ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2020 American Transplant Congress

    Rabbit Anti-Thymocyte Globulin versus Anti-T Lymphocyte Globulin Rescue Therapies in Delayed Graft Function after Kidney Transplantation from Donors after Cardiac Death

    H. Yang1, Y. Shi2, X. Li1, C. Long1, H. Li3, Z. Wang3

    1Department of Organ Transplantation, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, China, 2Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Delayed graft function (DGF) is common in recipients of kidney transplants from donation after cardiac death (DCD) donors, induction therapy with monoclonal or polyclonal…
  • 2020 American Transplant Congress

    Stanford Integrated Psychosocial Assessment for Transplant Predicts Immunosuppression Non-Adherence after Liver Transplantation

    S. Deutsch-Link1, E. Weinberg2, M. McDougal3, L. Jones4, T. Bitterman2, M. Serper2

    1Medicine, University of Pennsylvania, Philadelphia, PA, 2Gastroenterology & Hepatology, University of Pennsylvania, Philadelphia, PA, 3Drexel University, Philadelphia, PA, 4PCOM, Philadelphia, PA

    *Purpose: Patients with end-stage liver disease presenting for liver transplant (LT) evaluation have a high burden of psychosocial comorbidities. The Stanford Integrated Psychosocial Assessment for…
  • 2020 American Transplant Congress

    The Art Rather Than the Science of Non-HLA Antibody Mediated Rejection in Heart Transplantation: A Single Center Experience

    A. Alam, S. Mckean, R. Patel, V. Darst, H. Zafar, C. Guerrero, M. Askar, T. Sam, S. Hall

    Cardiology, Baylor University Medical Center, Dallas, TX

    *Purpose: The role of non-HLA antibodies (Ab) in HLA-DSA negative antibody mediated rejection (AMR) following heart transplant (HTx) remains largely unknown.*Methods: Retrospective analysis of all…
  • 2020 American Transplant Congress

    The 1st Year Posttransplant Course Reliably Predicts Kidney Graft Survival up to 15 Years Using a Machine Learning-Based Modeling Approach

    W. Gwinner, M. Gietzelt, R. Hanna, A. A. Khalifa, M. Hallensleben, M. Marschollek, H. Haller, J. H. Braesen, I. Scheffner

    Hannover Medical School, Hannover, Germany

    *Purpose: Identification of patients at risk for graft failure can improve individual surveillance and early therapeutic interventions. We used a well-documented patient cohort to establish…
  • 2020 American Transplant Congress

    The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection

    L. Belyayev1, M. Sadat2, J. Kang2, K. Loh2, A. Duttargi2, S. Moturi2, K. Khan2, J. Hawksworth2, C. Matsumoto2, T. Fishbein2, A. Kroemer2

    1Walter Reed National Military Medical Center, Bethesda, MD, 2MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
  • 2020 American Transplant Congress

    De Novo DSA in the Setting of Stable Renal Allograft Function Does Not Impair Long-Term Graft Survival

    R. Knight1, D. T. Nguyen2, E. A. Graviss2, O. Gaber1

    1Surgery, Houston Methodist Hospital, Houston, TX, 2Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX

    *Purpose: To determine the long-term outcome of renal allograft recipients with de novo DSA (dnDSA) in the setting of stable allograft function.*Methods: A single-center review…
  • 2020 American Transplant Congress

    The Histological Picture of Indication Biopsies in the First Days after Renal Transplantation

    E. Van Loon, M. Coemans, A. Senev, D. Kuypers, M. Emonds, M. Naesens

    Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    *Purpose: In preclinical studies, ischemia reperfusion injury and older donor age are associated with renal inflammation in the early phase after transplantation. In human kidney…
  • 2020 American Transplant Congress

    Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients

    P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings

    Natera, Inc., San Carlos, CA

    *Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
  • 2020 American Transplant Congress

    C-Reactive Protein 1-Year Post-Transplant is Associated with Future Development of Coronary Artery Vasculopathy and Rejection in a Pediatric Heart Transplant Cohort

    H. J. Tadros, A. H. Bashir, F. J. Fricker, B. A. Pietra, D. Gupta

    Congenital Heart Center/Pediatrics, University of Florida, Gainesville, FL

    *Purpose: Coronary artery vasculopathy (CAV) is one of the leading causes of mortality beyond 3y post-transplant (OHT). Multiple risk factors are associated with development of…
  • 2020 American Transplant Congress

    Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial

    O. Bestard1, P. Reinke2, F. Bemelman3, O. Viklicky4, M. Koch5, M. Giral6, J. Ruiz7, B. Banas8, E. Crespo1, M. Meneghini1, H. Volk9, J. Grinyo1

    1Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Kidney transplantation Unit, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Kidney transplantation Unit, Amsterdam Medical Centre, Amsterdam, Netherlands, 4Nephrology department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, 5Department of Hepatobiliary Surgery and Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 6Nephrology, Kidney transplantation Unit, Université de Nantes, Nantes, France, 7Nephrology, Hospital Marques de Valdecilla, Santander, Spain, 8Kidney transplantation Unit, University Hospital Regensburg, Regensburg, Germany, 9Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    *Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…
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