Articles tagged "Rejection"

2018 American Transplant Congress
Efficacy and Safety of Tocilizumab in Treatment of Acute Antibody Mediated Rejection
K. Venkatachalam, D. Reem, M. Andrew, R. Delos Santos, T. Alhamad.
Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Ohio State University, Columbus, OH; Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Washington University, Saint Louis, MO.
Antibody mediated rejection continues to be one of the most detrimental complications of kidney transplant. Multiple therapeutic strategies focused on B cell and/or HLA antibody…
2018 American Transplant Congress
Enteric Conversion of Bladder Drained Pancreas as a Time Dependent Predictor of Outcomes in over 900 Recipients
S. Riad,¹ D. Keys,¹ V. Vakil,¹ S. Jackson,² D. Berglund,² A. Matas,³ R. Kandaswamy.³
¹Renal Disease and Hypertension, University of Minnesota, Minneapolis, MN; ²Informatics Services for Research and Reporting, Fairview Health Service, Minneapolis, MN; ³Transplant Surgery, University of Minnesota, Minneapolis, MN.
Background: Bladder drainage in pancreas transplantation technique has declined due to concern over complications such as severe dehydration, acidosis, hemorrhagic cystitis and recurrent urinary infections…
2018 American Transplant Congress
Defining T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
G. Furtmueller,¹ V. Malek,¹ B. Oh,¹ S. Reddy,¹ M. Iglesias,¹ G. Raimondi,¹ G. Brandacher, D. Cooney.
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; ²Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore.
BackgroundVascularized Composite Allotransplantation (VCA) is a clinically feasible therapeutic option for complex tissue defects. The highly immunogenic skin component of VCA represents a therapeutic challenge…
2018 American Transplant Congress
Early Life Stress Exposure and Cardio-Renal Outcomes in Pediatric Kidney Transplantation
M. Seifert, P. Perry, R. Romp, R. Mannon, J. Pollock.
UAB School of Medicine, Birmingham.
Purpose: Early life stress (ELS) has emerged as an important cardiovascular risk factor in adulthood, and can be characterized by exposure to adverse childhood experiences…
2018 American Transplant Congress
Functional Fc Gamma Receptor Gene Polymorphisms and Donor-Specific Antibody-Triggered Transplant Injury
M-.L. Arnold,¹ A. Kainz,² F. Eskandary,² N. Kozakowski,³ M. Wahrmann,² H. Haslacher,⁴ R. Oberbauer,² A. Heilos,⁵ B. Spriewald,⁶ L. Hidalgo,⁷ P. Halloran,⁸ G. Bohmig.²
¹Department of Internal Medicine 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ²Department of Medicine III, Medical University of Vienna, Vienna, Austria; ³Department of Pathology, Medical University of Vienna, Vienna, Austria; ⁴Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; ⁵Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; ⁶Department of Internal Medicine 5, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ⁷Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁸Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.
Fc-dependent effector mechanisms may play an important role in antibody-mediated rejection (ABMR). Distinct gene polymorphisms may determine the function of Fc gamma receptors (FcγR), potentially…
2018 American Transplant Congress
Long-Term Prognosis of BK Virus Associated Nephropathy in Kidney Transplant Recipients
W. Park,^1,3 S. Yeo,¹ S. Kang,^1,3 H. Park,¹ K. Jin,^1,3 S. Park,^1,3 M. Choe,^2,3 S. Han.^1,3
¹Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; ²Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea; ³Keimyung University Kidney Institute, Daegu, Republic of Korea.
Background: BK virus-associated nephropathy (BKVAN) is an important risk factor that results in an allograft loss in kidney transplant recipients (KTRs). The short-term prognosis of…
2018 American Transplant Congress
Treatment of HCV Infection in Renal Transplant Recipients
M. Rial, L. Tana, C. Alonso, H. Curcio, E. Chulluyan, D. Casadei.
Renal Transplant Unit, Instituto de Nefrologia Nephrology, Buenos Aires, Argentina.
HCV infection is associated to chronic hepatitis, cirrhosis, hepatic carcinoma and increased incidence of diabetes. Combination of new antiviral drugs have demonstrated utility in liver…
2018 American Transplant Congress
mRNA Transcript Profiling of 3 Genes in Renal Allograft Biopsies (Bx) Improves Accuracy of Antibody-Mediated Rejection (ABMR) Diagnosis in Transplant Recipients Desensitized with IVIG+Rituximab+Immunoglobulin G-Degrading Enzyme of Streptococcus Pyogenes (IdeS)
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Multiple molecular signatures specific to ABMR based on gene expression in renal allograft Bx of transplant recipients were reported. Here we assessed mRNA transcript…
2018 American Transplant Congress
The Role of Donor-Derived Cell-Free DNA in Identification of Injury in Kidney Allografts with Antibody-Mediated Rejection and De Novo DSA
H. Zhang,¹ L. Liu,¹ C. Zheng,² X. Li,¹ Q. Fu,¹ J. Li,¹ Q. Su,¹ H. Huang,¹ M. Ye,² C. Wang.¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; ²BGI-Guangzhou Medical Laboratory, BGI-Shenzhen, Guangzhou, China.
Objectives: To evaluate the capacity of donor-derived cell-free DNA (dd-cfDNA) in the identification of injury in kidney allografts with antibody-mediated rejection and de novo DSA.Methods:…
2018 American Transplant Congress
Outcomes of C4d+ Immunostaining in Heart Transplantation: Is All Immunologic AMR Bad?
M. Rafiei, J. Patel, E. Kransdorf, R. Levine, S. Dimbil, S. Mersola, G. Esmailian, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: Antibody-mediated rejection (AMR) remains a threat to patients (pts) following heart transplant (HTx). C4d immunostaining is one component involved in the diagnosis of AMR…