2016 American Transplant Congress
The Bacterial Enzyme IdeS, Inhibits HLA Antibody-Mediated NK Cell Activation and Cell Cytotoxicity (ADCC) In Vitro.
Background: Antibody-mediated rejection (ABMR) is a major obstacle for successful transplantation in HLA-sensitized patients. ADCC is one of the primary mechanisms for ABMR. IdeS cleaves…2016 American Transplant Congress
The Combined Effect of Acute Rejection and De Novo Donor-Specific Antibodies on Kidney Allograft Survival.
Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO.
While dnDSA is associated with graft loss in multiple studies, the clinical context in which dnDSA develops and contributes to graft loss is less well…2016 American Transplant Congress
Alloimmunity Through Non-HLA Epitopes in Kidney Transplantation.
Introduction: An unexpected diversity in the human genome has been identified including more than 2,500 nonsynonymous single nucleotide polymorphisms (nsSNP) and up to 20 homozygous…2016 American Transplant Congress
A Model to Explore the Potential Budget Impact of a Novel Screening Tool for the Detection of Subclinical Rejection Among Kidney Transplant Patients.
1Immucor, Inc, Waukesha, WI; 2Avalare Health, LLC, Washington, DC.
Background: Acute rejection among kidney transplant patients is common, with ~10% of individuals experiencing acute rejection within the first year and rising to 16-17% at…2016 American Transplant Congress
Pediatric Heart Transplantation Across a Positive Cross-Match Is Associated with High Rates of AMR but No Difference in Short Term Graft Loss, Dysfunction and Death (CTOTC-04 study).
Sensitization is common in pediatric heart transplant (HT) candidates. Waitlist mortality is high if a prospective -ve CDC-crossmatch (XM) is required, but HT across a…2016 American Transplant Congress
Characterization of Human Islet Transplant Specific Exosomes in a Xenoislet Transplantation Model.
Department of Surgery, University of Pennsylvania, Philadelphia, PA.
Background: There is a critical need for biomarker platforms for monitoring transplant rejection. We propose that transplant tissues release donor specific exosomes into recipient blood/…2016 American Transplant Congress
Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, The Houston Methodist, Houston, TX.
Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…2016 American Transplant Congress
C1-Inhibitor in Acute Antibody-Mediated Rejection Non-Responsive to Conventional Therapy in Kidney Transplant Recipients: A Pilot Study.
The use of complement inhibitors in the treatment of acute antibody-mediated rejection (AMR) has not been thoroughly evaluated. We performed a prospective, single-arm, pilot study…2016 American Transplant Congress
Antibody Mediated Rejection and Mixed Acute Rejection: Long Term Results and Predictive Factors for Graft Loss Following Proteasome Inhibitor Therapy.
1U of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati.
Purpose: Proteasome inhibitor (PI) therapy has been increasingly used to treated antibody mediated rejection (AMR) and mixed acute rejection (MAR). The purpose of this study…2016 American Transplant Congress
Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.
Hiroshima University, Hiroshima, Japan.
[Aim] Bacterial infections after ABO-incompatible transplantation are associated with refractory antibody (Ab)-mediated rejection (AMR). We demonstrated that bacterial pathogens provoke B cells, responding to human…
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