Articles tagged "Rejection"

2015 American Transplant Congress
Eculizumab in the Treatment of Early Severe Acute Antibody Mediated Rejection Following HLA-Compatible Kidney Transplantation-Case Series
M. Singh,¹ N. Macias,² V. Tatapudi,¹ B. Lee.¹
¹Transplant Nephrology, UCSF Medical Center, San Francisco, CA; ²Nephrology, Hospital Gregorio Maranon, Madrid, Spain.
Severe early acute antibody-mediated rejection (AMR) is associated with poor allograft outcomes. Eculizumab is a humanized mouse monoclonal antibody against complement factor C5 that has…
2015 American Transplant Congress
Emerging Application of Active Immune Targeted Delivery in Transplantation
M. Uehara,¹ A. Jamil,¹ M. McGrath,¹ Z. Solhjou,¹ N. Banouni,¹ S. Tullius,² C. Jianjun,³ R. Abdi.¹
¹Renal Division, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical Shcool, Boston, MA; ²Division of Transplant Surgery, Brigham and Women's Hospital, Boston, MA; ³Materials Science and Engineering, University of Illinois at Urbana-Champaign, Champaingn, IL.
Targeted nanodelivery has created enormous excitement as a transformative approach to deliver therapeutics to tissues of interest. In recent years, we have made significant progress…
2015 American Transplant Congress
Eculizumab as a Rescue Therapy for Rhinovirus-Induced Antibody Mediated Rejection After Incompatible Kidney Transplantation
E. Tantisattamo, A. Shetty, B. Ho, L. Gallon, J. Friedewald.
Northwestern University, Chicago, IL.
Background: Despite being an effective strategy for overcoming ABO and HLA incompatibilities, desensitized kidney transplantation still has limitations. Early antibody mediated rejection (ABMR) may be…
2015 American Transplant Congress
Molecular Testing for Microcirculation Injury Enhances the Assessment of Antibody-Mediated Rejection in Human Cardiac Allograft Biopsies
B. Afzali,¹ E. Chapman,¹ B. Adam,¹ F. Riesgo Gil,² D. Kim,² L. Hidalgo,¹ P. Campbell,¹ B. Sis,¹ M. Mengel.¹
¹Dept. of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Div. of Cardiology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: Despite continuous attempts to refine diagnostic consensus, accurate assessment of Antibody-mediated rejection (AMR) is an ongoing unmet need. The microcirculation represents the primary target…
2015 American Transplant Congress
Patient Self-Reported Adherence to and Perceptions Towards Immunosuppressive Medications at the Outpatient Renal Transplant Clinic at St. Joseph's Healthcare Hamilton (SJHH)
K. Kak,¹ C. Burger,¹ D. Treleaven,² C. Wallace.¹
¹Pharmacy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; ²Medicine, McMaster University, Hamilton, ON, Canada.
Objectives To gain insight into the immunosuppressant adherence of patients followed by the Outpatient Renal Transplant Clinic at St. Joseph's Healthcare Hamilton (SJHH) and to…
2015 American Transplant Congress
OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)
F. Schena,¹ C. Curci,¹ F. Sallustio,¹ M. Trpevski,¹ G. De Palma,¹ M. Fiorentino,² M. Rossini,² M. Quaglia,³ E. Bozzola,³ S. Zanini,⁴ L. Furian,⁴ A. Toscano,⁵ E. Gallo,⁶ L. Gesualdo,² P. Stratta,³ P. Rigotti,⁴ F. Citterio,⁵ L. Biancone.⁶
¹C.A.R.S.O. Consortium, Valenzano, Italy; ²University of Bari, Bari, Italy; ³A.O.U. Maggiore della Carità, Novara, Italy; ⁴University of Padova, Padua, Italy; ⁵Cattolica Sacro Cuore University, Rome, Italy; ⁶University of Torino, Turine, Italy.
Introduction:TCMR is characterized by the reduction of vessel lumen with marked intimal thickening, fibrous hyperplasia and a strong component of leukocyte infiltrate. Aim of our…
2015 American Transplant Congress
Impact of Subclinical Rejection (SCR) and Acute Clinical (ACR) in Renal Transplant Recipients
R. Mehta, P. Sood, A. Cherukuri, S. Chen, G. Mour, C. Wu, N. Shah, C. Puttarajappa, P. Randhawa, A. Tevar, S. Hariharan.
University of Pittsburgh Medical Center, Pittsburgh, PA.
The importance of diagnosing subclinical rejection and its short and long term impact remains controversial.We prospectively evaluated 296 patients who had a kidney transplant at…
2015 American Transplant Congress
Noninvasive Diagnostic and Predictive Value in Renal Transplant Recipients by Measurement of Urine BCA-1
D. Chen, J. Chen, W. Peng.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Nephropathy, Zhejiang Province; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese.
ObjectiveTo investigate the relationship between early-stage renal acute rejection and the level of BCA-1 in urine, explore the diagnostic value and noninvasive monitoring in early…
2015 American Transplant Congress
Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival
F. Cosio,¹ C. Schinstock,¹ M. Stegall.²
¹Medicine, Mayo Clinic, Rochester, MN; ²Surgery, Mayo Clinic, Rochester, MN.
Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…
2015 American Transplant Congress
DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection
J. Wedel, S. Bruneau, K. Liu, N. Kochupurakkal, M. Laplante, D. Briscoe.
Transplant Research Program, Boston Children's Hospital, Boston, MA.
DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…