ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Patient Self-Reported Adherence to and Perceptions Towards Immunosuppressive Medications at the Outpatient Renal Transplant Clinic at St. Joseph's Healthcare Hamilton (SJHH)

    K. Kak,1 C. Burger,1 D. Treleaven,2 C. Wallace.1

    1Pharmacy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; 2Medicine, McMaster University, Hamilton, ON, Canada.

    Objectives To gain insight into the immunosuppressant adherence of patients followed by the Outpatient Renal Transplant Clinic at St. Joseph's Healthcare Hamilton (SJHH) and to…
  • 2015 American Transplant Congress

    OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)

    F. Schena,1 C. Curci,1 F. Sallustio,1 M. Trpevski,1 G. De Palma,1 M. Fiorentino,2 M. Rossini,2 M. Quaglia,3 E. Bozzola,3 S. Zanini,4 L. Furian,4 A. Toscano,5 E. Gallo,6 L. Gesualdo,2 P. Stratta,3 P. Rigotti,4 F. Citterio,5 L. Biancone.6

    1C.A.R.S.O. Consortium, Valenzano, Italy; 2University of Bari, Bari, Italy; 3A.O.U. Maggiore della Carità, Novara, Italy; 4University of Padova, Padua, Italy; 5Cattolica Sacro Cuore University, Rome, Italy; 6University of Torino, Turine, Italy.

    Introduction:TCMR is characterized by the reduction of vessel lumen with marked intimal thickening, fibrous hyperplasia and a strong component of leukocyte infiltrate. Aim of our…
  • 2015 American Transplant Congress

    Impact of Subclinical Rejection (SCR) and Acute Clinical (ACR) in Renal Transplant Recipients

    R. Mehta, P. Sood, A. Cherukuri, S. Chen, G. Mour, C. Wu, N. Shah, C. Puttarajappa, P. Randhawa, A. Tevar, S. Hariharan.

    University of Pittsburgh Medical Center, Pittsburgh, PA.

    The importance of diagnosing subclinical rejection and its short and long term impact remains controversial.We prospectively evaluated 296 patients who had a kidney transplant at…
  • 2015 American Transplant Congress

    Noninvasive Diagnostic and Predictive Value in Renal Transplant Recipients by Measurement of Urine BCA-1

    D. Chen, J. Chen, W. Peng.

    Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Nephropathy, Zhejiang Province; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese.

    ObjectiveTo investigate the relationship between early-stage renal acute rejection and the level of BCA-1 in urine, explore the diagnostic value and noninvasive monitoring in early…
  • 2015 American Transplant Congress

    Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival

    F. Cosio,1 C. Schinstock,1 M. Stegall.2

    1Medicine, Mayo Clinic, Rochester, MN; 2Surgery, Mayo Clinic, Rochester, MN.

    Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…
  • 2015 American Transplant Congress

    DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection

    J. Wedel, S. Bruneau, K. Liu, N. Kochupurakkal, M. Laplante, D. Briscoe.

    Transplant Research Program, Boston Children's Hospital, Boston, MA.

    DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…
  • 2015 American Transplant Congress

    Donor Specific Expansion of Regulatory T-Cells Was Associated With Allograft Tolerance Induced By Transient Mixed Chimerism in Nonhuman Primates

    K. Hotta, A. Aoyama, T. Ohura, M. Tonsho, Y. Yamada, J. Allan, J. Madsen, B. Cosimi, G. Benichou, T. Kawai.

    Transplant Center, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported successful induction of solid organ allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Since these recipients achieved…
  • 2015 American Transplant Congress

    CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs

    A. Kroemer,1,2 M. Lantow,1 E. Eggenhofer,1 M. Sabet-Baktach,1 P. Renner,1 H. Schlitt,1 E. Geissler.1

    1Department of Surgery, University Hospital Regensburg, Regensburg, Germany; 2Georgetown Transplant Institute, Washington, DC.

    The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…
  • 2015 American Transplant Congress

    Depression of Complement Regulatory Factors in Human and Rat Renal Grafts in Association With Progress of Acute Cellular Rejection

    K. Yamanaka,1 T. Kato,1 Y. Kakuta,1 T. Abe,1 R. Imamura,1 A. Maeda,2 S. Miyagawa,2 N. Nonomura.1

    1Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Organ Transplantation, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

    Introduction and ObjectiveIt is commonly known that complements play important roles in antibody mediated rejection in renal transplantation. However, the association of complements with progression…
  • 2015 American Transplant Congress

    The Impact of Microcirculation Inflammation in Predicting Treatment Response for Late Onset Antibody Mediated Rejection

    J. Lee,1 J. Lee,1 B. Lim,2 B. Kim,3 M. Ju,1 M. Kim,1 S. Kim,1 Y. Kim,1 H. Jeong,2 K. Park,4 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Pathology, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; 4Department of Surgery, CHA Bundang Medical Center, Bundang, Republic of Korea.

    BackgroundThere have been marked advances of immunosuppression. However, management of late onset antibody-mediated rejection (AMR) after 6 months is still challenging. Despite important diagnostic and…
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