2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…2022 American Transplant Congress
Early Outcomes of Single Dose Eculizumab for Abo-Incompatible Living Donor Renal Transplantation
*Purpose: Use of ABO-incompatible (ABOi) donors increases access to living donor renal transplantation (LDRT). Conventional desensitization with plasmapheresis (PLEX) allows safe ABOi transplantation when pre-transplant…2022 American Transplant Congress
Direct Comparison of Clinical Outcomes with Belatacept-Based Regimens to Calcineurin Inhibitors Among DCD and/or High KDPI Kidney Transplant Recipients
*Purpose: Belatacept, an inhibitor of the T-cell costimulatory pathway, can be used in recipients of Donation after Cardiac Death (DCD) and high Kidney Donor Profile…2022 American Transplant Congress
Month 1 Donor Derived Cell Free DNA Levels Predict Future Kidney Transplant Rejection
1Northwestern University, Chicago, IL, 2Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: The purpose of this study was to determine if donor-derived cell-free DNA (dd-cfDNA) can be used one-month post-transplant to predict later allograft rejection.*Methods: Retrospective…2022 American Transplant Congress
Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft
Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched kidney allografts and are required for rejection of the…2022 American Transplant Congress
Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…2022 American Transplant Congress
A New Algorithm Combining Donor Derived Cell-Free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Natera, Inc., Austin, TX
*Purpose: Donor derived cell-free DNA (dd-cfDNA) has been shown to be associated with allograft rejection, both histological and molecular (JASN, in press). Clinically available dd-cfDNA…2022 American Transplant Congress
Pathological Changes in Kidney Allografts Associated with COVID-19 Vaccination
Christiana Care Health System - Kidney Transplant Program, Newark, DE
*Purpose: The Coronavirus Disease 2019 (COVID-19) pandemic prompted widespread vaccination for the immunosuppressed population starting in January 2021 with minimal information on safety outcomes. The…2022 American Transplant Congress
Co-stimulation Patways Pd-1 (the Programmed Death 1) And Icos (the Inducible T Cell Co-stimulator) In Peripheral Mononuclear Cells Mesured By Flow Cytometry As A Possible Tool In The Follow-up And Diagnosis Of Kidney Transplant Rejection.
Posgrado de Ciencias médicas, Universidad Nacional Autonoma de México, CDMX, Mexico
*Purpose: Currently, the follow-up of KT in the clinic remains the creatinine levels, this is a highly specific, however, without sensitivity to determine diagnosis of…2022 American Transplant Congress
Correlation of Non-HLA Antibodies and Biopsy-Proven Antibody-Mediated Rejection
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Non-HLA antibodies are seen in heart transplantation (HTx), but the clinical significance has not been established. In many cases, non-HLA antibodies are drawn, but…
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