ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2022 American Transplant Congress

    Immune Cell Phenotype of Acute Rejection of Pancreas Allografts by RNA Sequencing Analysis

    C. Hughes, H. Yang, C. Snopkowski, C. Li, D. M. Dadhania, S. Sultan, C. Hartono, M. Suthanthiran, S. V. Seshan, T. Muthukumar

    Weill Cornell Medicine, New York, NY

    *Purpose: Long term survival of pancreas allografts are inferior to kidney allografts. Molecular mechanisms underpinning pancreas allograft rejection and failure have not been explored in…
  • 2022 American Transplant Congress

    Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration

    A. Buxeda1, L. Llinàs-Mallol1, J. Gimeno2, D. Redondo-Pachón1, C. Arias-Cabrales1, C. Burballa1, A. Puche2, M. Pérez-Sáez1, J. Pascual3, M. Crespo1

    1Nephrology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, 2Pathology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, 3Nephrology Department, Hospital Universitario 12 de Octubre. Institute Mar for Medical Research (IMIM), Madrid, Spain

    *Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…
  • 2022 American Transplant Congress

    Donor-Derived Cell-Free DNA (dd-cfDNA) for Assessment of Response After Treatment of Allograft Rejection

    R. Gohh1, J. Klein2, M. Jagadeesan3, V. Rao4, M. Weir5, H. Gilligan6, G. Shekhtman7, N. Agrawal8, Y. Fu9, E. Akalin10

    1Alpert School of Medicine, Brown University, Providence, RI, 2University of Kansas Medical Center, Kansas City, KS, 3George Washington School of Medicine, Washington, DC, 4Medical University of South Carolina, Charleston, SC, 5University of Maryland, Baltimore, MD, 6Massachusetts General Hospital, Boston, MA, 7CareDx Inc., Brisbane, CA, 8CareDx Inc, Brisbane, CA, 9CareDx, Brisbane, CA, 10Montefiore Medical Center, Bronx, NY

    *Purpose: Surveillance of dd-cfDNA after therapy for rejection represents a promising strategy for monitoring post-treatment response. We assessed post-rejection kinetics of dd-cfDNA among kidney transplant…
  • 2022 American Transplant Congress

    The Successful Use of De Novo Belatacept with Reduced Dose Tacrolimus to Mitigate the Risks of Delayed Graft Function in Kidney Transplantation

    E. Siskind1, J. Splinter1, C. Taing1, A. Adekile2, S. Njim1, S. Shah1, R. Plews3, D. Conti4, S. Patel2

    1Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, 2University Medical Center of Southern Nevada, Las Vegas, NV, 3Center for Transplantation, Albany Medical Center, Albany, NY, 4Albany Medical Center, Albany, NY

    *Purpose: The new kidney allocation system has caused increased organ travel times and therefore increased cold ischemia time. Furthermore, the change in the priority to…
  • 2022 American Transplant Congress

    Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles

    I. Sedej1, M. Štalekar2, M. Tušek Žnidarič2, K. Goričar3, N. Kojc4, P. Kogovšek2, V. Dolžan3, M. Lenassi3, M. Arnol1

    1Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, 3Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 4Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    *Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
  • 2022 American Transplant Congress

    Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes

    J. Callemeyn1, B. Lamarthée1, P. Koshy2, T. Debyser3, E. Van Loon1, A. Franken4, T. Van Brussel4, I. Arijs4, D. Lambrechts4, M. Rabant5, A. Senev1, T. Vaulet6, C. Tinel1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, 3Faculty of Medicine, KU Leuven, Leuven, Belgium, 4Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, 5Necker-Enfants Malades Institute, Institut national de la santé et de la recherche médicale (Inserm), Université de Paris, Paris, France, 6ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium

    *Purpose: Rejection of the kidney allograft is hallmarked by the accumulation of inflammatory cells within the renal architecture, leading to microvascular or tubulointerstitial inflammation. However,…
  • 2022 American Transplant Congress

    Parainfluenza Type 3 Infection in Solid Organ Transplant Recipients

    G. Motoa1, M. A. Mendoza1, M. Raja1, J. Simkins2, S. Anjan2, E. Martin2, A. Phancao2, N. Sinha2, L. Abbo1, G. Guerra2, Y. Natori2

    1University of Miami/Jackson Memorial Hospital, Miami, FL, 2Miami Transplant Institute – University of Miami, Miami, FL

    *Purpose: Respiratory viral infection, including COVID-19, causes significant morbidity and mortality in solid organ transplant recipients (SOTR), however, the data of parainfluenza virus (PIV) type…
  • 2022 American Transplant Congress

    Development and Validation of a Medication Safety Dashboard in Veteran Transplant Recipients: Preliminary Results of a Multicenter Cluster-Randomized Controlled Clinical Trial

    D. Taber1, R. Felkner2, K. Rife3, D. Cooney3, S. Laforest3, E. Santa4, N. Super5, C. Hall6, T. Goddard1, R. Alexander1

    1MUSC, Charleston, SC, 2Madison VA, Madison, WI, 3Cleveland VA, Cleveland, OH, 4Atlanta VA, Atlanta, GA, 5Chicago VA, Chicago, IL, 6Charleston VA, Charleston, SC

    *Purpose: In organ transplant, med errors, adverse drug events, and nonadherence lead to increased healthcare utilization and graft loss. Veterans with transplants are a high-risk…
  • 2022 American Transplant Congress

    Accepting Rejection in Liver Transplant Recipients Requiring Renal Replacement Therapy: A Practice Paradigm

    S. Farghaly1, T. Sparkes1, B. Masters1, A. Haririan2, N. Jakhete3, R. N. Barth4, D. Maluf5, S. Freedman1

    1Pharmacy, University of Maryland Medical Center, Baltimore, MD, 2Nephrology, University of Maryland Medical Center, Baltimore, MD, 3Hepatology, University of Maryland Medical Center, Baltimore, MD, 4Transplant Surgery, University of Chicago Medical Center, Chicago, IL, 5Transplant Surgery, University of Maryland Medical Center, Baltimore, MD

    *Purpose: The purpose of this study is to evaluate rejection outcomes in those requiring renal replacement therapy (RRT) after liver transplant.*Methods: This was a single…
  • 2022 American Transplant Congress

    Place Based Risk for Early Rejection in Lung Transplant

    W. M. Tsuang1, X. Wang2, J. Curtis3

    1Respiratory Institute, Cleveland Clinic, Cleveland, OH, 2Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 3Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH

    *Purpose: Within 5 years after lung transplant (LT), half of recipients have lost 20% or more of lung function. Despite a consistent link between social…
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