Articles tagged "Rejection"

2020 American Transplant Congress
Polyfunctional Cytokine Secreting Th17 Cells Preferentially Infiltrate Murine Renal Allografts with Acute Rejection and Are Associated with Elevated Th17: Treg Ratio
R. Dhital¹, V. Velazquez¹, Q. Zeng², M. Shimamura¹
¹Center for Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Our group has shown that renal transplant patients with acute rejection have elevated blood mRNA RORγt: FOXP3 ratio compared to patients with stable graft…
2020 American Transplant Congress
The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA
M. Coemans¹, A. Senev¹, G. Verbeke², M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
2020 American Transplant Congress
Immune Checkpoint Inhibitor Use in Kidney Transplant Recipients: Rejection Risk, Prevention and Transcriptional Signature in Allograft
N. Murakami¹, G. Reid², A. Weins¹, B. Adam², M. Mengel², L. Riella¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Alberta, Edmonton, AB, Canada
*Purpose: Immune checkpoint inhibitor (ICI) use has changed the landscape of cancer treatment. Several cases of acute rejection in use of ICI have been reported,…
2020 American Transplant Congress
Simultaneously Detection of ddcfDNA in Plasma and Urine Assist to Determine the Type of Rejection in Renal Transplant Patients
D. Cheng¹, F. Liu², H. Liu², T. Jiang², Y. Zhou³, L. Shu², X. Li¹, K. Xie¹, X. Ni¹, J. Chen¹, J. Ge², Z. Liu¹, H. Shi³
¹Jinling Hospital Nanjing University, Nanjing, China, ²AlloDx, Shanghai; Suzhou, China, ³Jiangsu University, Zhenjiang, China
*Purpose: The correct diagnosis and treatment of acute rejection (ABMR and TCMR) are the key to the long-term survival after renal transplantation. Renal biopsy is…
2020 American Transplant Congress
Increased Level of Serum Cholesterol and Apoptosis Together Induces the Development of Liver Fibrosis and Early Allograft Loss
B. H. Ozdemir¹, G. Ozgun¹, E. H. Ayvazoglu Soy², N. Haberal¹, M. Haberal²
¹Pathology, Baskent University, Ankara, Turkey, ²Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey
*Purpose: Hypercholesterolemia (HC) induced oxidative stress known to facilitate apoptosis, steatosis, and TGF-β induced liver injury. Apoptosis, in turn, can trigger inflammation, and fibrosis. Apoptotic…
2020 American Transplant Congress
Clinical Correlations Associated with Development of De Novo Donor-Specific Antibody in the First Year Following Kidney Transplant at a Single Center
J. M. Zimmerer¹, M. Basinger¹, B. A. Ringwald¹, R. Pelletier², A. Rajab¹, A. El-Hinnawi¹, M. Abdel-Rasoul¹, K. Washburn¹, G. L. Bumgardner¹
¹Ohio State University, Columbus, OH, ²Robert Wood Johnson Barnabas Health, New Brunswick, NJ
*Purpose: The development of de novo donor-specific antibody (dnDSA) portends inferior long-term graft survival. This study investigates the short-term clinical correlations associated with dnDSA that…
2020 American Transplant Congress
Predictability of Eplet Mismatch to Acute Rejection in Low Level HLA Antigen Mismatched Kidney Transplantation: Analysis of Korean Organ Transplantation Registry (KOTRY) Data
J. Jeong¹, Y. Hong¹, Y. Park², I. Park³, J. Park⁴, D. Chae⁵, J. Yang⁶, C. Ahn⁵, B. G. Park⁷
¹Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, ²Gachon University, Incheon, Korea, Republic of, ³Ajou University School of Medicine, Suwon, Korea, Republic of, ⁴Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁵Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁶Seoul National University Hospital, Seoul, Korea, Republic of, ⁷Korea University Guro Hospital, Seoul, Korea, Republic of
*Purpose: Epitope matching has been shown to better predict allograft survival and development of de novo donor specific antibodies. In previous study, the number of…
2020 American Transplant Congress
Mass Cytometry-Based Immunoprofiling as a Tool to Predict Rejection in a Large Cohort of Pediatric Transplant Recipients
M. Rao¹, J. T. Harden², M. Lapasaran², C. O. Esquivel³, O. M. Martinez², S. M. Krams²
¹Pediatrics, Stanford University, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Surgery and Pediatrics, Stanford University School of Medicine, Stanford, CA
*Purpose: Rejection remains a serious problem in the pediatric transplant population. Early detection remains a challenge; furthermore, the changes in immune makeup which accompany rejection…
2020 American Transplant Congress
Molecular Profiles of Injury in Heart Transplant Allograft: Relationship to Rejection, Ejection Fraction, and Survival
P. Halloran¹, J. Reeve², &. the INTERHEART Study Group³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: In previous studies we used microarray analysis of gene expression to identify rejection in heart transplant endomyocardial biopsies, and found that this also revealed…
2020 American Transplant Congress
Donor Derived Cell Free DNA (dd-cfDNA) and Gene Expression Signatures of Antibody-Mediated Rejection (ABMR) May Improve Accuracy of ABMR Diagnosis (Dx)
H. Zhang¹, C. C. Nast², E. Huang³, N. Ammerman³, A. A. Vo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Dd-cfDNA has a clinically meaningful association with early Dx of ABMR. Here, we evaluated dd-cfDNA measured prior to for-cause biopsies (Bx), and also measured…