2015 American Transplant Congress
Potential Urine Protein Biomarkers for Kidney Transplantation Dysfunction Through Quantitative Proteomics
Introduction: Inability to effectively monitor transplant injuries leads to immune and non-immune mediated graft dysfunction. A non-invasive tool to monitor such injuries is an unmet…2015 American Transplant Congress
Deceased Donor HLA Antibody Incompatible Renal Transplantation Without Antibody Removal: High Incidence of Acute Rejection Reduced By T-Cell Depleting Induction Therapy
Aims: Screening for HLA-specific antibodies (Ab) is routine for patients on kidney transplant waiting lists, and HLA antigens to which a patient has detectable Ab…2015 American Transplant Congress
Endosome-Based Activation of Non-Canonical NF-kB Signaling By Membrane Attack Complexes
Using sera from transplant patients with high-titer panel reactive antibody (PRA), we previously described a model for studying the effects of alloantibody binding and complement…2015 American Transplant Congress
Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation
Houston Methodist Hospital, Houston, TX.
It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…2015 American Transplant Congress
Late Rejection in Pediatric Heart Transplantation: The Importance of Medical Adherence
Division of Pediatric Cardiology, Columbia University, New York, NY.
While the incidence of early rejection (<1 yr post-transplant) after pediatric heart transplant (HT) has decreased, late rejection (> 1 yr post-transplant) remains a constant…2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…2015 American Transplant Congress
Intra-Renal Cytokine Measurement Detected During Kidney Allograft Biopsies Portend Severity of Histological Injury
Division of Nephrology, University of Washington, Seattle, WA.
Histological changes observed on renal allograft biopsies, although considered the current standard for evaluation of allograft injury, lack specificity and disease activity assessment. We devised…2015 American Transplant Congress
Outcomes of Kidney Transplantation of ABO- and Crossmatch-Incompatible Recipient-Donor Pairs Entered in Kidney Paired Donation Program
Transplantation Medicine, Weill Cornell Medical Center, New York, NY.
Kidney Paired Donation (KPD) enables ABO-incompatible (ABOI) and crossmatch-incompatible (XMI) patients to undergo transplantation using a 'more compatible' donor. Identification of factors that predict early…2015 American Transplant Congress
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR
Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.
Aim: Antibody-mediated rejection (AMR) persists as a major issue affecting solid organ transplants. The purpose of this study was to investigate the proximal signaling events…2015 American Transplant Congress
Changes in Donor Specific Antibodies (DSA) First Year After Kidney Transplant (KTX): Implications for Graft Histology and Survival
Introduction. De novo DSA post-KTx is associated with high risk of chronic antibody mediated rejection (cAMR) and reduced graft survival. DSA changes during first year…
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