Articles tagged "Rejection"

2022 American Transplant Congress
The Roles of Intrarenal B Cells in Regulating Antibody Mediated Rejection After Kidney Transplantation
H. Zhang¹, C. Cavazzoni¹, E. Bechu¹, B. Hanson¹, M. A. Podestà¹, D. Kreisel², A. Alessandrini³, P. Sage¹
¹Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Surgery, Washington University in St Louis, St. Louis, MO, ³Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard, Boston, MA
*Purpose: Alloimmune rejection after kidney transplantation is associated with substantial infiltration of immune cells such as T and B cells in transplanted grafts. However, the…
2022 American Transplant Congress
Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Childrens Hosp, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, ¹³Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
2022 American Transplant Congress
Outcomes of Highly-Sensitized, Virtual and Flow Cross-Match Negative Renal Transplant Recipients: A Retrospective Observational Study
A. Agrawal¹, B. Smith¹, M. Gandhi², C. Schinstock¹
¹Transplant Nephrology, Mayo Clinic, Rochester, MN, ²Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Many highly-sensitized kidney transplant recipients are sensitized from prior transplants, which have been shown to limit graft survival more than pregnancy or blood transfusions.…
2022 American Transplant Congress
Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study
R. Zahr¹, D. Puliyanda², I. Ashoor³, N. Hayde⁴, S. Solomon⁵, R. Engen⁶, L. Harshman⁷, C. Peterson⁸, S. McEwen⁹, A. Jain¹⁰, R. Garro¹¹, A. Mansuri¹², M. Kallash¹³, K. Twombley¹⁴
¹Pediatrics, University of Tennessee Health Science Center, Memphis, TN, ²Cedars-Sinai Med Ctr, West Hollywood, CA, ³Pediatrics, Lousiana State University, New Orleans, LA, ⁴Montefiore Medical Center, Bronx, NY, ⁵The Children's Hospital at Montefiore, New York, NY, ⁶Pediatrics, University of Wisconsin Madison, Madison, WI, ⁷University of Iowa Children's Hospital, Iowa City, IA, ⁸University of Utah, Salt Lake City, UT, ⁹University of Minnesota, Minneapolis, MN, ¹⁰Pediatrics, Wayne State University, Troy, MI, ¹¹Emory University, Atlanta, GA, ¹²Pediatrics, Augusta University, Augusta, GA, ¹³Pediatrics, The Ohio State Univesrity, Columbus, OH, ¹⁴Medical University of South Carolina, Charleston, SC
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…
2022 American Transplant Congress
The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation
K. Evans¹, K. Beermann¹, H. Lee², M. Harris¹, C. W. Frankel³, H. Berry¹, H. Ali³
¹Pharmacy, Duke Health, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC
*Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
2022 American Transplant Congress
Burden of Leukopenia/Neutropenia Among Adult Kidney Transplant Recipients: A Systematic Literature Review of Observational Studies
A. Raval¹, K. Kistler², Y. Tang¹, F. Vincenti³
¹Merck & Co., Inc., Kenilworth, NJ, ²Xcenda, Inc, Carrollton, TX, ³University of California, San Francisco, San Francisco, CA
*Purpose: Leukopenia/neutropenia (L/N) may affect key treatment decisions which could result in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of…
2022 American Transplant Congress
Monitoring of Kidney Allograft Rejection Using Patient-Centric State-of-the-Art Tools – An Approach to Early Diagnosis and Intervention
A. Rizvi¹, A. Gamilla-Crudo², S. A. Hussain³, M. Kueht⁴, J. Fair⁴, M. Mujtaba²
¹Internal Medicine, Nephrology, University of Texas Medical Branch, Galveston, TX, ²University of Texas Medical Branch, Galveston, TX, ³Nephrology, University of Texas Medical Branch, Houston, TX, ⁴Surgery, University of Texas Medical Branch, Galveston, TX
*Purpose: The early detection and timely management of kidney allograft rejection using traditional markers including serum creatinine (SCr) has been inadequate due to lagging response.…
2022 American Transplant Congress
Impact of Varying Levels of Normal Range Baseline Donor Derived Cell Free DNA on Medium-Term Outcomes Following Kidney Transplantation
K. K. Sureshkumar¹, A. Grazier², B. Chopra¹
¹Nephrology, Medicine Institute, Allegheny General Hospital, Pittsburgh, PA, ²Abdominal Transplantation, Allegheny General Hospital, Pittsburgh, PA
*Purpose: Donor derived cell free DNA (dd-cfDNA) is a biomarker with high negative predictive value for ruling out acute rejection (AR) in kidney allografts. Baseline…
2022 American Transplant Congress
Identification Of A Novel Peripheral Blood Six-gene Signature Diagnosing Subclinical Acute Rejection After Renal Transplantation
H. Zhang, Y. Xu, Y. Wang, X. Hu
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Given the insensitivity and nonspecificity of serum creatinine, invasive surveillance biopsies are the main way to detect subclinical acute rejection (subAR) in the absence…
2022 American Transplant Congress
Impact of Target Tacrolimus Levels on BK Polyomavirus DNAemia and Allograft Rejection Among Pediatric Kidney Transplant Recipients
H. Huang¹, P. Winterberg¹, R. George¹, A. Serluco², R. Liverman², I. Yildirim³, R. Garro¹
¹Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ²Children's Healthcare of Atlanta, Atlanta, GA, ³Yale University School of Medicine, New Haven, CT
*Purpose: BK Polyomavirus (BK) DNAemia is a serious and common infectious complication after kidney transplant (KT). We evaluated the impact of targeting lower tacrolimus levels…

« Previous Page
1
…
3
4
5
6
7
…
172
Next Page »