Articles tagged "Rejection"

2015 American Transplant Congress
Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model
T. Kwan,^1,2 S. Chadban,^1,2 J. Ma,^1,2 S. Bao,^2,3 S. Alexander,^2,4 H. Wu.^1,2
¹Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; ²Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; ³Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; ⁴Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…
2015 American Transplant Congress
The Clinical Outcome of Plasma Cell-Rich Rejection of Kidney Allograft
J. Hasegawa,¹ K. Honda,² S. Wakai,¹ H. Shirakawa,³ M. Okumi,³ K. Omoto,³ H. Ishida,³ K. Tanabe.³
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Plasma cell-rich rejection (PCRR) is a rare type of allograft rejection characterized by the presence of mature plasma cells. This type of rejection has…
2015 American Transplant Congress
Changes in Health Related Quality of Life (HRQOL) in Pediatric Liver Transplant (LT) Recipients During Protocolized Immunosuppression Withdrawal (ISW): The iWITH Trial
S. Mohammad,¹ S. Sundaram,² V. Venkat,³ M. Martinez,⁴ J. Lopez,⁵ J. Magee,⁵ E. Alonso,¹ S. Feng.⁶
¹Northwestern U, Chicago; ²U of Colorado, Aurora; ³U of Pittsburgh, Pittsburgh; ⁴Columbia U., New York; ⁵U of Michigan, Ann Arbor; ⁶UCSF, San francisco.
ISW may limit medication-related comorbidities but intensive monitoring and unexpected rejection episodes may compromise HRQOL. We studied longitudinal HRQOL in pediatric LT recipients undergoing ISW…
2015 American Transplant Congress
Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury
D. Viglietti,^1,2 C. Bentlejewski,³ J.-P. Duong van Huyen,^4,2 D. Vernerey,^5,2 O. Aubert,² J. Verine,¹ X. Jouven,² C. Legendre,⁴ D. Glotz,¹ A. Loupy,^2,4 A. Zeevi,³ C. Lefaucheur.^1,2
¹Saint-Louis Hospital, Paris, France; ²Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; ³University of Pittsburgh Medical Center, Pittsburgh; ⁴Necker Hospital, Paris, France; ⁵CHRU de Besançon, Besançon, France.
Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
2015 American Transplant Congress
Inhibition of Endogenous Memory CD8 T Cell Infiltration Into Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage Is Required to Promote Long-Term Graft Survival
N. Kohei,¹ H. Tsuda,^1,3 T. Tanaka,^1,4 S. Iida,² T. Abe,³ C. Su,¹ D. Kish,¹ K. Tanabe,² A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology Kidney Center, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Sapporo Medical University, Sapporo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
M. Matz,¹ K. Fabritius,¹ C. Lorkowski,¹ M. Dürr,¹ J. Gaedeke,¹ P. Durek,² J. Grün,² A. Goestemeyer,¹ F. Bachmann,¹ K. Wu,¹ B. Rudolph,¹ U. Weber,¹ C. Haftmann,² N. Unterwalder,³ N. Lachmann,¹ A. Radbruch,² H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹University Medicine Charité, Berlin, Germany; ²German Rheumatism Research Centre, Berlin, Germany; ³Labor Berlin GmbH, Berlin, Germany.
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…
2015 American Transplant Congress
Prospects of Differentiating T-Cell Mediated Rejection (TCMR) from BK Virus Nephropathy (BKVN) Using Next Generation Sequencing (NGS) of the T-Cell Receptor (TCR)
G. Zeng, Y. Huang, P. Randhawa.
Pathology, University of Pittsburgh, Pittsburgh, PA.
Histopathology cannot determine whether T-cell infiltrates in renal allograft biopsies recognize donor HLA or BKV antigens. The ability of a T-cell to respond in an…
2015 American Transplant Congress
DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection
M. Willicombe,¹ M. Blow,² P. Brookes,² E. Santos,² D. Taube.¹
¹Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; ²H&I, Hammersmith Hospital, London, United Kingdom.
HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…
2015 American Transplant Congress
Delayed Graft Function in Patients Receiving Alemtuzumab Induction Therapy
M. Shindorf,¹ D. Fumo,¹ M. Weis,¹ W. Qu,¹ M. Rees,^1,2 J. Ortiz.¹
¹The University of Toledo Medical Center, Toledo, OH; ²The Alliance for Paired Donation, Maumee, OH.
Alemtuzumab (Campath 1-H) is a humanized monoclonal antibody directed at the CD52 glycoprotein that is becoming more prevalent as a choice for induction. Delayed graft…
2015 American Transplant Congress
Treatment of Hypertrophic Osteoarthropathy in an Intestinal Transplant Patient After Acute Cellular Rejection
M. Keck.
Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE.
Background:Hypertrophic osteoarthropathy involves abnormal proliferation of bone at distal extremities. It involves clubbing, periostitis of tubular bones and synovial effusions. Some causes of secondary hypertrophic…