Articles tagged "Rejection"

2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
L. Belyayev¹, M. Sadat², J. Kang², K. Loh², A. Duttargi², S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. Fishbein², A. Kroemer²
¹Walter Reed National Military Medical Center, Bethesda, MD, ²MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
2020 American Transplant Congress
De Novo DSA in the Setting of Stable Renal Allograft Function Does Not Impair Long-Term Graft Survival
R. Knight¹, D. T. Nguyen², E. A. Graviss², O. Gaber¹
¹Surgery, Houston Methodist Hospital, Houston, TX, ²Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: To determine the long-term outcome of renal allograft recipients with de novo DSA (dnDSA) in the setting of stable allograft function.*Methods: A single-center review…
2020 American Transplant Congress
The Histological Picture of Indication Biopsies in the First Days after Renal Transplantation
E. Van Loon, M. Coemans, A. Senev, D. Kuypers, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: In preclinical studies, ischemia reperfusion injury and older donor age are associated with renal inflammation in the early phase after transplantation. In human kidney…
2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings
Natera, Inc., San Carlos, CA
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
2020 American Transplant Congress
C-Reactive Protein 1-Year Post-Transplant is Associated with Future Development of Coronary Artery Vasculopathy and Rejection in a Pediatric Heart Transplant Cohort
H. J. Tadros, A. H. Bashir, F. J. Fricker, B. A. Pietra, D. Gupta
Congenital Heart Center/Pediatrics, University of Florida, Gainesville, FL
*Purpose: Coronary artery vasculopathy (CAV) is one of the leading causes of mortality beyond 3y post-transplant (OHT). Multiple risk factors are associated with development of…
2020 American Transplant Congress
Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial
O. Bestard¹, P. Reinke², F. Bemelman³, O. Viklicky⁴, M. Koch⁵, M. Giral⁶, J. Ruiz⁷, B. Banas⁸, E. Crespo¹, M. Meneghini¹, H. Volk⁹, J. Grinyo¹
¹Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Kidney transplantation Unit, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Kidney transplantation Unit, Amsterdam Medical Centre, Amsterdam, Netherlands, ⁴Nephrology department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, ⁵Department of Hepatobiliary Surgery and Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁶Nephrology, Kidney transplantation Unit, Université de Nantes, Nantes, France, ⁷Nephrology, Hospital Marques de Valdecilla, Santander, Spain, ⁸Kidney transplantation Unit, University Hospital Regensburg, Regensburg, Germany, ⁹Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…
2020 American Transplant Congress
ATHENA – Patient and Allograft Outcome Differences after Kidney Transplantation – Germany vs. France
F. Thaiss¹, C. Sommerer¹, B. Suwelack¹, D. Dragun¹, I. A. Hauser¹, O. Witzke¹, C. Hugo¹, P. Schenker¹, N. Kamar², P. Merville², I. Kroeger³, M. Junge³, B. Nashan¹
¹Athena, Study Group, Germany, ²Athena, Study Group, France, ³Novartis Pharma GmbH, Nürnberg, Germany
*Purpose: In the ATHENA trial [NCT01843348], efficacy and safety of everolimus in combination with tacrolimus [EVR+TAC] or cyclosporine A [EVR+CyA] vs. TAC and mycophenolic acid…
2020 American Transplant Congress
HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation
C. Wiebe¹, D. Pochinco², I. W. Gibson³, J. Ho¹, P. Birk⁴, A. Goldberg⁴, M. Karpinski⁵, J. Shaw⁵, R. N. David⁵, P. W. Nickerson¹
¹Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, ²Shared Health Services, Winnipeg, MB, Canada, ³Pathology, University of Manitoba, Winnipeg, MB, Canada, ⁴Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Medicine, University of Manitoba, Winnipeg, MB, Canada
*Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…
2020 American Transplant Congress
Clinical Significance of C4d and HLA-DSA on Post-Transplant Clinical Outcomes in Kidney Transplant Recipients with Antibody-Mediated Rejection
W. Park, O. Kwon, Y. Kim, J. Paek, K. Jin, S. Park, S. Han
Internal Medicine, Keimyung University School of Medicine, Keimyung University Kidney Institute, Daegu, Korea, Republic of
*Purpose: The clinicopathological diagnosis of rejection after kidney transplantation (KT) was well defined by Banff classification. In the diagnosis of antibody-mediated rejection (AMR), the presence…
2020 American Transplant Congress
Induction Immunosuppression with Thymoglobulin May Improve Graft Outcomes without Increasing a Risk for Infection in Patients Undergoing Liver Transplantation Alone
M. Henry¹, T. Kitajima², J. Konel¹, S. Yeddula², M. Rizzari², K. Collins², D. Moonka², A. Yoshida², M. Abouljoud², S. Nagai³
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Hospital, Detroit, MI, ³Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI
*Purpose: Immunosuppression protocols for liver transplant (LT) vary between institutions and roles of induction immunosuppression in LT remain controversial. The aim of this study was…