CAMR) in renal allografts have been defined in humans and non-human primates (NHP), beginning with donor specific…
2018 American Transplant Congress
Macrophage Depletion of RCMV-Latently Infected Allografts Ameliorates Accelerated Chronic Cardiac Rejection
J. Burg,¹ N. Haese,² T. Andoh,² C. Kreklywich,² I. Jones,² S. Orloff,¹ D. Streblow.²
¹Abdominal Organ Transplantation, OHSU, Portland, OR; ²VGTI, OHSU, Portland, OR.
PurposeLatent donor rat cytomegalovirus (RCMV) infection accelerates chronic rejection (CR) in a heterotopic rat heart transplant model. RCMV latency is associated with an influx of…
2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
H. Dai,¹ P. Lan,² A. Friday,¹ A. Williams,¹ M. Oberbarnscheidt,¹ X. Li,² F. Lakkis.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Immunobiology, Houston Methodist Hospital, Houston, TX.
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…
2018 American Transplant Congress
Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
The importance of antibody-mediated rejection (ABMR) on the renal transplant recipients has been recognized in recent years. However, the pathogenesis of ABMR following kidney transplantation…