ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Elevated ST2 Levels Are Associated With Increased Risk of Antibody Mediated Rejection in Heart Transplant Recipients

    A. Grupper,1 S. Kushwaha,1 O. Abou Ezzeddine,1 J. Geske,2 W. Kremers,2 B. Edwards,1 N. Pereira.1

    1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN; 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.

    Objective: Serum ST2, a member of the interleukin (IL) 1 receptor family, is a novel biomarker that reflects cardiac remodeling and fibrosis and is associated…
  • 2015 American Transplant Congress

    Propensity Score-Weighted Analysis of Induction Therapies in Live Donor Kidney Transplantation in Modern Immunosuppression Era

    B. Tanriover,1 S. Zhang,2 M. MacConmara.3

    1Medicine, UTSW, Dallas, TX; 2Clinical Sciences, UTSW, Dallas, TX; 3Surgery, UTSW, Dallas, TX.

    Background: Induction therapy with interleukin-2 receptor antagonist (IL2-RA) is recommended as a first line agent in living donor renal transplantation (LRT). However, use of IL2-RA…
  • 2015 American Transplant Congress

    Sevoflurane Based Anesthesia in Recipients Reduces 2 Year Acute Rejection in Living Donor Kidney Transplantation. Results from the VAPOR-Trial

    G. Nieuwenhuijs-Moeke,1 V. Nieuwenhuijs,2 M. Seelen,3 R. Ploeg,2 H. Leuvenink,2 M. Struys.1

    1Anesthesiology, University Medical Center, Groningen, Netherlands; 2Surgery, University Medical Center, Groningen, Netherlands; 3Nephrology, University Medical Center, Groningen, Netherlands.

    IntroductionVolatile anesthetic agents like sevoflurane may protect against the ischemia and reperfusion injury (IRI) that is inevitable part of organ donation and transplantation. It is…
  • 2015 American Transplant Congress

    Delayed Graft Function (DGF) in Kidney Transplant Recipients (KTRs) Is Associated With Early Allograft Inflammation and Progressive Fibrosis Within 3 Months

    A. Cherukuri, R. Mehta, P. Sood, S. Chen, G. Mour, A. Tevar, P. Randhava, S. Hariharan.

    University of Pittsburgh, Pittsburgh.

    DGF had been shown to be deleterious to KTR outcomes. Analysis of histological progression in KTRs with DGF was previously not attempted. In this prospective…
  • 2015 American Transplant Congress

    Impact of HLA Antibody Monitoring After Kidney Transplantation

    S. Rao,1 M. Ghanta,1 H. Parekh,2 A. Gillespie,1 I. Lee,1 S. Geier,2 K. Lau,3 S. Karhadkar,3 A. Di Carlo,3 S. Constantinescu.1

    1Nephrology, Temple Univesity School of Medicine, Philadelphia, PA; 2Pathology, Temple Univesity School of Medicine, Philadelphia, PA; 3Surgery, Temple Univesity School of Medicine, Philadelphia, PA.

    The impact of donor specific antibodies (DSA) and optimal therapeutic intervention for DSA in kidney transplant (KT) recipients has been reported with variable results. We…
  • 2015 American Transplant Congress

    The Effect of Preformed and De Novo Donor-Specific Antibodies (DSA) in Acute Rejection (AR) After Liver Transplantation (LTX)

    M. Koch,1 M. Runnebaum,1 M. Goebel,2 H. Thude,1 M. Sterneck,1 M. Marget,2 B. Nashan.1

    1Hepatobiliary Surgery and Transplantation, University Medical Centre, Hamburg, Germany; 2HLA-Laboratory, University Medical Centre, Hamburg, Germany.

    BACKGROUND: The role of preformed and den novo formed DSA in LTX is not fully revealed. The aim of our study was to determine if…
  • 2015 American Transplant Congress

    Current Status of US Intestinal and Multivisceral Transplantation: An Analysis of the UNOS Intestine Transplant Registry

    J. Cai,1 A. Qing,2 G. Wu,3 M. Everly,1 P. Terasaki.1

    1Terasaki Foundation Lab, Los Angeles, CA; 2Lincoln High School, Stockton, CA; 3The 4th Military Medical University, Xi-An, China.

    The purpose of this study is to analyze the current status of US intestinal transplantation (IT). As of 9/19/2014, 2441 IT have been performed in…
  • 2015 American Transplant Congress

    Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology

    J. Blatter,1 F. White,2 A. Faro,1 P. Michelson,1 U. Boston,3 P. Eghtesady,3 S. Sweet.1

    1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; 2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; 3Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.

    Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
  • 2015 American Transplant Congress

    mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia

    I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.

    Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany.

    ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…
  • 2015 American Transplant Congress

    Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients

    M. Crespo,1 D. Redondo,1 J. Yelamos,2 A. Muntasell,2 M. Pérez-Sáez,1 M. Lopez-Montañes,3 C. Garcia,4 A. Torío,5 J. Hernandez,4 M. Mir,1 M. Lopez-Botet,3 J. Pascual.1

    1Nephrology, Hospital del Mar, Barcelona, Spain; 2Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; 3Grup de Investigacio en Immunologia, Universitat Pompeu Fabra, Barcelona, Spain; 4Laboratori de Referencia de Catalunya, Barcelona, Spain; 5Immunology Unit, Hospital de Alicante, Alicante, Spain.

    Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
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