Articles tagged "Rejection"

2018 American Transplant Congress
Inflammation in Fibrotic Areas (i-IF/TA) Identifies a T Cell-Mediated Rejection Component of IF/TA with Poor Kidney Allograft Outcome
D. Viglietti, O. Aubert, J-.P. Duong Van Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Addressing the etiological heterogeneity of interstitial fibrosis in kidney allografts represents an important challenge to improve long-term transplant outcomes. We investigated the determinants, clinical and…
2018 American Transplant Congress
Respiratory Viral Infections Induces Exosomes and Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, Following Human Lung Transplantation
M. Gunasekaran,¹ S. Bansal,¹ M. Sharma,¹ R. Walia,¹ R. Hachem,² A. Limaye,³ R. Bremner,¹ M. Smith,¹ T. Mohanakumar.¹
¹St. Joseph's Hosp & Med Ctr, Phoenix; ²Washington Univ Sch Med, St. Louis; ³Univ Washington, Seattle.
Respiratory viral infection (RVI) following human lung transplantation (LTx) increases the risk for chronic rejection. We demonstrated that lung transplant recipients (LTxR) with acute and…
2018 American Transplant Congress
Ex Vivo Expanded Regulatory T Cells Combined with Short-Term Costimulation Blockade Prevent Rejection of Vascularized Composite Allografts
B. Oh,¹ G. Furtmüller,¹ M. Grzelak,¹ L. Vuong,² M. Iglesias,¹ M. Fryer,¹ D. Cooney,¹ W. Lee,¹ G. Raimondi,¹ G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins SOM, Baltimore; ²Washington University in St. Louis SOM, St. Louis.
[Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss. Routine clinical application, however, is hampered by the toxicity of long-term maintenance immunosuppression.…
2018 American Transplant Congress
Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation by Blood Expression of Genes Involved in IFN Signaling
M. Matz,¹ Q. Zhang,¹ F. Heinrich,² C. Lorkowski,¹ K. Wu,³ P. Durek,² N. Lachmann,⁴ M-.F. Mashreghi,² K. Budde.¹
¹Nephrology, University Medicine Charité Berlin, Berlin, Germany; ²Drfz, Berlin, Germany; ³Pathology, University Medicine Charité Berlin, Berlin, Germany; ⁴Center For Tumor Medicine, H&I Laboratory, University Medicine Charité Berlin, Berlin, Germany.
Purpose: Antibody-mediated rejection (ABMR) has been recognized as a major cause of graft loss. Early diagnosis and effective treatment are crucial for salvaging grafts undergoing…
2018 American Transplant Congress
Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection
A. Girnita,^1,2 E. Portwood,² P. Brailey,² M. Cuffy,¹ M. Cardi,¹ F. Paterno,¹ T. Diwan,¹ S. Shah,¹ A. Govil,¹ R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²Hoxworth Blood Center, Cincinnati.
Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…
2018 American Transplant Congress
Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation
J. Leung, S. Chandran, F. Vincenti, Q. Tang.
UCSF, San Francisco.
Background: Proinflammatory cytokine IL-6 increases effector/memory T-cells, induces Th17 cells and prevents the induction of Tregs. IL-6 expression in kidney biopsies is elevated during acute…
2018 American Transplant Congress
Application of RNA-Seq Derived Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) to DNA Microarray-Based Gene Expression Datasets
Z. Wang,¹ L. Pan,² Z. Lyu,² P. Liu,³ G. Tseng,³ P. Randhawa.¹
¹Department of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; ³Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Recent years have seen the development of DNA microarray based tools for the diagnosis of TCMR using fresh frozen tissue. This study has accomplished the…
2018 American Transplant Congress
The Influence of Rabbit Antithymocyte Globulin (rATG) Dose on the Incidence of CMV Infection in Kidney Transplant Recipients Receiving No Pharmacological Prophylaxis. A Propensity Score Matched Cohort Analysis
M. Ivani de Paula,^1,2 S. Bae,¹ J. Garonzik-Wang,¹ C. Felipe,² M. Cristelli,² A. Massie,^1,3 J. Medina-Pestana,² D. Segev,^1,3 H. Tedesco Silva J�nior.²
¹Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Nephrology, Hospital do Rim, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; ³Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, Brazil.
rATG has become the agent of choice for induction therapy in sensitized patients and those receiving expanded criteria donors (ECD) allografts. However, the optimal dose…
2018 American Transplant Congress
DSA Plus TCMR Leads to Poor Outcomes in Renal Allograft Recipients and This is Markedly Exacerbated by Non-Adherence
D. Chittka, A. Cherukuri, A. Sharma, R. Mehta, S. Hariharan, D. Rothstein.
Starzl Transplant Institute, University of Pittsburgh, Pittsburgh.
Post-transplant DSA is strongly associated with poor renal allograft outcomes but has limited predictive value. In this prospective study we aimed to risk-stratify patients with…
2018 American Transplant Congress
The Ratio of CTLA4 to Perforin and Granzyme B as a Potential Biomarker of Tolerance in Chimeric Renal Transplant Patients
A. Khalil,¹ A. Chhabra,¹ A. Merchak,¹ L. Kahn,¹ J. Leventhal,² S. Ildstad.¹
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Northwestern University, Chicago, IL.
Background: Thirty-six subjects have been enrolled in a phase II clinical trial aimed to induce tolerance through chimerism. Each subject received FCRx (mPBMC enriched in…