2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…2015 American Transplant Congress
Prospects of Differentiating T-Cell Mediated Rejection (TCMR) from BK Virus Nephropathy (BKVN) Using Next Generation Sequencing (NGS) of the T-Cell Receptor (TCR)
Pathology, University of Pittsburgh, Pittsburgh, PA.
Histopathology cannot determine whether T-cell infiltrates in renal allograft biopsies recognize donor HLA or BKV antigens. The ability of a T-cell to respond in an…2015 American Transplant Congress
DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection
HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…2015 American Transplant Congress
Delayed Graft Function in Patients Receiving Alemtuzumab Induction Therapy
1The University of Toledo Medical Center, Toledo, OH; 2The Alliance for Paired Donation, Maumee, OH.
Alemtuzumab (Campath 1-H) is a humanized monoclonal antibody directed at the CD52 glycoprotein that is becoming more prevalent as a choice for induction. Delayed graft…2015 American Transplant Congress
Treatment of Hypertrophic Osteoarthropathy in an Intestinal Transplant Patient After Acute Cellular Rejection
Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE.
Background:Hypertrophic osteoarthropathy involves abnormal proliferation of bone at distal extremities. It involves clubbing, periostitis of tubular bones and synovial effusions. Some causes of secondary hypertrophic…2015 American Transplant Congress
Non-Inferiority of Graft Survival of Living Unrelated Kidney Transplant compared to Living Related Kidney Transplant as Analyzed by First Degree Relative
Henry Ford Transplant Institute, Detroit, MI.
The perceived advantage of donating a kidney directly to a family member is difficult to uncouple in the setting of voluntary exchange or other kidney…2015 American Transplant Congress
Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM
PurposeChronic active antibody mediated rejection (cAMR) and transplant glomerulopathy (TG) are major determinants of long-term allograft survival. However, the contribution of DSA and glomerular immunoglobulins…2015 American Transplant Congress
Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients
1Cleveland Clinic, Cleveland; 2School of Medicine, Leipzig University, Leipzig, Germany.
Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…2015 American Transplant Congress
An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation
The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…2015 American Transplant Congress
The Clinical Outcome of Plasma Cell-Rich Rejection of Kidney Allograft
Background: Plasma cell-rich rejection (PCRR) is a rare type of allograft rejection characterized by the presence of mature plasma cells. This type of rejection has…
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