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Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.

C. Yang,1,4 L. Wang,3 R. Rong,2,4 T. Zhu,2,4 M. Xu.2,4

1Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
2Urology, Zhongshan Hospital, Fudan University, Shanghai, China
3Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China
4Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.

Meeting: 2016 American Transplant Congress

Abstract number: A34

Keywords: Immunosuppression, Rejection

Session Information

Date: Saturday, June 11, 2016

Session Name: Poster Session A: B cells & AMR, Alloreactivity, Immune Regulation & Regulatory T Cells, T Cell Biology and Alloreactivity, Immunesuppression

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Halls C&D

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Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important regulatory innate cell population and have significant inhibitory effect on T cell-mediated responses. Here, we synthesized murine full length sFGL2 by eukaryotic expression system, and investigated the impact on differentiation and function of MDSCs. Bone marrow cells from BABL/c mice were cultured with or without 10 [mu]g/ml sFGL2 for 3 days and 5 days under 10 ng/ml GM-CSF stimulation. Compared with PBS, sFGL2 significantly induced CD11b+Ly6G–Ly6Chigh MDSC (MO-MDSC) differentiation but inhibited CD11b+Ly6G+Ly6Clow MDSC (PMN-MDSC) differentiation. The sFGL2-induced MO-MDSCs significantly inhibited T cells proliferation compared with those induced by PBS. Besides, sFGL2-induced MO-MDSCs demonstrated higher expression of arginase-1 and iNOS at both mRNA and protein level. Furthermore, adoptive transfer sFGL2-induced MO-MDSCs prolonged the skin allograft survival in mice. In the sFGL2-induced MO-MDSCs infusion group, the transplanted skin allograft showed mild inflammatory immune cell infiltration, less apoptosis and necrosis, and lower pro-inflammatory cytokines expression. T cells in the recipient mouse displayed a lower autoimmune phenotype (lower TCR+ CD44high CD62low cells). Taken together, our results indicate sFGL2 prompts MO-MDSCs differentiation and enhances their immunosuppressive function.[figure1]

CITATION INFORMATION: Yang C, Wang L, Rong R, Zhu T, Xu M. Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

Yang C, Wang L, Rong R, Zhu T, Xu M. Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/soluble-fibrinogen-like-protein-2-regulates-differentiation-and-enhances-immunosuppressive-function-of-myeloid-derived-suppressor-cells-in-allograft-immunity/. Accessed January 19, 2021.

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