2020 American Transplant Congress
Inflammatory Cytokines Have a Different Effect from One HLA-II Subclass to Another on Human Endothelium
Universite Laval, Quebec, QC, Canada
*Purpose: Development of de novo donor-specific antibodies (DSAs) is associated with antibody-mediated rejection and allograft failure. More particularly, HLA-II DSAs, especially those against DQ are…2020 American Transplant Congress
Association between Response to Rituximab and Risk of Antibody-Mediated Rejection in ABO-Incompatible Living Kidney Transplantation
*Purpose: Owing to limited organ availability, ABO-incompatible living kidney transplantation (ABO-ILKT) has been used extensively. Various forms of preconditioning therapies have been used alone or…2020 American Transplant Congress
B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: T cell reconstitution after lymphoablation in allograft recipients may lead to acute rejection and poor graft outcome. Using a mouse model of heart transplantation…2020 American Transplant Congress
Intimal Arteritis in Association with Microvascular Inflammation Leads to Inferior Graft Survival Regardless DSA
*Purpose: Intimal arteritis belongs between diagnostic criteria of both antibody-mediated rejection (AMR) and T cell-mediated vascular rejection (TCMRV). Patients with intimal arteritis must be assessed…2020 American Transplant Congress
Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…2020 American Transplant Congress
Automated Monitoring of Four Urinary Biomarkers in Routine Surveillance Identifies Patients at Low and High Risk of Renal Allograft Injury
*Purpose: Surveillance renal biopsy data indicate that up to 36% of clinically stable kidney allograft recipients have subclinical rejection, emphasizing the need to implement automated…2020 American Transplant Congress
Operational Tolerance in Kidney Transplant Recipients: Tomogram Transcriptomic Study
*Purpose: TOMOGRAM is a European multicenter study, that aims to identify transcriptomic and genomic signatures of operational tolerance (OT) in a recently identified cohort of…2020 American Transplant Congress
Single Dose Rituximab and Anti-Thymocyte Globulin (ATG) Induction in Hypersensitized Kidney Transplant Recipients
Stanford University School of Medicine, Stanford, CA
*Purpose: Hypersensitized kidney transplant recipients (calculated panel reactive antibody (cPRA) ≥98%) may represent a population at high risk of posttransplant immunologic events. While access to…2020 American Transplant Congress
Association of Congenital Anomalies of the Kidney and Urinary Tract with Urinary Tract Infection and Graft Rejection in Pediatric Kidney Transplant Recipients
Children's Hospital Colorado, Denver, CO
*Purpose: Congenital anomalies of the kidney and urinary tract (CAKUT) are a leading cause of pediatric end-stage renal disease (ESRD). Prior studies have shown an…2020 American Transplant Congress
Torque Teno Virus Level for Risk Stratification of Subclinical Graft Rejection at 12 Months after Kidney Transplantation – An Prospective Observational Cohort Study
Medical University Vienna, Vienna, Austria
*Purpose: Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno…
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