ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    CXCR4-SDF1α Blockade Reduces the Severity of Murine Heart Allograft Rejection

    X. Wang,1 J. Fu,1 B. Wilde,1 L. Jing,1 J. Zhu,1 A. Kribben,1 O. Witzke,1 A. Hoerning.2,3

    1Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; 2Department of Pediatrics II, University Hospital Essen, University Duisburg-Essen, Essen, Germany; 3Department of Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen, Erlangen, Germany.

    Introduction: The interaction of the CXCR4/SDF1α axis plays a critical role in the retention of hematopoietic stem cells in bone marrow. We hypothesized that the…
  • 2015 American Transplant Congress

    Transplant Glomerulitis in Allograft Kidneys Is Correlated With Antibody-Mediated Rejection

    W. Xu, T. Deng.

    Department of Pathology, MedStar Georgetown University Hospital and Washington Hospital Center, Washington.

    Background: Antibody-mediated rejection manifests with glomerular and peritubular capillary inflammation, transplant glomerulopathy. Transplant glomerulitis is an increasingly recognized lesion in renal transplant biopsies, characterized by…
  • 2015 American Transplant Congress

    DSA Detected by ELISA-PRA Is Associated With High Risk for Development of AMR in Stable Kidney Transplant Recipients

    D. Lee,1 J. Kim,2 B. Kim,3 M. Chun,4 I. Kim.5

    1Medicine, Division of Nephrology, Maryknoll General Hospital, Busan, Republic of Korea; 2Surgery, Maryknoll General Hospital, Busan, Republic of Korea; 3Laboratory Medicine, Maryknoll General Hospital, Busan, Republic of Korea; 4Pathology, Maryknoll General Hospital, Busan, Republic of Korea; 5Urology, Maryknoll General Hospital, Busan, Republic of Korea.

    Background: Donor specific anti-HLA antibodies (DSA) are a major cause of antibody mediated rejection (AMR) and allograft loss, determining how to monitor patients for DSA…
  • 2015 American Transplant Congress

    The Impact of Baseline and Follow-Up Social Adaptability Index Scores on Outcomes in Kidney Transplantation

    D. Taber, M. Hamedi, M. Gebregziabher, T. Srinivas, K. Chavin, L. Egede, P. Baliga.

    MUSC, Charleston, SC.

    Globally, socioeconomic status (SES) is a significant determinant of health outcomes, with the social adaptability index (SAI) representing a quantifiable and validated surrogate of SES.…
  • 2015 American Transplant Congress

    Renal Allografts Demonstrate Improved Pathology After Belatacept Therapy

    T. Saavedra,1 O. Opara,1 R. McLoughlin,1 B. Philosophe,2 C. Drachenberg,1 M. Weir,1 S. Bartlett,1 D. Leeser,1 J. Bromberg,1 R. Barth.1

    1University of Maryland School of Medicine, Baltimore; 2Johns Hopkins University, Baltimore.

    Belatacept provides immunosuppression via costimulation blockade and has been associated with improved renal function compared to calcineurin inhibitor based therapies. We developed the Maryland Aggregate…
  • 2015 American Transplant Congress

    Urinary Cell-Free DNA Is a Sensitive Marker of Early Renal Transplant Injury

    T. Sigdel, T. Tran, S.-C. Hsieh, M. Sarwal.

    Surgery, UC San Francisco, San Francisco, CA.

    Introduction:Circulating donor-derived cell-free DNA (dd-cfDNA) has been reported as a surrogate of transplant injury in the blood but requires expensive donor and recipient DNA sequencing.Method:…
  • 2015 American Transplant Congress

    Which Place of Pancreas Graft Biopsy in the Management of Pancreas Transplant Recipients?

    F. Buron, M. Rabeyrin, O. Rouvière, S. Reffet, C. Chauvet, O. Thaunat, M. Brunet, R. Cahen, S. Daoud, C. Pouteil-Noble, R. Codas, L. Badet, E. Morelon.

    Hospices civils de Lyon, Lyon, France.

    Introduction.Rejection or autoimmune recurrence is often difficult to diagnose in the field of pancreas transplantation. The place of pancreas graft biopsy in the management of…
  • 2015 American Transplant Congress

    Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates

    K. Hotta, A. Aoyama, P. Putheti, Y. Yamada, T. Ohura, R. Colvin, B. Cosimi, G. Benichou, T. Strom, T. Kawai.

    Transplant Center, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…
  • 2015 American Transplant Congress

    Prognostic Relevance of Rejection Episodes Detected Within the First 3 Weeks After Kidney Transplantation

    V. Arelin,1 H. Schrem,2 F. Lehner,2 W. Gwinner,1 H. Haller,1 M. Schiffer.1

    1Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Lower Saxony, Germany; 2General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany.

    Background:The relevance of cellular rejection events detected in the early phase after kidney transplantation for graft survival and function remains to be elucidated. Especially the…
  • 2015 American Transplant Congress

    A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity

    Y. Ng, O. Bestard, T. Sigdel, S.-C. Hsieh, T. Tran, M. Sarwal.

    Transplantation Surgery, UC San Francisco, San Francisco, CA.

    Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…
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