2015 American Transplant Congress
Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function
Transplant Institute, Tulane University, New Orleans, LA.
Historically we had poor understanding of chronic rejection attributing it to hypertension and non-compliance. However in the last decade we have begun to understand the…2015 American Transplant Congress
Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells
Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…2015 American Transplant Congress
Microvascular (MIA) and Interstitial (i) Inflammation Influence Late Death-Censored Graft Failure (DCGF) After Kidney Transplantation
We and others have shown late DCGF is due to ongoing, most often immune, injury. Though there is general agreement that antibody-mediated injury is a…2015 American Transplant Congress
Use of RNA Sequencing for Discovery of Markers of Accommodation in Surveillance Biopsies from Recipients of an ABO-Incompatible Renal Transplant
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…2015 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Enables Accurate Discrimination of Acute Rejection in Kidney Transplant Patients
A common rejection module (CRM) consisting of 11 genes expressed on allograft biopsies was recently shown to be highly accurate to discriminate patients undergoing acute…2015 American Transplant Congress
Pregnancy After Renal Transplantation: Unfavorable Outcomes in Sensitized Patients
Einstein/Montefiore Transplant Center, Bronx.
Background: The objective of our study was to describe pregnancy and allograft outcomes in sensitized kidney recipients in a predominantly Hispanic and African-American population.Methods: This…2015 American Transplant Congress
Histological Analysis in ABO-Compatible and Incompatible Kidney Transplantation By Performing 3-Month and 1-Year Protocol Biopsies
Background. ABO incompatible kidney transplantation (ABO-I KTx) is nowadays a well-established procedure to expand living donor source. Graft and patient survivals of ABO-I KTx were…2015 American Transplant Congress
Donor-Specific Alloantibody After Positive Crossmatch Kidney Transplantation With Eculizumab (EC): Correlation With Transplant Glomerulopathy and Graft Failure
1Mayo Clinic, Rochester, MN; 2Paul Terasaki Foundation, Los Angeles, CA.
Introduction. EC (C5 blockade) reduces the incidence of early clinical acute antibody mediated rejection (AMR) after +XMKTx, but does not prevent chronic AMR. We examined…2015 American Transplant Congress
Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection
University of Chicago, Chicago, IL.
In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…2015 American Transplant Congress
Inhibition of RhoA Pathway-Related Macrophage Functions Abrogates Chronic Rejection of Cardiac Allograft
Objective. Chronic rejection remains the main obstacle in the long-term success of organ transplantation. The long-term survival of allografted hearts is limited by a progressive…
American Transplant Congress abstracts