ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Non-Invasive Diagnosis of Post Kidney Transplant Complications by Urinary Exosomal mRNA Analysis

    H. Harada,1 T. Murakami,2 C. Yamamoto,2 M. Mitsuhashi.2

    1Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; 2Hitachi Chemical Research Center, Inc., Irvine, CA.

    IntroductionMonitoring of kidney allograft status is important for the graft longevity. Conventional urinary markers are not sensitive and specific enough to diagnose graft injuries so…
  • 2015 American Transplant Congress

    Immunological Characterization of Full Facial Transplant Recipients

    T. Borges,1 J. Azzi,1 S. Tullius,1 A. Chandraker,1 B. Pomahac,2 N. Najafian,1 L. Riella.1

    1Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Plastic Surgery, Boston.

    Background: Despite the skin being considered the most immunogenic of all human tissues, full facial transplantation (FFT) has become a life transforming procedure with encouraging…
  • 2015 American Transplant Congress

    MicroRNA (miR) 144 Dysregulates TGFβ Signaling Cascade and Contributes to Development of BOS Following Human Lung Transplantation

    Z. Xu,1 S. Ramachandran,1 D. Nayak,1 M. Gunasekaran,1 E. Trulock,1 R. Hachem,1 D. Kreisel,1 T. Mohanakumar.1

    1Surgery, Washington Univ Sch Med, St. Louis, MO; 2Medicine, Washington Univ Sch Med, St. Louis, MO.

    Background: Bronchiolitis Obliterans Syndrome (BOS) is characterized by a fibroproliferative cascade that is not amenable to current treatment regimens and remains the major impediment for…
  • 2015 American Transplant Congress

    Chronic Active Antibody Mediated Rejection (cABMR): Treatment, Outcomes and Predictors of Graft Loss in a Large Case Series

    R. Redfield,1 T. Ellis,1 W. Zhong,1 T. Zens,1 M. Rizzari,1 J. Scalea,1 L. Jacobson,1 D. Mandelbrot,1 S. Parajuli,1 B. Muth,1 M. Mohamed,1 S. Panzer,1 B. Astor,1 M. Samaniego,2 D. Kaufman,1 A. Djamali.1

    1University of Wisconsin, Madison, WI; 2University of Michigan, Ann Arbor, MI.

    Background: CABMR is a barrier to long-term kidney allograft survival. There is little information on the treatment and outcomes of kidney transplant recipients with cABMR.Methods:…
  • 2015 American Transplant Congress

    Outcomes of Treatment of Late Antibody-Mediated Rejection in Primary Renal Transplant Recipients – A Single Center Experience

    R. Prashar, A. Patel, K. Venkat.

    Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI.

    Background: Successful reversal of early post-transplant antibody mediated rejection (AMR) is well documented, but data on the results of treatment of late AMR are lacking.…
  • 2015 American Transplant Congress

    Clinical Utility of Allospecific CD154+T-Cells in Children With Liver Or Intestine Transplantation (LTx, ITx)

    K. Soltys, G. Bond, G. Mazariegos, C. Ashokkumar, K. Dirling, L. O'Toole, P. Kachmar, T. Hartle, D. Martin, C. Trautz, R. Sindhi.

    Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Background: Allospecific CD154+T-cytotoxic memory (CD154+TcM) have completed investigational evaluation as predictors of acute cellular rejection in children with LTx or ITx.Purpose: To evaluate CD154+TcM** as…
  • 2015 American Transplant Congress

    Responsiveness to Rituximab, Plasmapheresis and Intravenous Immunoglobulins in Antibody Mediated Rejections After Kidney and Pancreas – Kidney Transplantation

    E. Minué,1 L. León,1 P. Uva,1 A. Dotta,1 J. Walther,1 O. Casanova,1 F. Togniolo,1 O. Guardia,1 M. Rial,1 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina.

    The antibody-mediated rejection (AMR) has become clinically critical because this form of rejection is usually unresponsive to conventional anti-rejection therapy. Therefore, it has been recognized…
  • 2015 American Transplant Congress

    HLA-C, KIR Genotypes and KIR Genotype/HLA –C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation

    K. Park,1 J. Ryu,1 H. Park,3 Y. Kim,2 E.-J. Oh.2

    1Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea; 2Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea; 3Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

    Introduction; Interaction of killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen class-I (HLA-I) regulates NK cytotoxicity and function. NK regulation influences on NK/T cell alloreactivity…
  • 2015 American Transplant Congress

    Post-Transplantation Immunoadsorption Can Be Safely Withheld After ABO-Incompatible Kidney Transplantation

    A. de Weerd,1 M. van Agteren,1 J. Ijzermans,2 W. Weimar,1 M. Betjes.1

    1Nephrology and Kidney Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

    Background: After ABO-incompatible kidney transplantation, postoperative plasma exchange (PE) or immunoadsorption (IA) is performed per protocol or depending on postoperative A/B-titers to prevent acute rejection.…
  • 2015 American Transplant Congress

    Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation

    D. Joo,1,2 J. Lee,3 J. Lee,1,2 J. Lee,1,2 S. Kim,4 D. Han,1,2 M. Ju,1,2 J. Choi,1,2 S. Kim,1,2 M. Kim.1,2

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea; 4Department of Surgery, Wonju Yonsei University College of Medicine, Wonju, Korea.

    Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…
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