Articles tagged "Rejection"

2016 American Transplant Congress
Impact of C3d and C1q-Binding DSA Detected Long-Term After Kidney Transplantation.
M. Crespo,^1,2 D. Redondo,^1,2 C. Garcia,³ J. Gimeno,⁴ M. Perez,^1,2 M. Mir,¹ J. Hernandez,³ J. Yelamos,² A. Faura,^1,2 J. Pascual.^1,2
¹Nephrology and Transplant, Hospital del Mar, Barcelona, Spain; ²Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain; ³Catalunya Reference Laboratory, Barcelona, Spain; ⁴Pathology, Hospital del Mar, Barcelona, Spain.
HLA DSA detected after kidney transplantation(KT) correlate with outcome, but not all are equal and produce the same functional consequences. Early complement-binding DSA were asssociated…
2016 American Transplant Congress
Increased Incidence of Clostridium difficile Infections with Proton Pump Inhibitor Use Post-Kidney Transplant.
M. Spinner,¹ K. Patel,¹ E. Neuner,¹ B. Stephany.²
¹Department of Pharmacy, Cleveland Clinic, Cleveland, OH; ²Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH.
Clostridium difficile infection (CDI) is often encountered in the solid-organ transplant patient population. The incidence in kidney transplant recipients ranges between 3.5-16%. There are CDI…
2016 American Transplant Congress
Tool to Assess Risk of Non-Adherence in Renal Transplant Candidates.
T. Kaiser,¹ K. Daley,² L. Dick,² L. Deye,² N. Parrish,² J. Huff,² A. Govil,¹ B. Abu Jawdeh,¹ G. Mogilishetty,¹ R. Alloway,¹ E. Woodle.¹
¹Medicine, University of Cincinnati, Cincinnati; ²Transplant, University of Cincinnati Medical Center, Cincinnati, OH.
Nonadherence (NA) is likely the primary driver of late graft loss and was found to occur in 59% of renal transplant (RTx) patients at our…
2016 American Transplant Congress
Designing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Longterm Heart Allograft Acceptance While Inducing Immune Cell Exhaustion, Treg Induction and Memory Cell Suppression.
E. Sula Karreci,¹ A. Mihali,¹ M. Uehara,¹ A. Kurdi,¹ L. Riella,¹ R. Abdi,¹ H. Fan,² P. Singh,² C. Nathan,² G. Lin,² J. Azzi.¹
¹Transplantation Research Center, Harvard Medical School, Boston, MA; ²Department of Microbiology and Immunology, Weill Cornell Medicine, New York City, NY.
The constitutive Proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. However, immunoproteasomes (IP or i-20S) are primarily expressed…
2016 American Transplant Congress
Mothers Are Often Sensitized and Sensitive: Antibody Mediated Rejection in Child to Mother Living Donor Liver Transplantation.
B. Movahedi,¹ N. Yu,² P. Martins,¹ A. Ahearn,¹ J. Stoff,¹ A. Bozorgzadeh.¹
¹Division of Organ Transplantation, UMass Memorial Medical Center, Worcester, MA; ²Clinical Pathology, Histocompatibility Laboratory, UMass Memorial Medical Center, Worcester, MA.
Background: Partial graft is especially more vulnerable to deleterious effects of donor specific HLA antibodies (DSA). Living liver donors and recipients are often family members.…
2016 American Transplant Congress
An Improved Method for the Evaluation of Microvascular Inflammation in Renal Allograft Biopsies.
M. Rooney,¹ Z. Ping,² D. Samarapungavan,³ R. Hennigar.⁴
¹Incyte Diagnostics, Spokane Valley, WA; ²Pathology, Beaumont Hospitals, Royal Oak, MI; ³Nephrology, Beaumont Hospitals, Royal Oak, MI; ⁴Nephropathology Associates, Little Rock, AR.
Background: Microvascular inflammation (MVI), assessed as glomerulitis (g) + peritubular capillaritis (ptc), is associated with T cell mediated (CMR) and antibody mediated (AMR) allograft rejection.…
2016 American Transplant Congress
A Non-Invasive Blood Transcriptional Assay, Ksort, Monitors Alloimmune Response in the Sailor Randomized Multicenter Trial.
J. Ekberg,¹ B. Jespersen,² K. Skov,² M. Sarwal,³ T. Sigdel,³ S. Hsieh,³ P. Lindner.¹
¹Transplantation, Sahlgrenska University Hospital, Gothenburg, Sweden; ²Nephrology, Skejby Hospital, Aarhus, Denmark; ³Surgery, University of California, San Francisco.
Non-invasive diagnosis and prediction of acute rejection (AR) is a critical unmet need. A In a randomized multicenter trial of 222 renal transplant recipients a…
2016 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
C. Yang,^1,4 L. Wang,³ R. Rong,^2,4 T. Zhu,^2,4 M. Xu.^2,4
¹Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; ²Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ³Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China; ⁴Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
2016 American Transplant Congress
Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.
H. Madariaga,¹ R. Ugarte,¹ C. Drachenberg,² N. Costa,¹ B. Thomas,¹ J. Bromberg,³ M. Weir,¹ A. Haririan.¹
¹Department of Medicine, University of Maryland Medical Center, Baltimore, MD; ²Department of Pathology, University of Maryland Medical Center, Baltimore, MD; ³Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
2016 American Transplant Congress
Acute Rejection: A Major Cause of Death-Censored Kidney Allograft Failure.
M. Alkadi,¹ J. Kim,¹ C. Hartono,² M. Aull,¹ T. Muthukumar.¹
¹Weill Medical College of Cornell University, New York; ²The Rogosin Institute, New York.
Introduction:The role of acute rejection as a cause of kidney allograft failure is not well defined in the current era of immunosuppression. We analyzed the…