Articles tagged "Rejection"

2020 American Transplant Congress
Liver Transplant Recipients with High DSA at Time of Transplant Do Not Have Increased Rejection or Mortality
A. Demirag¹, B. Rawashdeh¹, S. L. Lennon¹, S. Pelletier¹, J. Iezzoni², K. Khutsisvhili³, S. Shumilina¹, K. Chittum¹, J. Oberholzer¹, P. Lobo⁴
¹Department of Surgery, University of Virginia Medical Cener, Charlottesville, VA, ²Department of Pathology, University of Virginia Medical Cener, Charlottesville, VA, ³Histocompatibility Laboratory, University of Virginia Medical Cener, Charlottesville, VA, ⁴Department of Medicine, University of Virginia Medical Cener, Charlottesville, VA
*Purpose: Currently, there is controversy regarding transplanting livers in setting of high HLA-class ll DSA especially since prior studies demonstrated enhanced acute rejections in this…
2020 American Transplant Congress
A Nonhuman Primate Model of Intestinal Transplantation – Technical Aspects and Early Outcomes
R. Schmitz¹, J. Yoon¹, M. Song¹, E. Jelly², A. P. Wax², S. J. Knechtle¹, D. L. Sudan¹, J. Kwun¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Biomedical Engineering, Duke University, Durham, NC
*Purpose: Intestinal transplantation (IT) is the treatment of choice for patients with irreversible intestinal failure that experience complications from total parenteral nutrition. Long-term outcomes after…
2020 American Transplant Congress
Low Diagnostic Yield of Protocol Allograft Biopsy Performed During DGF in Deceased Donor Kidney Transplant Recipients Treated with Induction and Standard-Dose CNI-Based Maintenance
E. Favi¹, A. James², M. Ferraresso¹, R. Cacciola³
¹Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ²Renal Transplantation, Royal London Hospital, London, United Kingdom, ³HBP and Transplant Unit, Tor Vergata University, Rome, Italy
*Purpose: DGF after kidney transplantation (KTx) has been associated with an increased risk of rejection. For this reason, clinical guideline recommends weekly allograft biospy (Bx)…
2020 American Transplant Congress
Cost-Effectiveness of Protocol Biopsies in Kidney Transplantation
C. M. Puttarajappa, S. Hariharan, K. J. Smith
Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: To perform an economic evaluation of protocol biopsies in kidney transplantation*Methods: We used a Markov decision analytical model (Figure 1) to compare the following…
2020 American Transplant Congress
Hepatitis C-Infected Donors and Hepatitis C-Infected Recipients: Analysis of Renal Transplant Outcomes
H. Crossman¹, M. Tavakol², C. Freise², P. Chin-Hong³
¹Internal Medicine Residency Program, UCSF, San Francisco, CA, ²Surgery, UCSF, San Francisco, CA, ³Infectious Disease, UCSF, San Francisco, CA
*Purpose: Increased utilization of hepatitis C virus infected organs could reduce the supply demand mismatch in organ transplantation. At this time, there is little data…
2020 American Transplant Congress
Combined Phenotyping to Identify Kidney Transplants at Greatest Risk after Subclinical Acute Rejection
S. Park¹, R. Heilman², E. Poggio³, D. Taber⁴, L. Zhao¹, K. Guo¹, S. Kurian⁵, C. Rebello¹, S. Brietigam¹, M. Abecassis⁶, J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Mayo Clinic, Scottsdale, AZ, ³Cleveland Clinic, Cleveland, OH, ⁴MUSC, Charleston, SC, ⁵Scripps, La Jolla, CA, ⁶University of Arizona, Tucson, AZ
*Purpose: We hypothesize that the combination of protocol biopsy histology and gene expression profiles (GEP) for subclinical acute rejection (subAR) in the blood will improve…
2020 American Transplant Congress
Changes in Gut Microbiota and Acute Rejection after Kidney Transplantation
H. Cho¹, J. Kim², H. Kim², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, H. Lee²
¹Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc. Seoul National University, Seoul, Korea, Republic of, ⁵Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea, Republic of
*Purpose: Kidney transplantation (KT) is the best treatment for end-stage renal disease. Although rejection is a normal immune response of the body to a foreign…
2020 American Transplant Congress
Early Impact of Interleukin-6 Blockade on the Distribution of Peripheral Blood Immune Cell Subpopulations – 3-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection
K. A. Doberer¹, G. A. Boehmig¹, M. Streitz², S. Schlickeiser², F. Bauernfeind¹, A. Spittler³, B. Jilma⁴, F. Eskandary¹, E. Chong⁵, S. Schranz⁴, K. Budde⁶, M. Dürr⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Berlin, Germany, ³Center of Translational Research, Medical University of Vienna, Vienna, Austria, ⁴Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ⁵Vitaeris Inc., Vancouver, BC, Canada, ⁶Division of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Interleukin-6 (IL-6) is considered to play a critical role within the multifacted pathophysiological process of antibody-mediated rejection (ABMR), including modulation of regulatory T cells…
2020 American Transplant Congress
Impact of Statin Intensity on the Development of Cardiac Allograft Vasculopathy
K. Goehring¹, W. Kuan¹, A. Sieg¹, K. L. Dawson¹, A. R. Kolodziej²
¹Department of Pharmacy, University of Kentucky HealthCare, Lexington, KY, ²Gill Heart and Vascular Institute, University of Kentucky HealthCare, Lexington, KY
*Purpose: This study aims to examine the efficacy of high-intensity statin therapy compared to low-intensity, moderate-intensity, or no statins at preventing cardiac allograft vasculopathy (CAV)…
2020 American Transplant Congress
A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data
J. Vetter¹, A. Heinzel², C. Aschauer², R. Reindl-Schwaighofer², K. Jelencsics², K. Hu², R. Oberbauer², S. Winkler¹, S. Schaller¹
¹Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, ²Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
*Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…