Articles tagged "Rejection"

2015 American Transplant Congress
Husband to Wife Renal Transplants Are Associated With a Higher Risk of Early Antibody Mediated Rejection and Transplant Glomerulopathy
H. Sawhney, M. Willicombe, P. Brookes, E. Santos, D. Taube.
Renal and Transplant Centre, Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England, United Kingdom.
Patients with a low level preformed donor specific antibodies [DSA] with a negative FCXM/CDC cross match are at high risk of antibody mediated rejection [AMR]…
2015 American Transplant Congress
Clinical and Biochemical Results of BK Virus Nephropathy in Kidney Allograft Recipients
B. Canbakan,¹ I. Akdağ,¹ ö. Merhametsiz,¹ ö. Yayar,² E. Oğuz,¹ M. Kiliç,³ D. Ayli.¹
¹Nephrology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; ²Nephrology, Atatürk Training and Research Hospital, Ankara, Turkey; ³General Surgery, Atatürk Training and Research Hospital, Ankara, Turkey.
BK virus (BKV) nephropathy has emerged as a significant cause of graft dysfuction in kidney allograft recipients after using powerful immunosupressive treatment protocols in recent…
2015 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
G. Furtmüller,¹ N. Crane,² R. Luthra,² E. Swanson,¹ H.-T. Cheng,¹ B. Oh,¹ M. Fryer,¹ E. Elster,² W. Lee,¹ G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD.
Purpose: To evaluate imaging modalities such as 3CCD and infrared (IR) technology as a means of non-invasive monitoring of graft acceptance and rejection in the…
2015 American Transplant Congress
Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model
T. Kwan,^1,2 S. Chadban,^1,2 J. Ma,^1,2 S. Bao,^2,3 S. Alexander,^2,4 H. Wu.^1,2
¹Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; ²Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; ³Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; ⁴Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…
2015 American Transplant Congress
The Immunosuppressive Effects of Erythropoietin Do Not Confer Lower Rates of Acute Rejection in Post Kidney Transplant Recipients Receiving Darbepoetin
B. Fischbach,¹ S. Gonzalez,¹ A. Yango,¹ A. Chandrakantan,² A. Rajagopal,² K. Rice,² L. Melton,² Y. Barri,² M. Saim,² N. Onaca,¹ R. Ruiz,¹ M. Levy,¹ G. Klintmalm.²
¹Simmons Transplant Institute, Baylor All Saints Medical Center, Fort Worth, TX; ²Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.
Background: The correction of anemia has been associated with improved kidney allograft outcomes. Recently, erythropoietin was shown to directly suppress alloreactive human T-cells by inhibiting…
2015 American Transplant Congress
Changes in Health Related Quality of Life (HRQOL) in Pediatric Liver Transplant (LT) Recipients During Protocolized Immunosuppression Withdrawal (ISW): The iWITH Trial
S. Mohammad,¹ S. Sundaram,² V. Venkat,³ M. Martinez,⁴ J. Lopez,⁵ J. Magee,⁵ E. Alonso,¹ S. Feng.⁶
¹Northwestern U, Chicago; ²U of Colorado, Aurora; ³U of Pittsburgh, Pittsburgh; ⁴Columbia U., New York; ⁵U of Michigan, Ann Arbor; ⁶UCSF, San francisco.
ISW may limit medication-related comorbidities but intensive monitoring and unexpected rejection episodes may compromise HRQOL. We studied longitudinal HRQOL in pediatric LT recipients undergoing ISW…
2015 American Transplant Congress
Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury
D. Viglietti,^1,2 C. Bentlejewski,³ J.-P. Duong van Huyen,^4,2 D. Vernerey,^5,2 O. Aubert,² J. Verine,¹ X. Jouven,² C. Legendre,⁴ D. Glotz,¹ A. Loupy,^2,4 A. Zeevi,³ C. Lefaucheur.^1,2
¹Saint-Louis Hospital, Paris, France; ²Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; ³University of Pittsburgh Medical Center, Pittsburgh; ⁴Necker Hospital, Paris, France; ⁵CHRU de Besançon, Besançon, France.
Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
2015 American Transplant Congress
Inhibition of Endogenous Memory CD8 T Cell Infiltration Into Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage Is Required to Promote Long-Term Graft Survival
N. Kohei,¹ H. Tsuda,^1,3 T. Tanaka,^1,4 S. Iida,² T. Abe,³ C. Su,¹ D. Kish,¹ K. Tanabe,² A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology Kidney Center, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Sapporo Medical University, Sapporo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
M. Matz,¹ K. Fabritius,¹ C. Lorkowski,¹ M. Dürr,¹ J. Gaedeke,¹ P. Durek,² J. Grün,² A. Goestemeyer,¹ F. Bachmann,¹ K. Wu,¹ B. Rudolph,¹ U. Weber,¹ C. Haftmann,² N. Unterwalder,³ N. Lachmann,¹ A. Radbruch,² H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹University Medicine Charité, Berlin, Germany; ²German Rheumatism Research Centre, Berlin, Germany; ³Labor Berlin GmbH, Berlin, Germany.
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…
2015 American Transplant Congress
Prospects of Differentiating T-Cell Mediated Rejection (TCMR) from BK Virus Nephropathy (BKVN) Using Next Generation Sequencing (NGS) of the T-Cell Receptor (TCR)
G. Zeng, Y. Huang, P. Randhawa.
Pathology, University of Pittsburgh, Pittsburgh, PA.
Histopathology cannot determine whether T-cell infiltrates in renal allograft biopsies recognize donor HLA or BKV antigens. The ability of a T-cell to respond in an…