2016 American Transplant Congress
Benefit of Protocol Biopsies in Pediatric Kidney Transplant Patients.
Medical University of South Carolina, Charleston.
BackgroundMuch debate exists over the utility of protocol biopsies for pediatric kidney transplant recipients. While there is a growing amount of literature on the utility…2016 American Transplant Congress
First Clinical Experience with Belatacept in 3 Hand Transplanted Patients.
Study purposeBelatacept (CTLA4Ig) is an emerging treatment in solid organ transplantation. Effects on the development of donor specific antibodies (DSA) as well as its clinical…2016 American Transplant Congress
DEPTOR Inhibits mTORC1 in CD4+ T Cells and Increases Treg Function by Stabilizing Foxp3 Expression.
The modulation of PI-3K/Akt-induced signaling is critical for CD4+ Treg homeostasis and stability. Moreover, activation of PI-3K/Akt/mTOR signals within T cell subsets is associated with…2016 American Transplant Congress
The Impact of Ritonavir-Boosted Protease Inhibitors and Non-Depleting Antibody Induction on Outcomes in HIV-Infected Kidney Transplant Recipients.
Mount Sinai Hospital, New York.
Background: One-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. Protocols for immunosuppression…2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…2016 American Transplant Congress
Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.
Transplant Center, University of Chicago, Chicago, IL.
Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…2016 American Transplant Congress
Implications of Subclinical Borderline Acute Cellular Rejection Detected in Protocol Biopsies on Graft Outcomes.
Background: The effects of subclinical borderline acute cellular rejection (BACR-defined as I1T1 per Banff criteria) detected in protocol biopsies (Bx) on subsequent graft function and…2016 American Transplant Congress
Absence of Acute Allograft Rejection in the Early Post Operative Period in a Full Face VCA Recipient with a Positive B-Cell Flow Cytometric Crossmatch Utilizing an Induction Immunosuppression Regimen Including Anti-thymocyte and Anti-CD20 Agents.
Background: The presence of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) convey increased risk of allograft rejection. Patients suffering full-thickness burns to the face…2016 American Transplant Congress
Clinical Outcome in Pure T-Cell Mediated Acute Rejection of the Kidney with No Donor Specific Antibody or C4d Staining.
Background: T-cell mediated rejection (TCMR) is now considered to have little impact on renal graft function. This study re-evaluated the histologic phenotypes and clinical significance…2016 American Transplant Congress
Influence of Inclusion of the Liver on the Outcome After Intestinal Transplantation.
1Abdominal Transplantation, UZ Leuven, Leuven, Belgium; 2Pathology, UZ Leuven, Leuven, Belgium.
Introduction: Intestinal transplantation (ITx) is indicated when life-threatening complications occur following chronic total parenteral nutrition in intestinal failure patients. Several complications (TPN related irreversible liver…
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